A5114189440- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- vaccines and immunoinformatics approaches
- Kawasaki Disease and Coronary Complications
- Sarcoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- IgG4-Related and Inflammatory Diseases
- Cardiac tumors and thrombi
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Chromatin Remodeling and Cancer
- Surgical site infection prevention
- Adrenal and Paraganglionic Tumors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer Research and Treatments
- BRCA gene mutations in cancer
Sree Chitra Thirunal Institute for Medical Sciences and Technology
2024-2025
Safdarjang Hospital
2024
Manchester Royal Infirmary
2018
Broad Institute
2018
Dana-Farber Cancer Institute
2018
Massachusetts Institute of Technology
2018
Gene Therapy Laboratory
2009
Karolinska University Hospital
2003-2008
Karolinska Institutet
2004-2007
Glanrhyd Hospital
2002
Breast cancer is globally the most common malignancy in women. Her2-targeted monoclonal antibodies are established treatment modalities, and vaccines late-stage clinical testing patients with breast known to promote tumour-killing through mechanisms like antibody-dependent cellular cytotoxicity. It therefore increasingly important study immunological consequences of conventional strategies. In this study, functional tests four-colour flow cytometry were used detect natural killer (NK)-cell...
Abstract Background Takayasu Arteritis (TA), a type of large vessel vasculitis involving the aorta and its major branches, is highly prevalent in Southeast Asian countries. Although cardiac involvement rare, it most common cause mortality TA. Case Summary Here, we present case 35-year-old woman, with no known previous co-morbidities, who presented sudden onset acute chest pain dyspnea. 12 lead ECG revealed ST-elevation positive troponin, leading to clinical diagnosis ST Elevation Myocardial...
B-cell chronic lymphocytic leukaemia (B-CLL) is characterised by the progressive accumulation of monoclonal CD5(+) B cells. In a previous study, we have analysed expression profile apoptosis-regulating genes using cDNA-based microarray and found overexpression antiapoptotic bcl-2 family member, bfl-1, in B-CLL cells with an apoptosis-resistant phenotype. this bfl-1 mRNA levels been determined competitive PCR extended population patients to characterise its role disease progression...
Breakdown of immune self tolerance is speculated to cause autoimmune diseases, but most studies on use foreign molecules as targets. In this study, we show another approach using delivery a maleylated protein macrophage-specific scavenger receptors. Mice generate Abs against the form ubiquitous Ag, mouse serum albumin (MSA), although native MSA nonimmunogenic. This generation anti-maleyl depends binding maleyl receptors in vivo, since coinjection serologically unrelated receptor ligand...
Abstract We previously demonstrated that dendritic cells (DC) have endocytosed apoptotic bodies of autologous leukemic (Apo‐DC) can boost antileukemic T‐cell responses. In this study, we report a description the production procedure and product specification Apo‐DC vaccine preparations for clinical use. Enriched populations CD14+ monocytic precursors CD19+ leukaemic were obtained using CliniMACS technology from single leukapheresis product. Apoptotic by irradiating (5 Gy) selected B cells....
Abstract Immunoglobulin G4-related disease (IgG4 RD), first described in 2001, as a case of autoimmune pancreatitis, is multisystemic condition, involving the salivary glands, bile ducts, pancreas, retroperitoneal organs, and mesentery associated with raised level serum IgG4. Reports coronary involvement by IgG4 RD are scarce we could find only 16 reports literature. Here, present 61-year-old lady, no known comorbidities, who presented rapid progression artery stenosis. Initially, she mild...
Abstract A cardiac hemangioma is a rare primary benign intracardiac tumor characterized by proliferation of endothelial cells. The lesions are hyperintense on T2/short tau inversion recovery magnetic resonance imaging (MRI) and show avid enhancement retention contrast agents. Here we present case histopathologically proven showing uptake Dodecanetetraacetic acid - octreotate (DOTATATE), masquerading as paraganglioma in MRI positron emission tomography imaging.
A BSTRACT Wilms tumor (WT) is a relatively common pediatric tumor. Depending on the stage of disease, treatment includes surgery, chemotherapy, and radiotherapy. Chemotherapy radiotherapy can induce differentiation cells to rhabdoid morphology that masquerade as kidney. We report rare case WT with subsequent neoadjuvant chemotherapy. Rhabdoid kidney was initially considered sarcomatous variant WT, however later classified separately due distinct behavior. This makes it challenging...
Abstract Introduction: Triple-negative breast cancer (TNBC) is a poor prognosis subset characterized by relatively few mutations but extensive copy number alterations (CNAs). Cell-free DNA (cfDNA) offers the potential to overcome infrequent tumor biopsies in metastatic TNBC (mTNBC) and interrogate genomics of chemotherapy resistance. Methods: 506 archival or fresh plasma samples were identified from 164 patients with mTNBC who had previously received chemotherapy. We performed low coverage...