A5078467145- Air Quality and Health Impacts
- Occupational and environmental lung diseases
- Carcinogens and Genotoxicity Assessment
- Occupational exposure and asthma
- Climate Change and Health Impacts
- Health, Environment, Cognitive Aging
- Heavy Metal Exposure and Toxicity
- Renal and related cancers
- Energy and Environment Impacts
- Acute Lymphoblastic Leukemia research
- Noise Effects and Management
- Childhood Cancer Survivors' Quality of Life
- Inflammatory Bowel Disease
- Inhalation and Respiratory Drug Delivery
- Pesticide Exposure and Toxicity
- Chromium effects and bioremediation
- Toxic Organic Pollutants Impact
- Urological Disorders and Treatments
- Testicular diseases and treatments
- Human Health and Disease
- Air Quality Monitoring and Forecasting
- Environmental Justice and Health Disparities
- Indoor Air Quality and Microbial Exposure
- Rheumatoid Arthritis Research and Therapies
- Pediatric health and respiratory diseases
Karolinska Institutet
2015-2024
Stockholm County Council
2006-2024
Centre for Palaeogenetics
2016-2024
Regionshospitalet Viborg
2021
Creative Commons
2020
Örebro University
2020
Örebro University Hospital
2020
Utrecht University
2015
Institute of Social and Preventive Medicine
2015
University of Bern
2015
Ambient particles are believed to be a specific health hazard, although the underlying mechanisms not fully understood. There data in literature indicating fast and substantial systemic uptake of from lung. The present authors have developed an improved method produce ultrafine with more stable radiolabelling defined particle size range. Fifteen subjects inhaled technetium 99m ( Tc)-labelled carbonaceous 100 nm size. Radioactivity over lung was followed for 70 h. clearance these lungs...
Human pulmonary retention of 35 nm 99mTc-labeled carbonaceous particles, produced with a modified Technegas generator, was followed for 24 h using gamma camera imaging technique. Nine healthy subjects and four asthmatics inhaled the test particles. Particle labeling stability tested in vitro during 48 h. We also measured vivo leaching blood urine One additional subject exposed to particles unstable labeling. There were no significant differences between asthmatic any parameters studied....
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disorder. Next to tobacco smoking, occupational exposure the most important risk factor for COPD in high-income countries. To enable preventative measures, more knowledge needed on which specific exposures that are related of developing men and women.A population-based cohort was formed from subjects responding Stockholm Public Health Surveys 2002, 2006, 2010, followed up until 2014. The dataset linked quantitative job...
To assess the effects of occupational inhalable exposures on rheumatoid arthritis (RA) development and their interactions with smoking RA-risk genes, stratifying by presence anticitrullinated protein antibodies (ACPA).Data came from Swedish Epidemiological Investigation RA, consisting 4033 incident RA cases 6485 matched controls. Occupational histories were retrieved, combining a national job-exposure matrix, to estimate exposure 32 agents. Genetic data used define Risk Score (GRS) or...
Abstract Objective Within the scope of Exposome Project for Health and Occupational Research on applying exposome concept to working life health, we aimed provide a broad overview status knowledge occupational exposures associated health effects across multiple noncommunicable diseases (NCDs) help inform research priorities. Methods We conducted narrative review risk factors that can be considered have “consistent evidence an association,” or where there is “limited/inadequate association” 6...
To examine the associations of specific occupations and occupational exposures with risk amyotrophic lateral sclerosis (ALS) in Swedish population.A nested case-control study was conducted Sweden. Patients ALS diagnosed during 1991-2010 (n=5020) were identified from National Patient Register 5 controls per case (n=25 100) randomly selected general population, individually matched to cases by birth year sex. Occupational history obtained censuses 1970, 1980 1990. The Nordic Cancer Study Job...
Objective Environmental factors are of importance for the etiology rheumatoid arthritis ( RA ), but much remains unknown concerning contributions from distinct occupational hazards. We explored association between occupation and risk anti–citrullinated protein antibody ACPA )+ or − . Methods analyzed 3,522 cases 5,580 controls Swedish population–based Epidemiological Investigation Rheumatoid Arthritis case–control study. A questionnaire was used to obtain information on work history...
Objective Airborne agents including cigarette smoke associate with an increased risk of rheumatoid arthritis (RA). We analysed to which extent occupational exposure asbestos and silica confers developing serologically defined subsets RA. Methods This Swedish population-based case-control study enrolled incident RA cases between 1996 2013 (n=11 285), identified through national public authority quality registers, as well from the Epidemiological Investigation Rheumatoid Arthritis (EIRA)...
Objective To determine whether occupational exposure to silica dust is associated with an increased risk of developing sarcoidosis. Design Case–control study all individuals between 20 and 65 years age diagnosed sarcoidosis (D86) in Sweden 2007 2016. Controls were matched cases (2:1) based on age, sex county at the time diagnosis. A Job Exposure Matrix was used estimate controls. Setting Medical data from National Outpatient Register implement a case–control analysis, while two controls for...
<h3>Background</h3> Ambient particulate air pollution has been linked to cardiovascular disease. Occupational particle exposure levels may be several times higher than ambient but less studied. <h3>Objectives</h3> The authors investigated the association between occupational particles and incidence of ischaemic heart disease (IHD). <h3>Methods</h3> cohort included all manual workers in Swedish national census 1980 with information on demographic data occupation. Information hospital...
Abstract Background: Data are scarce on the association between prenatal/preconception environmental exposure and testicular germ cell tumor (TGCT) in offspring. We examined parental occupational exposures to heavy metals welding fumes relation TGCT offspring a registry-based case–control study (NORD-TEST Study). Methods: identified cases diagnosed at ages 14–49 years Finland (1988–2012), Norway (1978–2010), Sweden (1979–2011) through nationwide cancer registries. These were individually...
Background: Testicular germ cell tumors (TGCT) were suggested to have a prenatal environmentally related origin. The potential endocrine disrupting properties of certain solvents may interfere with the male genital development in utero. Objectives: We aimed assess association between maternal and paternal occupational exposures organic during period TGCT risk their offspring. Methods: This registry-based case control study included cases aged 14–49 y (n=8,112) diagnosed from 1978 2012...
Amyotrophic lateral sclerosis (ALS) has been consistently related to "electric occupations," but associations with magnetic field levels were generally weaker than those electrical occupations. Exposure electric shock suggested as a possible explanation. Furthermore, studies based on mortality or prevalence of ALS, and often had limited statistical power.Using two three job-exposure matrices, we evaluated the relationship occupational fields, shocks, occupations, incident ALS in large...
<h3>Objectives</h3> A potential impact of exposure to endocrine disruptors, including pesticides, during intrauterine life, has been hypothesised in testicular germ cell tumour (TGCT) aetiology, but assessment is challenging. This large-scale registry-based case–control study aimed investigate the association between parental occupational pesticides and TGCT risk their sons. <h3>Methods</h3> Cases born 1960 or onwards, aged 14 49 years, diagnosed 1978 2013 Denmark, Finland, Norway Sweden,...
Hexavalent chromium (Cr(VI)) is classified as a human carcinogen. Occupational Cr(VI) exposure can occur during different work processes, but the current to at Swedish workplaces unknown. This cross-sectional study (SafeChrom) recruited non-smoking men and women from 14 companies with potential (n = 113) controls 6 without 72). Inhalable was measured by personal air sampling (outside of respiratory protection) in exposed workers. Total Cr urine (pre- post-shift, density-adjusted) red blood...
Objectives: To examine the influence of an airway diagnosis in adolescence on future health and occupation Swedish men. Methods: Data were collected from linkage four national registers: Military Service Conscription Register, Population Housing Censuses, Inpatient Care Register National Cause Death Register. A job-exposure matrix for airway-irritating substances was developed application conscription cohort. The cohort included 49 321 men born 1949–51. Three groups—(1) healthy, (2)...
Abstract Purpose The aim of this study was to examine if exposures chemicals at the workplace were associated with an increased risk postmenopausal breast cancer, using improved exposure estimates. Methods design is a case–control study, nested within cohort women from Malmö Diet and Cancer Study. comprised 2400 women, 731 cases 1669 matched controls, born 1923–1950 living in Malmö, Sweden between 1991 1996. An occupational hygienist reclassified probability for given by job-exposure matrix,...
Objectives The aim of this study was to investigate if occupational exposure inorganic particles or welding fumes during pregnancy is associated with negative birth outcomes. Design A prospective national cohort study. Setting All single births from 1994 2012 in Sweden. Information on weight, preterm birth, small for gestational age, smoking habits, nationality, occupation, absence work and education obtained nationwide registers. Exposure (mg/m 3 ) assessed a job matrix. Participants This...
Objectives The aim of this study was to investigate if exposure chemicals in the workplace associated with an increased risk postmenopausal breast cancer. Methods comprised women born 1923–1950 living Malmö city, Sweden, 1991–1996, and enrolled for a prospective population cohort study. Occupational various assessed from job-exposure matrices. An extensive set individual data on hormonal cancer factors were collected via baseline questionnaire used confounding control. First time diagnoses...
Objectives We estimated the association between occupational exposures to five different organic dusts: wood, animal, paper, textile and flour dust risk of developing rheumatoid arthritis (RA). Methods This population-based case–control study analysed 12 582 incident cases 129 335 controls. Participants were identified from national public authority quality registers. Census data on occupations collected 1960–2010 we exposure with help job-exposure matrices. used logistic regression assess...
Some largely inconsistent associations between parental occupational dust exposure and childhood cancer have been reported, with maternal exposures inadequately studied. The authors examined whether or paternal to animal, wood, textile, paper around a child's birth was associated an increased risk of cancer, both overall by type (leukemias, lymphomas, central nervous system tumors, other cancers).
Maternal and paternal occupational exposure to pesticides was linked leukemia in the offspring some previous studies. Risks for other cancers, particularly from maternal exposure, are largely unknown. We examined association between childhood cancer a Swedish register-based case-control study (1960-2015). Cancer cases <20 years old were identified Register (n = 17313) matched controls (1:25) on birth year sex. Employment history of each biological parent around child's retrieved six censuses...
Background: It remains unclear whether parental occupational exposure to hydrocarbon solvents (HCS) or engine exhaust fumes (EEF) is associated with higher risks of cancer in the offspring. Objectives: Our aim was estimate relative childhood cancers maternal paternal aliphatic/alicyclic, aromatic, chlorinated HCS gasoline/diesel EEF. Methods: We conducted a case–control study which individuals <20y old, born 1960–2014, were identified from Swedish National Cancer Register (1960–2015) at...