A5024484324- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune and Inflammatory Disorders Research
- Immunodeficiency and Autoimmune Disorders
- Complement system in diseases
- Genetic Associations and Epidemiology
- Cytokine Signaling Pathways and Interactions
- Biosimilars and Bioanalytical Methods
- HER2/EGFR in Cancer Research
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Thyroid Disorders and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hepatitis C virus research
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Toxin Mechanisms and Immunotoxins
- Cell Adhesion Molecules Research
- Peripheral Neuropathies and Disorders
- Urticaria and Related Conditions
- Acute Lymphoblastic Leukemia research
- Spondyloarthritis Studies and Treatments
Karolinska Institutet
2016-2025
deCODE Genetics (Iceland)
2020-2025
University of Iceland
2004-2025
National University Hospital of Iceland
2004-2025
Reykjavík University
2004-2024
Amgen (Germany)
2024
RMIT University
2023
Centre Hospitalier Universitaire de Rouen
2023
Hôpital Purpan
2023
Harbor–UCLA Medical Center
2023
High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge gap between genome diseases. Here we performed association studies Olink Explore 3072 data generated by UK Biobank Pharma Proteomics Project
To determine whether cigarette smoking influences the response to treatment in patients with early rheumatoid arthritis (RA).We retrieved clinical information about entering Epidemiological Investigation of Rheumatoid Arthritis (EIRA) RA cohort from 1996 2006 (n=1,998) who were also Swedish Rheumatology Register (until 2007). Overall, 1,430 1,621 registered followed up time inclusion EIRA cohort. Of these, 873 started methotrexate (MTX) monotherapy at inclusion, and 535 later a tumor...
Previous studies have shown associations between low mannose-binding lectin (MBL) level or variant MBL2 genotype and sepsis susceptibility. However, MBL deficiency has not been rigorously defined, with outcomes subjected to multivariable analysis.We reanalyzed results in a large cohort use of individual data from 4 involving total 1642 healthy control subjects systematically defined reliable cutoff. Subsequently, were reassessed extend previous associations, adjustment for known outcome...
Objective To identify predictors of response to methotrexate (MTX) in early rheumatoid arthritis (RA). Methods In the SWEFOT trial, patients with RA symptom duration <1 year started MTX monotherapy (20 mg/weekly) and 405/487 continued until 3–4- month visit. The primary outcome measure was DAS28-based European League against Rheumatism (EULAR) criteria. Multivariate logistic regression used study association between following baseline characteristics: gender, age, duration, cigarette...
To investigate whether overweight/obesity at diagnosis affects the chances of decrease in disease activity and pain early rheumatoid arthritis (RA).We investigated incident RA cases from population-based Epidemiological Investigation risk factors for Rheumatoid Arthritis (EIRA) study (2006-2009, N=495) with clinical follow-up Swedish Rheumatology Quality Register. At diagnosis, 93% received disease-modifying antirheumatic drugs (DMARDs) (86% methotrexate). The odds achieving a good response...
Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS) are strongly associated with autoimmune diseases in animal models. The human NCF1 gene is very complex both functional and non-functional copies genotyping requires assays specific for genes. We aimed at investigating association function the missense single nucleotide polymorphism (SNP), rs201802880 (here denoted NCF1-339) systemic lupus erythematosus (SLE).We genotyped NCF1-339 SNP 973 Swedish patients SLE 1301...
Objectives Prediction of radiographic progression (RP) in early rheumatoid arthritis (eRA) would be very useful for optimal choice among available therapies. We evaluated a multi-biomarker disease activity (MBDA) score, based on 12 serum biomarkers as baseline predictor 1-year RP eRA. Methods Baseline score erythrocyte sedimentation rate (DAS28-ESR), C-reactive protein (DAS28-CRP), CRP, MBDA scores and DAS28-ESR at 3 months were analysed 235 patients with eRA from the Swedish Farmacotherapy...
To investigate the frequency of remaining pain in early rheumatoid arthritis (RA) after 3 months treatment with methotrexate as only disease modifying antirheumatic drug, a special focus on patients good clinical response.The study base was cases reported to population-based RA cohort who had followup data from Swedish Rheumatology Quality Register (n = 1,241). The Disease Activity Score 28 joints European League Against Rheumatism (EULAR) response criteria were used evaluate good, moderate,...
This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation oral microbiota, systemic and inflammatory mediators, RA disease activity. Forty underwent full-mouth dental/periodontal rheumatological examination, including collection blood, saliva, gingival crevicular fluid (GCF) subgingival plaque. Composition plaque saliva microbiota were analysed using 16S rRNA sequencing levels mediators by multiplex-immunoassay. The majority...
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) ~1 million controls from Northwestern Europe. searched outside the HLA-locus through effect on coding, mRNA expression in several tissues levels plasma proteins (SomaScan) did network analysis (Qiagen). Results found 25 sequence variants overall, 33 2 RA, altogether...
Abstract Gene promoter and enhancer sequences are bound by transcription factors depleted of methylated CpG sites (cytosines preceding guanines in DNA). The absence CpGs these typically correlates with increased gene expression, indicating a regulatory role for methylation. We used nanopore sequencing to determine haplotype-specific methylation rates 15.3 million units 7,179 whole-blood genomes. identified 189,178 where three or more proximal were unmethylated on at least one haplotype. A...
Anti-tumor necrosis factor alpha (anti-TNF) therapy is a mainstay of treatment in rheumatoid arthritis (RA). The aim the present study was to test established RA genetic risk factors determine whether same alleles also influence response anti-TNF therapy.A total 1,283 patients receiving etanercept, infliximab, or adalimumab were studied from among an international collaborative consortium 9 different cohorts. primary end point compared with good according European League Against Rheumatism...
<h3>Background</h3> Treatment strategies blocking tumour necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA). However, a significant subset of does not respond for unknown reasons. Currently, there are no means identifying these before treatment. This study was aimed at genetic factors predicting anti-TNF treatment outcome RA using genome-wide association approach. <h3>Methods</h3> We conducted multistage, primary analysis 2 557 253...
<h3>Objective</h3> To investigate the 2-year clinical and radiological outcomes of patients with early rheumatoid arthritis (RA; symptom duration <1 year) who had initially responded well to methotrexate monotherapy. <h3>Methods</h3> In SWEFOT trial, all 487 started (target dose 20 mg/week). After 3–4 months, 147 low disease activity, 28-joint based activity score (DAS28) ≤3.2. These were not randomly selected but followed in regular care for 2 years. Clinical radiographic progression...
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment the utility SNP data for predicting efficacy RA patients was performed context a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled comparative evaluation predictions developed by...
<h3>Objectives</h3> To study clinical predictors for radiographic progression after 1 year in an early rheumatoid arthritis (RA) trial. <h3>Methods</h3> In the SWEFOT trial population, disease modifying antirheumatic drug (DMARD) naïve RA patients started methotrexate; 3-month responders (DAS28 <3.2) continued (n=147), while non-responders were randomised to addition of sulfasalazine+hydroxychloroquine (n=130) or infliximab (n=128). X-rays scored by Sharp-van der Hejde score (SHS) method...
The aim of this paper was to analyse the impact obesity, in addition known predictors, on disease outcome early rheumatoid arthritis (RA).Body mass index (BMI) available 260 patients from Swedish pharmacotherapy trial (SWEFOT). Differences activity (DAS28), functional impairment (HAQ), pain (Visual Analogue Scale, VAS-pain) and radiographic damage were evaluated over 24 months between BMI categories (obese >30, n=43; overweight BMI=25-29.9, n=74; normal <25, n=143) using non-parametric...
Abstract Background Rheumatoid arthritis (RA) is classified as seropositive or seronegative, depending on the presence/absence of rheumatoid factor (RF), primarily IgM RF, and/or anti-citrullinated protein antibodies (ACPA), commonly detected using anti-cyclic citrullinated peptide (CCP) assays. Known risk factors associate with more severe form RA; less known about seronegative RA. Here, we examine and clinical phenotypes in relation to presence autoantibodies RA subset that traditionally...
Objective Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers OA that could predict disease occurrence and/or joint replacement. Methods Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, whom 12,178 individuals had 2,524 undergone We performed a case–control identification potential protein hip, knee, hand OA, prospective Results Among large panel assessed, cartilage...