A5075828513- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Mobile Health and mHealth Applications
- Asthma and respiratory diseases
- Digital Mental Health Interventions
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Drug-Induced Adverse Reactions
- Blood Pressure and Hypertension Studies
- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Health and Risk Factors
- Pharmaceutical industry and healthcare
- Lipoproteins and Cardiovascular Health
- Sleep and related disorders
- Genetic and phenotypic traits in livestock
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Health Systems, Economic Evaluations, Quality of Life
- RNA Research and Splicing
- Nutritional Studies and Diet
- Gene expression and cancer classification
- Psoriasis: Treatment and Pathogenesis
- Autism Spectrum Disorder Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
Scripps Research Institute
2016-2025
Scripps Institution of Oceanography
2013-2025
Scripps (United States)
2013-2023
University of Florida
2022
Scripps Clinic
2021
Scripps Health
2012-2018
J. Craig Venter Institute
2016
Creative Commons
2016
Janssen Scientific Affairs (United States)
2016
Institute of Dermatology
2016
BackgroundAcute infections can cause an individual to have elevated resting heart rate (RHR) and change their routine daily activities due the physiological response inflammatory insult. Consequently, we aimed evaluate if population trends of seasonal respiratory infections, such as influenza, could be identified through wearable sensors that collect RHR sleep data.MethodsWe obtained de-identified sensor data from 200 000 individuals who used a Fitbit device March 1, 2016, 2018, in USA. We...
Active engagement in the management of hypertension is important improving self-management behaviors and clinical outcomes. Mobile phone technology using wireless monitoring tools are now widely available to help individuals monitor their blood pressure, but little known about conditions under which such can effect positive behavior changes or outcomes.To study influence self-monitoring program patient activation measures on health behaviors, medication adherence, pressure levels as well...
<h3>Background</h3> There are few empirical data to inform the debate surrounding use and regulation of direct-to-consumer (DTC) genome-wide disease risk tests. This study aimed determine long term psychological, behavioural, clinical impacts genomic testing for common disease. <h3>Methods</h3> The Scripps Genomic Health Initiative is a prospective longitudinal cohort adults who purchased Navigenics Compass, commercially available test. Web based assessments were administered at baseline,...
Background. Mobile health and digital medicine technologies are becoming increasingly used by individuals with common, chronic diseases to monitor their health. Numerous devices, sensors, apps available patients consumers–some of which have been shown lead improved management outcomes. However, no randomized controlled trials conducted examine care costs, most failed provide study participants a truly comprehensive monitoring system. Methods. We prospective trial adults who had submitted...
<h3>Importance</h3> High and continually increasing pharmaceutical drug spending is a major health policy concern in the United States. <h3>Objective</h3> To demonstrate trends prices among popular brand-name prescription drugs. <h3>Design, Setting, Participants</h3> This economic evaluation of focuses on 49 top-selling medications Pharmacy claims data from January 1, 2012, through December 31, 2017, were obtained Blue Cross Shield Axis, database that includes more than 35 million...
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment the utility SNP data for predicting efficacy RA patients was performed context a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled comparative evaluation predictions developed by...
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare common genetic environmental determinants. To identify variants associated AN, we pursued a series of sequencing genotyping studies focusing on the coding regions upstream sequence 152 candidate genes in total 1205 AN cases 1948 controls. We identified individual variant associations Estrogen Receptor-ß (ESR2) gene, as well set Epoxide Hydrolase 2 (EPHX2) an initial...
To analyze the methylome of normal and osteoarthritic (OA) knee articular cartilage to determine role DNA methylation in regulation gene expression vitro.DNA was isolated from human (n = 11) OA 12) analyzed using Infinium HumanMethylation450 BeadChip array. integrate transcription, RNA sequencing performed on validated by quantitative polymerase chain reaction. Functional validation TC28 cell line primary chondrocytes that were treated with inhibitor 5-aza-2'-deoxycytidine (5-aza-dC).DNA...
We developed a smartphone application, MyGeneRank, to conduct prospective observational cohort study (NCT03277365) involving the automated generation, communication, and electronic capture of response polygenic risk score (PRS) for coronary artery disease (CAD). Adults with an existing 23andMe genetic profiling self-referred study. evaluated self-reported actions taken in personal CAD PRS information, special interest initiation lipid-lowering therapy. 19% (721/3,800) participants provided...
A number of benefits have been described for the long-term practice meditation, yet little is known regarding immediate neurological and cardiovascular responses to meditation. Wireless sensor technology allows, first time, multi-parameter quantitative monitoring an individual's during The present study examined inter-individual variations meditation through continuous EEG, blood pressure, heart rate its variability (HRV) in novice experienced meditators.Participants were 20 meditators...
Background: As a result of the digital revolution coming to medicine, number new tools are becoming available and starting be introduced in clinical practice. Objective: We aim assess health care professional consumer attitudes toward medical technology including smartphones, genetic testing, privacy, patient-accessible electronic records. Methods: performed survey with 1406 providers 1102 responders. Results: Consumers who completed were more likely prefer technologies for diagnosis...
Clinical response to the atypical antipsychotic paliperidone is known vary among schizophrenic patients. We carried out a genome-wide association study identify common genetic variants predictive of efficacy.We leveraged collection 1390 samples from individuals European ancestry enrolled in 12 clinical studies investigating efficacy extended-release tablet ER (n1=490) and once-monthly injection palmitate (n2=550 n3=350). using general linear model (GLM) analysis on three separate cohorts,...
Polygenic risk scores (PRSs) are a summarization of an individual's genetic for disease or trait. These being generated in research and commercial settings to study how they may be used guide healthcare decisions. PRSs should updated as knowledgebases improve; however, no guidelines exist their generation updating.
African Americans have been understudied in genome wide association studies of diabetes and related traits. In the current study, we examined joint single nucleotide polymorphisms (SNPs) copy number variants (CNVs) with fasting insulin an index resistance (HOMA-IR) HyperGEN a family based study proband ascertainment for hypertension. This analysis is restricted to 1,040 without diabetes. We generated allele specific CNV genotypes at 872,243 autosomal loci using Birdsuite, freely available...
Background: The advent of digital technology has enabled individuals to track meaningful biometric data about themselves. This novel capability spurred nontraditional health care organizations develop systems that aid users in managing their health. One the most prolific is Walgreens Balance Rewards for healthy choices (BRhc) program, an incentivized, Web-based self-monitoring program. Objective: study was performed evaluate self-tracking characteristics enrolled Walgreens' BRhc including...
The All of Us (AoU) Research Program provides a comprehensive genomic dataset to accelerate health research and medical breakthroughs. Despite its potential, researchers face significant challenges, including high costs inefficiencies associated with data extraction analysis. AoUPRS addresses these challenges by offering versatile cost-effective tool for calculating polygenic risk scores (PRS), enabling both experienced novice leverage the AoU discoveries.