A5062527804- Diabetes, Cardiovascular Risks, and Lipoproteins
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Lipoproteins and Cardiovascular Health
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Proteoglycans and glycosaminoglycans research
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Circadian rhythm and melatonin
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Blood Pressure and Hypertension Studies
- Regulation of Appetite and Obesity
- Cardiovascular Function and Risk Factors
- Cholesterol and Lipid Metabolism
- Nutritional Studies and Diet
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Cellular Mechanics and Interactions
- Biochemical Analysis and Sensing Techniques
Scripps Research Institute
2013-2024
Molecular Medicine Research Institute
2018
Scripps Institution of Oceanography
2017
Tulane University
2004-2013
Louisiana State University
1985-2009
University Medical Center New Orleans
1988-2009
University Medical Center
1993-2009
University Hospital and Clinics
2009
University of California, San Francisco
1993-2008
Gladstone Institutes
2003-2007
BACKGROUND. Recent studies have shown considerable variation in body fatness among children and adolescents defined as obese by a percentile rank for skinfold thickness. METHODS. We examined the relationship between percent fat risk elevated blood pressure, serum total cholesterol, lipoprotein ratios biracial sample of 3320 aged 5 to 18 years. Equations developed specifically using sum subscapular (S) triceps (T) skinfolds were used estimate fat. The S/T ratio provided an index trunkal...
Neutrophils exposed to chemoattractants polarize and accumulate polymerized actin at the leading edge. In neutrophil-like HL-60 cells, this asymmetry depends on a positive feedback loop in which accumulation of membrane lipid, phosphatidylinositol (PI) 3,4,5-trisphosphate (PI[3,4,5]P3), leads activation Rac and/or Cdc42, vice versa. We now report that Cdc42 play distinct roles regulating asymmetry. absence chemoattractant, expression constitutively active stimulates plasma polymers...
Leukocyte telomere length (LTL) is ostensibly a biomarker of human aging. Cross-sectional analyses have found that LTL relatively short in host aging-related diseases. These studies also provided indirect estimates age-dependent shortening. In this paper, the authors report findings first comprehensive longitudinal study 450 whites and 185 African Americans Louisiana (aged 31.4 37.4 years at baseline (1995–1996) follow-up (2001–2006) examinations, respectively) participating Bogalusa Heart...
Recently, independent factors representing different features of insulin resistance syndrome (Syndrome X) have been identified by factor analysis in middle-aged and elderly adult populations. In this study, was applied to the clustering characteristics Syndrome X a biracial (Black-White) community-based population 4,522 children (ages 5-11 years), adolescents 12-17 young adults 18-38 years) from Bogalusa Heart Study who were screened during 1988-1996. Ponderal index (weight (kg)/height...
Serum lipoprotein profiles in 3182 children, ages 5-14 years, were studied a biracial community as part of the Bogalusa Heart Study to describe early natural history atherosclerosis. White and black children showed similar mean levels beta-lipoproteins. Pre-beta-lipoprotein levels, however, significantly higher white shildren, while alpha-lipoprotein found children. Girls had generally beta- pre-beta-lipoprotein lower than boys, although differences not significant at each age group. With...
Serum lipid profiles of 3,446 (91% population) children, ages 5-14 years, were determined in a biracial community (Bogalusa, Louisiana) as part program investigating the early natural history atherosclerosis. Black children had significantly higher mean levels serum cholesterol than white (170 mg/dl vs 162 mg/dl, P less 0.0001). On other hand, lower triglycerides found blacks whites (61 73 Girls boys both races (blacks, 64 59 0.001; whites, 77 69 0.001). The racial differences and...
BACKGROUND The value of lipoprotein (a) [Lp(a)] in the prediction coronary artery disease risk very early life remains to be established different racial groups. METHODS AND RESULTS Serum Lp(a) distribution and its relation parental histories myocardial infarction were examined 2,438 children (8-17 years old) from a biracial community. Parental was used as surrogate measure future offspring. levels averaged 1.7-fold higher blacks than whites (p less 0.0001). A small but significant sex...
The melanocortin-4 receptor (MC4R), a centrally expressed G protein–coupled (GPCR), is essential for the maintenance of long-term energy balance in humans. Mutations MC4R are most common genetic cause obesity. Since activation this leads to decrease food intake, also major therapeutic target treatment Control activity vivo modulated by opposing effects anorexigenic agonist α–melanocyte-stimulating hormone (α-MSH) and orexigenic antagonist agouti-related protein (AGRP). In addition,...
This is a consortium of large children's cohorts that contain measurements major cardiovascular disease (CVD) risk factors in childhood and had the ability to follow those into adulthood. The purpose this enable pooling data increase power, most importantly for follow-up CVD events Within consortium, we hope be able obtain on independent effects early adult levels subsequent occurrence.
Extracts of the hops plant have been shown to reduce weight and insulin resistance in rodents humans, but elucidation mechanisms responsible for these benefits has hindered by use heterogeneous hops-derived mixtures. Because hop extracts are used as flavoring agents their bitter properties, we hypothesized that taste receptors (Tas2rs) could be mediating beneficial effects metabolic disease. Studies exposure cultured enteroendocrine cells tastants can stimulate release hormones, including...
The relationship between body fat indexes, lipid and lipoprotein levels, blood pressure was studied in 2230 children, each examined during 1973, 1976, 1978. children were grouped with the use of seven percentile (P) intervals triceps skinfold thickness that specific for race, sex, age; cardiovascular risk factor variables assessed over time. Of 238 initially lowest P group (less than 15P), 44% remained there, 65% had thicknesses below 30P on three occasions. 352 highest (greater or equal to...