A5101472836- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Adenosine and Purinergic Signaling
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Cardiovascular Effects of Exercise
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Studies on Chitinases and Chitosanases
- Neuroendocrine Tumor Research Advances
- S100 Proteins and Annexins
- Advanced biosensing and bioanalysis techniques
- Nerve injury and regeneration
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- TGF-β signaling in diseases
- Gastric Cancer Management and Outcomes
Peking University
2018-2025
Peking University Cancer Hospital
2018-2025
Xuzhou Medical College
2025
Second People’s Hospital of Huai’an
2025
Anhui Medical University
2022-2024
Second Hospital of Anhui Medical University
2024
Tongji University
2015-2023
Shanghai Pulmonary Hospital
2021-2023
Fuyang Second People's Hospital
2023
Tongde Hospital of Zhejiang Province
2023
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment the utility SNP data for predicting efficacy RA patients was performed context a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled comparative evaluation predictions developed by...
170 Background: This is a randomized, double-blind, multicenter phase 2/3 study comparing the efficacy and safety of serplulimab (a novel anti-PD-1 antibody) plus bevacizumab XELOX chemotherapy vs. placebo as first-line treatment for metastatic colorectal cancer (mCRC). Our previous presentation at 2024 ASCO Meeting showed progression-free survival results. Here we present updated findings together with subgroup analysis results after median follow-up 31.0 months. Methods: A total 114...
Abstract Pirtobrutinib, a highly selective, noncovalent (reversible) Bruton tyrosine kinase inhibitor (BTKi), demonstrated clinically meaningful antitumor responses in covalent BTKi pretreated mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) or small (SLL) the global phase 1/2 BRUIN study. In this multi‐center, open‐label, 2 trial, we investigated efficacy safety of pirtobrutinib Chinese patients with relapsed/refractory (R/R) MCL, CLL/SLL, other B‐cell malignancies. All...
Background Immunotherapies may prolong the survival of patients with small-cell lung cancer (SCLC) to some extent. The role forkhead box protein P3 (FOXP3) in tumor microenvironment (TME) remains controversial. We aimed examine FOXP3-related expression characteristics and prognostic values develop a clinically relevant predictive system for SCLC. Methods enrolled 102 histologically confirmed SCLC at stages I–III. Through immunohistochemistry, we determined pattern FOXP3 its association other...
Recent studies have indicated that pyroptosis may participate in the regulation of tumorigenesis and immune microenvironment. However, role pyroptosis-related genes (PRGs) pancreatic adenocarcinoma (PAAD) remains unclear. Through multiple bioinformatics analysis, we constructed a prognostic gene model competing endogenous RNA network. The correlation between PRGs prognosis, infiltration, checkpoints, tumor mutational burden was analyzed by Kaplan-Meier curve, univariate Cox, multivariate...
Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated role YAP pathological process cardiac matrix remodeling. A classic model DCM was established BALB/c mice by immunization with porcine myosin. Cardiac fibroblasts were isolated from neonatal Sprague-Dawley rats density gradient centrifugation. The...
Background Immunotherapy has revolutionized therapeutic patterns of small cell lung cancer (SCLC). Human leukocyte antigen class II (HLA II) is related to antitumor immunity. However, the implications HLA in SCLC remain incompletely understood. Materials and methods We investigated expression on tumor cells tumor-infiltrating lymphocytes (TILs) by immunohistochemistry staining its association with clinical parameters, immune markers, recurrence-free survival (RFS) 102 patients stage I–III...
Abstract Objective Endobronchial ultrasound‐guided transbronchial needle aspiration ( EBUS‐TBNA ) is commonly used for clinical diagnosis of mediastinal lymphadenectasis. This study aimed to evaluate the diagnostic significance lymphadenectasis in a large single center. Methods A total 846 patients who were not definitively diagnosed with underwent retrospectively analyzed this study. Results In total, 842 successfully. There 589 malignancy, including squamous carcinoma (118 cases; 20.6%),...
The interaction between cancer cells and stromal has a significant contribution in tumorigenesis tumor development, plays an anti-tumor immune effect under the regulation of drug resistance-related genes, which affects outcome patients. Coiled-coil domain-containing protein 73 (CCDC73), DLG associated 1 (DLGAP1), dermatan sulfate epimerase like (DSEL), estrogen receptor (ESR1), SEC14-like 5 (SEC14L5) were identified as genes lung cancer. However, these have no clear value terms expression...
7529 Background: Penpulimab is a humanized IgG1 monoclonal antibody (mAb) that blocks PD-1 binding to PD-L1. Penpulimab, with its unique epitope, was engineered eliminate Fc-mediated effector function compromises anti-tumor immune cell function, and optimize receptor occupancy by improving duration of drug binding. functions, such as ADCC/ADCP, have been observed in most IgG4 anti-PD-1 mAbs but absent penpulimab, thereby potentially reducing the occurrence immune-related adverse reactions....
Previous studies have revealed the significant roles of SHC SH2 domain-binding protein 1 (SHCBP1) in occurrence and progression cancers, but there is no pan-cancer analysis SHCBP1.In this study, we explored potential carcinogenic role SHCBP1 across 33 tumors from TCGA GTEx databases. We investigated expression, prognosis, genetic alterations, tumor mutational burden (TMB) score, microsatellite instability (MSI) microenvironment TIMER2, GEPIA2, UALCAN cBioPortal Moreover, cellular functions...
Nowadays, immune checkpoint blockades (ICBs) have been extensively applied in non-small cell lung cancer (NSCLC) treatment. However, the outcome of anti-program death-1/program death ligand-1 (anti-PD-1/PD-L1) therapy is not satisfying EGFR-mutant adenocarcinoma (LUAD) patients and its exact mechanisms fully understood. Since tumor mutation burden (TMB) phenotype had thought as potential predictors for efficacy ICBs, we further studied TMB LUAD to explore poor ICBs EGFR positive mutated find...
<h3>Background</h3> Penpulimab is a humanized IgG1 mAb that blocks PD-1 binding to PD-L1. was engineered eliminate Fc?R and ADCC/ADCP completely, as compared majority of marketed IgG4 antibodies with activity. effects can induce T-cell apoptosis clearance then compromise anti-tumor The removal eliminates Fc receptor mediated immune-cell recruitment activation could potentially reduce immune-related adverse reactions. demonstrated slower antigen off-rate than antibodies, which result in...
<title>Abstract</title> <bold>Background: </bold>Obesity increases the risk of kidney injury, involving various pathological events such as inflammation, insulin resistance, lipid metabolism disorders, and hemodynamic changes, making it a significant factor for development progression chronic disease. Diosmin, natural flavonoid glycoside, exhibits anti-inflammatory, antioxidant, anti-lipid, vasodilatory effects. However, whether diosmin has protective effect on obesity-related injury remains...
Background: Small cell lung cancer (SCLC) is a common subtype of cancer, and there currently no established method for the early identification SCLC. We prepared novel rare-earth near-infrared (NIR) downconversion nanoprobe to identify SCLC cells. Methods: The shell precursors Gd-OA Na-TFA-OA were prepared, NaYF 4 :Nd@NaGdF -ProGRP antibody probe was obtained after synthesizing fluorescent nanocrystals. used NIR cells subcutaneous tumors in nude mice. biotoxicity mice studied. Results:...
Small-cell lung cancer (SCLC) has poor prognosis and is prone to drug resistance. It necessary search for possible influencing factors SCLC chemotherapy insensitivity. Therefore, we proposed an mRNA network track the insensitivity in SCLC. Six samples of patients with were recruited RNA sequencing. TopHat2 Cufflinks used make differential analysis. Functional analysis was applied as well. Finally, multidimensional validation verifying results obtained by experiment. This study a trial...