A5100754054- Dermatologic Treatments and Research
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Connective Tissue Growth Factor Research
- dental development and anomalies
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Bone and Dental Protein Studies
- Reconstructive Surgery and Microvascular Techniques
- Tissue Engineering and Regenerative Medicine
- Bone fractures and treatments
- Laser Applications in Dentistry and Medicine
- Oral and gingival health research
- HER2/EGFR in Cancer Research
- Neurogenesis and neuroplasticity mechanisms
- Silk-based biomaterials and applications
- Botulinum Toxin and Related Neurological Disorders
- Cell Adhesion Molecules Research
- CAR-T cell therapy research
- Curcumin's Biomedical Applications
- Nerve injury and regeneration
- Sirtuins and Resveratrol in Medicine
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Inflammasome and immune disorders
North China University of Science and Technology
2023
Air Force Medical University
2012-2021
Xijing Hospital
2009-2021
Shanxi Provincial Cancer Hospital
2020
Jinan Stomatological Hospital
2018-2020
Zhejiang University
2018
People's Liberation Army 401 Hospital
2007-2014
Chinese People's Liberation Army
2009-2011
People's Liberation Army No. 150 Hospital
2010-2011
Henan Psychiatric Hospital
2006
Abstract Background Hypertrophic scar (HS) is a fibro-proliferative disorder of dermis after burn or trauma and usually leads to esthetic disfiguration functionary impairment for patients. Emerging evidences demonstrated ADSC-Exo could alleviate the visceral fibrosis, but little attention had been paid its role in skin fibrosis. In study, we would explore effect on HS investigated exact mechanism underlying properties. Methods were isolated, identified, internalized by HS-derived fibroblasts...
Abstract Background Hypertrophic scars (HS) generally occur after injury to the deep layers of dermis, resulting in functional deficiency for patients. Growing evidence has been identified that supernatant adipose tissue-derived stem cells (ADSCs) significantly ameliorates fibrosis different tissues, but limited attention paid its efficacy on attenuating skin fibrosis. In this study, we explored effect and possible mechanism ADSC-conditioned medium (ADSC-CM) HS. Method Real-time quantitative...
Background The hypertrophic scar (HS) is a serious fibrotic skin condition and major clinical problem. Interleukin-10 (IL-10) has been identified as prospective scar-improving compound based on preclinical trials. Our previous work showed that IL-10 anti-fibrotic effects in transforming growth factor (TGF)-β1-stimulated fibroblasts, well potential therapeutic benefits for the prevention reduction of formation. However, relatively little known about mechanisms underlying IL-10-mediated...
MicroRNA-199a (miR-199a) is a novel gene regulator with an important role in inflammation and lung injury. However, its the pathogenesis of sepsis-induced acute respiratory distress syndrome (ARDS) currently unknown. Our study explored miR-199a ARDS mechanism action. First, we found that LPS could upregulate alveolar macrophages. Downregulation inhibited upregulation inflammatory cytokines macrophages induced remission histopathologic changes, reduction proinflammatory cytokines, apoptosis...
The NLRP3 inflammasome is necessary for initiating acute sterile inflammation. However, its role in the pathogenesis of burn‐induced lung injury (ALI) unknown. This study aimed to determine and signaling pathways involved ALI. We observed that rat lungs exhibited enhanced activity after burn, as evidenced by increased levels expression Caspase‐1 augmented inflammatory cytokines. Inhibition BAY11‐7082 attenuated ALI, demonstrated concomitant remission histopathologic changes reduction...
Keloids, partially considered as benign tumors, are characterized by the overgrowth of fibrosis beyond boundaries wound and regulated mainly transforming growth factor (TGF)-β1, which induces transition fibroblasts to myofibroblasts. Hypoxia is an important driving force in development lung liver activating hypoxia inducible factor-1α stimulating epithelial‑mesenchymal transition. However, it unknown whether can influence human dermal scarring. The aim this study was investigate drives...
Abnormally high activation of transforming growth factor-β (TGF-β) signaling has been demonstrated to be involved in the initiation and progression keloids. However, functional role long non-coding RNA (lncRNA)-activated by TGF-β (lncRNA-ATB) keloids not documented. Here we investigated lncRNA-ATB autocrine secretion keloid fibroblasts (KFs) explored underlying molecular mechanism. Using immunohistochemistry quantitative RT-PCR analysis, showed that ZNF217, a transcriptional activator TGF-β,...
Sepsis is defined as a systemic inflammatory response syndrome that disorders the functions of host immune system, including imbalance between pro- and anti-inflammatory responses mediated by macrophages. could also induce acute hyperglycemia. Studies have shown silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, mediates NF-κb deacetylation inhibits its function. Therefore, SIRT1 likely to play important role in high glucose-mediated signalings....
Background and Purpose Sirtuin1 (SIRT1), the founding member of mammalian class III histone deacetylases, is reported to be a drug target involved in fibrotic diseases. However, whether it an effective hypertrophic scar treatment still not known. Experimental Approach In present study, we observed that SIRT1 localized both epidermis dermis skin tissues by immunohistochemistry. After knock‐down shRNA or up‐regulating resveratrol, expression α‐SMA, Col1 Col3 fibroblasts were detected western...
Wound healing is a highly orchestrated, multistep process, and delayed wound significant symptomatic clinical problem. Keratinocyte migration re-epithelialization play the most important roles in healing, as they determine rate of healing. In our previous study, we found that Src, one oldest proto‑oncogenes encoding membrane-associated, non-receptor protein tyrosine kinase, promotes keratinocyte migration. We therefore hypothesized Src through enhanced order to test this hypothesis, vectors...
Bone marrow mesenchymal stem cells (BMSCs), which have the ability to self-renew and differentiate into multiple cell types, recently become a novel strategy for cell-based therapies. The differentiation of BMSCs keratinocytes may be beneficial patients with burns, disease, or trauma. However, currently available are exposed animal materials during their cultivation induction. These xeno-contaminations severely limit clinical outcomes. Previous studies shown that Rho kinase (ROCK) inhibitor...
Oxidative stress plays an important role in burn‐induced myocardial injury, but the cellular mechanisms that control reactive oxygen species (ROS) production and scavenging are not fully understood. This study demonstrated blockade of Notch signaling via knockout transcription factor RBP‐J or a pharmacological inhibitor aggravated postburn which manifested as deteriorated serum CK, CK‐MB, LDH levels increased apoptosis vitro vivo . Interruption intracellular ROS production, scavenger...
Abstract Recent microRNA expression profiling studies have documented an up-regulation of miR-146a in several angiogenesis models. However, the underlying molecular mechanism angiogenic activity endothelial cells has not been clearly elucidated. The present study was aimed to evaluate whether promotes HUVECs by increasing FGFBP1 via directly targeting CREB3L1. over expressed lentiviral-miR-146a. Expression analysis found resulted and cytokine associated genes including FGF2. Further a...
Abstract Background Hypertrophic scar is a common complication in would healing process, and how to effectively prevent treat it has been hot difficult research issue. Previous studies have showed that botulinum toxin type A (BTA) effects on the prevention treatment of hypertrophic scar, but little known about specific mechanisms. Objective This study aimed explore potential mechanisms BTA inhibition formation. Methods scar‐derived human fibroblasts were cultured then treated with...