A5041130613- Adipose Tissue and Metabolism
- Wound Healing and Treatments
- Autophagy in Disease and Therapy
- Trace Elements in Health
- Ferroptosis and cancer prognosis
- Diabetic Foot Ulcer Assessment and Management
- Immune Response and Inflammation
- Occupational and environmental lung diseases
- Cardiovascular Function and Risk Factors
- Sirtuins and Resveratrol in Medicine
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Sepsis Diagnosis and Treatment
- Burn Injury Management and Outcomes
- Complementary and Alternative Medicine Studies
- Renin-Angiotensin System Studies
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Iron Metabolism and Disorders
- T-cell and Retrovirus Studies
- Cell death mechanisms and regulation
- GDF15 and Related Biomarkers
- Acute Myocardial Infarction Research
- NF-κB Signaling Pathways
- Immunotoxicology and immune responses
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
Southern Medical University
2018-2024
Nanfang Hospital
2018-2024
University of Wyoming
2012-2022
Qiqihar Medical University
2021
Air Force Medical University
2008-2017
Xijing Hospital
2008-2017
Yuhuangding Hospital
2012-2014
Cincinnati Children's Hospital Medical Center
2013
Abstract Background Hypertrophic scars (HS) generally occur after injury to the deep layers of dermis, resulting in functional deficiency for patients. Growing evidence has been identified that supernatant adipose tissue-derived stem cells (ADSCs) significantly ameliorates fibrosis different tissues, but limited attention paid its efficacy on attenuating skin fibrosis. In this study, we explored effect and possible mechanism ADSC-conditioned medium (ADSC-CM) HS. Method Real-time quantitative...
Lipopolysaccharide (LPS) provokes severe inflammation and cell death in sepsis, with liver being the major affected organ. Up-to-date, neither mechanism of action nor target treatment is readily available for LPS-induced injury. This study examined effect irisin, an endogenous hormonal peptide, on injury using animal models, involved a special focus pyroptosis. Irisin known to regulate glucose metabolism, inflammation, immune response, while our earlier work denoted anti-inflammatory...
Irisin plays a protective effect in acute and chronic myocardial damage, but its role septic cardiomyopathy is unclear. The aim of our study was to explore the vivo vitro effects irisin using an LPS-induced model. Our results demonstrated that treatment attenuated LPS-mediated cardiomyocyte death dysfunction. At molecular level, LPS application associated with mitochondrial oxidative injury, ATP depletion caspase-related apoptosis activation. In contrast, sustained function by inhibiting...
Sepsis is defined as a systemic inflammatory response syndrome that disorders the functions of host immune system, including imbalance between pro- and anti-inflammatory responses mediated by macrophages. could also induce acute hyperglycemia. Studies have shown silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, mediates NF-κb deacetylation inhibits its function. Therefore, SIRT1 likely to play important role in high glucose-mediated signalings....
Ureteral avulsion is a rare but serious complication of ureteroscopic lithotomy. As common treatment for long segment ureteral avulsion, ileal replacement has many complications, such as anastomotic site stricture and retrograde infection, prolonged exposure the intestinal mucosa to urine may result in postoperative metabolic acidosis. Autologous tissue becoming increasingly popular ureteroplasty, including oral mucosa, appendix bladder. Recent advancements reconstruction techniques have...
Background The colonization of burn wounds by Pseudomonas aeruginosa can lead to septic shock, organ injuries, and high mortality rates. We hypothesized that negative pressure wound therapy (NPWT) would decrease invasion proliferation P. within the reduce mortality. Methods Thermal injuries were induced in anesthetized mice, was applied surface for 24 h. After removing eschar debridement, animals subjected either NPWT or wet-to-dry (WTD) treatment protocols. bacterial loads on assessed...
Background and Purpose Lipopolysaccharides (LPS), an outer membrane component of Gram‐negative bacteria, triggers myocardial anomalies in sepsis. Recent findings indicated a role for inflammatory cytokine MIF its receptor, CD74, septic organ injury, although little is known the MIF‐CD74 cardiomyopathy. Experimental Approach This study evaluated impact CD74 ablation on endotoxaemia‐induced cardiac anomalies. Echocardiographic, cardiomyocyte contractile intracellular Ca 2+ properties were...
Hydrogen sulfide (H2S) is a toxic gas now being recognized as an endogenous signaling molecule in multiple organ systems, particular, the cardiovascular system. H2S known to regulate cardiac function and protect against ischemic injury. However, little information available regarding effect of on insulin resistance. This study was designed examine impact supplementation using Akt2 knockout model Wild-type mice were treated with NaHS (50 μM·kg(-1)·day(-1) ip for 10 days) prior evaluation...