Sainan Chen

ORCID: 0000-0003-2926-5785
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About
Contact & Profiles
Research Areas
  • Groundwater and Isotope Geochemistry
  • Iterative Learning Control Systems
  • Microgrid Control and Optimization
  • Hydrology and Watershed Management Studies
  • Soil and Water Nutrient Dynamics
  • Fish Ecology and Management Studies
  • Advanced Adaptive Filtering Techniques
  • Vibration and Dynamic Analysis
  • GDF15 and Related Biomarkers
  • Sepsis Diagnosis and Treatment
  • Autophagy in Disease and Therapy
  • Marine and coastal ecosystems
  • Karst Systems and Hydrogeology
  • Aquatic Ecosystems and Phytoplankton Dynamics
  • Inflammasome and immune disorders
  • Multilevel Inverters and Converters
  • Advanced Battery Technologies Research
  • Stress Responses and Cortisol
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Geology and Paleoclimatology Research
  • Cytokine Signaling Pathways and Interactions
  • Mitochondrial Function and Pathology
  • Lymphoma Diagnosis and Treatment
  • IgG4-Related and Inflammatory Diseases
  • Cancer, Stress, Anesthesia, and Immune Response

Tianjin University
2019-2024

Southern Medical University
2019-2024

Nanjing University of Aeronautics and Astronautics
2022-2024

Zhujiang Hospital
2021-2024

Nanjing Medical University
2015-2024

Shanghai Changzheng Hospital
2022-2023

North China University of Water Resources and Electric Power
2010-2023

Zhongyuan University of Technology
2018-2022

Second Military Medical University
2022

Fujian Academy of Medical Sciences
2021

Lipopolysaccharide (LPS) provokes severe inflammation and cell death in sepsis, with liver being the major affected organ. Up-to-date, neither mechanism of action nor target treatment is readily available for LPS-induced injury. This study examined effect irisin, an endogenous hormonal peptide, on injury using animal models, involved a special focus pyroptosis. Irisin known to regulate glucose metabolism, inflammation, immune response, while our earlier work denoted anti-inflammatory...

10.1080/10799893.2020.1808675 article EN Journal of Receptors and Signal Transduction 2020-08-19

The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet been completely clarified. Disease-specific treatments are lacking, and care is still based on supportive modalities. aim of our study was to assess the protective effects melatonin cardiomyopathy, with a focus interactions between receptor-interacting protein kinase 3 (Ripk3), mitochondria, endoplasmic reticulum (ER) cytoskeletal degradation in cardiomyocytes. Ripk3 expression increased heart samples...

10.1016/j.redox.2019.101287 article EN cc-by-nc-nd Redox Biology 2019-07-27

Phase lead compensation precision dramatically affects the performance of a repetitive controller (RC). Integer order phase proportional integral multiresonant type RC (PIMR-RC) with low sampling frequency cannot meet need fine compensation. In addition, digital control delay actual modeling system, and then influences To finely compensate lag PIMR-RC this article proposes fractional scheme based on novel infinite impulse response (IIR) filter. Its comprehensive synthesis is systematically...

10.1109/tie.2022.3212433 article EN IEEE Transactions on Industrial Electronics 2022-10-14

A proportional integral multiresonant-type repetitive control (PIMR-type RC) has not only a better harmonic suppressing performance but also faster error convergence rate. However, the harmonics of PIMR-type RC will significantly decrease when grid fundamental frequency fluctuates in large range. In this paper, an improved adaptive (FA-PIMR-type is proposed to cope with fluctuation The based on fractional delay filter, which can be approximately realized by finite impulse response filter....

10.1109/access.2018.2878416 article EN cc-by-nc-nd IEEE Access 2018-01-01

The Yellow River is difficult to control. Little water and a large amount of sediment results in accumulation its lower reaches as inflow exceeds transport capacity. Reducing this deposition essential for harnessing the River. Included process rational use sediment. Many researchers have investigated usage an aggregate material concrete production, but there are still some problems (e.g., low resource utilization strength made from sediment). To make up deficiency existing research, study...

10.3390/ma15165668 article EN Materials 2022-08-18

Since <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">LLC</i> converter is capable of naturally creating the soft-switching condition to improve overall efficiency, it widely used in dc–dc applications. Using resonant tank realize soft switching for three-phase ac–dc converters would be a very promising solution high efficiency and low cost conversion, an -based single-stage was configured by taking advantage voltage feature <inline-formula...

10.1109/tpel.2022.3140547 article EN IEEE Transactions on Power Electronics 2022-01-07

Filter-based active damping (AD) without additional sensors has been widely used in LCL-type grid-tied inverters. For the resonance problem of LCL filter, AD filter is devised through application amplitude shaping and/or phase according to Nyquist stability criterion. Although many robust filters have studied, there no attention paid whether harmonic content near resonant frequency meets grid standards. Besides, impact peak introduced by on inverters with unclear. Therefore, order explore...

10.1109/jestpe.2024.3375302 article EN IEEE Journal of Emerging and Selected Topics in Power Electronics 2024-03-11

Alcoholism leads to organ injury including mitochondrial defect and apoptosis with evidence favoring a role for autophagy dysregulation in alcoholic damage. Parkin represents an autosomal recessive inherited gene Parkinson's disease important member of selective mitochondria. The association between remains elusive. This study aimed examine the effect parkin deficiency on chronic alcohol intake-induced brain, liver skeletal muscle (rectus femoris muscle). Adult parkin-knockout (PRK-/-)...

10.1093/abbs/gmaa041 article EN Acta Biochimica et Biophysica Sinica 2020-04-01

To get better control performance in motor control, more and researches tend to apply non-linear laws the field of control. However, most conventional theory is based on explicit model controlled object often resulting complexity. Besides, parameters tuning mainly aiming at stability system. No valid direct performance-oriented has been proposed. Facing limitations, this paper presents a position an implicit data-driven manner. Unlike controls that are models with stability-based tuning,...

10.1109/access.2019.2937993 article EN cc-by IEEE Access 2019-01-01

Patients with pituitary neuroendocrine tumors (PitNETs) often experience neuropsychiatric disorders due to factors such as hormonal imbalances, and inadequate management of medications, surgeries, radiation therapies. Commonly observed include depression, anxiety, cognitive dysfunction, which significantly impact patients’ quality life prognosis. PitNETs have a significant presence immune cells within the tumor microenvironment (TME), predominantly macrophages T lymphocytes. These secrete...

10.3389/fnins.2024.1294417 article EN cc-by Frontiers in Neuroscience 2024-04-22
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