A5077293104- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Bioactive Natural Diterpenoids Research
- Hair Growth and Disorders
- Wound Healing and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Social Policy and Reform Studies
- Bone Metabolism and Diseases
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Policy Transfer and Learning
- Ideological and Political Education
- CAR-T cell therapy research
- Plant-based Medicinal Research
- Ion Transport and Channel Regulation
- Phytochemicals and Antioxidant Activities
- Biochemical Analysis and Sensing Techniques
- Mesenchymal stem cell research
- Nanoparticle-Based Drug Delivery
- Ginseng Biological Effects and Applications
- Neurological Disease Mechanisms and Treatments
- Skin Protection and Aging
- Phytochemical Studies and Bioactivities
- Sexual Differentiation and Disorders
Zhujiang Hospital
2025
Southern Medical University
2025
Air Force Medical University
2021-2024
Xijing Hospital
2021-2024
Shanghai Medical College of Fudan University
2024
Fudan University Shanghai Cancer Center
2024
Soochow University
2010-2023
First Affiliated Hospital of Soochow University
2020-2023
Fudan University
2019-2023
Shanghai Institute of Hematology
2019-2023
Abstract Hair follicle (HF) regeneration during wound healing continues to present a significant clinical challenge. Dermal papilla cell-derived exosomes (DPC-Exos) hold immense potential for inducing HF neogenesis. However, the accurate role and underlying mechanisms of DPC-Exos in remain be fully explained. This study, represents first analysis into effects on fibroblasts healing. Our findings demonstrated that could stimulate proliferation migration fibroblasts, more importantly, enhance...
Hypertrophic scarring is the most serious and unmet challenge following burn trauma injury often leads to pain, itching even loss of function. However, demand for ideal scar prevention treatment difficult satisfy. We aimed discover effects mechanisms adipose-derived stem cell (ADSC) exosomes in hypertrophic scarring. ADSC were isolated from culture supernatant ADSCs identified by nanoparticle tracking analysis, transmission electron microscopy western blotting. The effect on wound healing...
A bioactive ingredient in an ethanol extract from the branch bark of cultivated mulberry Husang-32 (Morus multicaulis Perr.) was isolated using a macroporous resin column. The primary component, which purified by semi-preparative high-performance liquid chromatography diode array detection (HPLC-DAD), identified as mulberroside (MA) chromatograph-mass spectrometer (LC-MS), 1H and 13C nuclear magnetic resonance (NMR) spectra. In total, 4.12 g MA efficiently extracted one kilogram bark....
Radiation-induced bone loss is a potential health concern for cancer patients undergoing radiotherapy. Enhanced resorption by osteoclasts and decreased formation osteoblasts were thought to be the main reasons. In this study, we showed that both pre-differentiating differentiating relatively sensitive X-rays compared with osteoblasts. cell viability greater degree in RAW264.7 cells than osteoblastic MC3T3-E1 cells. at up 8 Gy had little effects on osteoblast mineralization. contrast, 1...
Ischemia-reperfusion injury (IRI) is the main cause of acute kidney (AKI), and there no effective therapy. Microenvironmental acidification generally observed in ischemic tissues. Acid-sensing ion channel 1a (ASIC1a) can be activated by a decrease extracellular pH which mediates neuronal IRI. Our previous study demonstrated that, ASIC1a inhibition alleviates renal However, underlying mechanisms have not been fully elucidated. In this study, we determined that tubule-specific deletion mice...
Increased apoptosis of retinal ganglion cells (RGCs) contributes to the gradual loss neurons at early phase diabetic retinopathy (DR). There is an urgent need search for drugs with neuroprotective effects against RGCs treatment DR. This study aimed investigate saponins extracted from Panax notoginseng, a traditional Chinese medicine, on stimulated by palmitate, metabolic factor development diabetes and its complications, explore potential molecular mechanism. We showed that crude P....
Lipophilization of bortezomib with pinanediol enables efficacious drug loading and targeted tumor chemotherapy reduction-sensitive self-crosslinked micellar systems.
Abstract Acidic microenvironment is commonly observed in ischaemic tissue. In the kidney, extracellular pH dropped from 7.4 to 6.5 within 10 minutes initiation of ischaemia. Acid‐sensing ion channels (ASICs) can be activated by drops 7.0 or lower and permeates Ca 2+ entrance. Thus, activation ASIC1a mediate intracellular accumulation play crucial roles apoptosis cells. However, role ASICs renal injury unclear. The aim present study was test hypothesis that ischaemia increases epithelia cell...
Mixed phenotype acute leukemia (MPAL) is a rare and regarded as high-risk entity with poor prognosis. Induction therapy of an lymphoblastic type or hybrid regimen hematopoietic stem cell transplantation has been recommended for MPAL. However, the optimal therapies relapsed refractory MPAL remain unclear, especially relapse after transplantation. Donor-derived chimeric antigen receptor T (CAR-T) may be promising therapeutic option patients who express target antigens have recurrence remains...
Rabdosia japonica var. glaucocalyx (Maxim.) Hara, belonging to the Labiatae family, is widely used as an anti-inflammatory and antitumor drug for treatment of different inflammations cancers. Aim Study. To investigate therapeutic effects possible mechanism flavonoids fraction Hara (RJFs) in acute lung injury (ALI) mice induced by lipopolysaccharide (LPS). Materials Methods. Mice were orally administrated with RJFs (6.4, 12.8, 25.6 mg/kg) per day 7 days, consecutively, before LPS challenge....
Abstract Adverse‐risk acute myeloid leukemia (AML) has a dismal prognosis. We aimed to investigate the activity and tolerability of venetoclax combined with homoharringtonine (HHT) plus cytarabine (VHA) regimen for de novo adverse‐risk AML. Thirteen AML patients factors were treated (100 mg day 1, 200 2, 400 days 3‐21), HHT (1 mg/m 2 1‐5) (VHA regimen). Complete remission (CR) was achieved in 11/13 patient (84.6%), all CR responders measurable residual disease (MRD) negative detected by...
<title>Abstract</title> Hair follicle (HF) regeneration after skin injury remains a major clinical challenge. Dermal papilla cell-derived exosomes (DPC-Exos) have great potential to induce HF neogenesis. However, the role and mechanism of DPC-Exos in during wound healing are still unclear. In this study, effect on fibroblasts was explored for first time. We found that could promote proliferation migration fibroblasts, more importantly, enhance hair-inducing capacity fibroblasts. The treated...
This paper explores the role of policy transfer in establishing long-term care insurance China. The study shows that knowledge gained from Germany serves as a new instrument provision to elderly and disabled We build on theory Dolowitz Marsh framework Evans examine initiation process for insurance, which is arguably broadly indicative dynamics change underpinning incremental transfer. It observed current characterized by evidence-based policy-making. research implements tool innovation...
Background: Patients with hematologic malignancies have poor immunity, and they are more vulnerable to fungal invasion because of disease characteristics clinical treatment such as chemotherapy. Mucor infections in rare, but once occurred usually lead high mortality. In this study, we report two cases complicated breakthrough mucormycosis (BT-MCR), which were treated amphotericin B colloidal dispersion (ABCD) combined or without other antifungal agents. Case Presentation: 1 shows a patient...
This paper explores the initiation process of long-term care insurance (LTCI) policy in China’s social security sector, and focuses on policy-oriented learning activities to develop initiatives from German lessons. It presents a case LTCI pilot program, which serves as new product that provides elderly disabled upgrades sector’s performance. study implements construct an analytical framework applies it system. research suggests is rational tool used manufacture products enable intellectual...