A5016132929- Radiation Therapy and Dosimetry
- Cancer-related molecular mechanisms research
- Effects of Radiation Exposure
- RNA modifications and cancer
- Spaceflight effects on biology
- MicroRNA in disease regulation
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- Advanced Radiotherapy Techniques
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Cell Image Analysis Techniques
- Advanced Fluorescence Microscopy Techniques
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Plant Genetic and Mutation Studies
- Medical Imaging Techniques and Applications
- Radiation Effects and Dosimetry
Anhui Medical University
2024-2025
Soochow University
2016-2025
Northwest University
2025
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Southwest University
2023
Henan Provincial Institute of Cultural Heritage and Archaeology
2023
State Key Laboratory of Proteomics
2021-2022
Beijing Proteome Research Center
2018-2022
Beijing Radiation Center
2022
Fuzhou University
2020
Abstract The immunological implications of cuproptosis, a form cell death highly sensitive to oxygen presence, remain largely unexplored in the context tumor immunotherapy. Herein, we initially investigate positive correlation between cuproptosis and immunotherapy through bioinformatics analysis. Subsequently, an generator loaded with copper ions ( Cu/AP H‐M) has been constructed, which serves as effective carrier crucially enhances oxygenation microenvironment. Importantly, H‐M‐mediated...
Abstract Long noncoding RNAs (lncRNAs) in eukaryotic transcripts have long been believed to regulate various aspects of cellular processes, including carcinogenesis. Herein, it is found that lncRNA AFAP1‐AS1 encodes a conserved 90‐amino acid peptide located on mitochondria, named translated mitochondrial‐localized (ATMLP), and not the but promotes malignancy nonsmall cell lung cancer (NSCLC). As tumor progresses, serum level ATMLP increases. NSCLC patients with high levels display poorer...
Abstract Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding YAP, limiting...
Radiation therapy is a kind of tumor treatment that has been widely employed in clinics, but its therapeutic effect largely hampered by various factors. Currently, considerable efforts are being made the search for effective and safe radiosensitizers. A nano-radiosensitizer an ideal choice improving effects radiotherapy due to high degree tissue uptake secondary electrons' productivity. Herein, highly oxidized graphene quantum dots (GQDs) with good oxidative stress response significantly...
The construction and operation of synchrotron-generated radiation facilities (SRF) continues to grow, resulting in raising individual's exposure due an increased amount use, e.g., for medical diagnosis disease treatment, industrial applications, educational scientific researches. Space exploration missions space tourism are additional areas protracted low dose situations with types not present on the Earth. In contrast high doses ionizing radiation, cancer risk more commonly encountered or...
Cerium oxide nanoparticles (CeO2 NPs) have potential application for use in biomedical and various consumer products. However, it is largely unclear whether CeO2 NPs effects on male reproductive function.In this study, mice were examined toxicity, if any, following chronic oral administration of 32 days. In each animal, epididymides sperm motility DNA integrity. Bloods tested testosterone levels. Testicular tissues collected to determine the element Ce content, daily production (DSP), marker...
Different from conventional radiotherapy (CONV-RT), FLASH (FLASH-RT) delivers a single high dose at mean rate ≥40 Gy/s in milliseconds to achieve similar tumor control CONV-RT while sparing normal tissues detrimental injury. It provides an intriguing perspective improving clinical outcomes for patients as well novel way enhance the differential responses between and tissues. However, its mechanisms remain largely unclear. In this paper, we review currently available publications on FLASH-RT...
Radiation therapy (RT) plays an important role in cancer treatment. The clinical efficacy of radiation is, however, limited by normal tissue toxicity areas surrounding the irradiated tumor. Compared to conventional (CONV-RT) which doses are typically delivered at dose rates between 0.03–0.05 Gy/s, there is evidence that orders magnitude higher (known as FLASH-RT), dramatically reduces adverse side effects tissues while achieving similar tumor control. present study focused on cell response...
Phosphodiesterase type 5 inhibitors (PDE5is) constitute the primary therapeutic option for treating erectile dysfunction (ED). Nevertheless, a substantial proportion of patients, approximately 30%, do not respond to PDE5i treatment. Therefore, new treatment methods are needed. In this study, we identified pathway that contributes male function. We show mechano-regulated YAP/TAZ signaling in smooth muscle cells (SMCs) upregulates adrenomedullin transcription, which relaxed SMCs maintain...
The mechanisms of radiation-induced bystander effects (RIBE) have been investigated intensively over the past two decades. Although quite a few reports demonstrated that cytokines such as TGF-β1 are induced within directly irradiated cells and play critical roles in mediating effects, little is known about signaling pathways occur cells. crucial question to why RIBE signals cannot be infinitely transmitted, therefore, remains unclear. In present study, we showed miR-663, radiosensitive...
Aim of the Study To assess antidiarrheal properties Evodiamine in prevention and treatment Chemotherapy-Induced Diarrhea (CID) experimental rats. Materials Methods The Swiss albino female rats (8-12 weeks) were treated with for 13 days 5-FU was administered on day 4 to 10 (7 consecutive days) induction diarrhea. After experiments, all euthanized thymus spleen weights measured. Bodyweight diarrhea rate score recorded every day. Results Our study resulted that significantly prevented reduced...
Ferroptosis is an iron-dependent regulated form of cell death implicated in various diseases, including cancers, with its progression influenced by peroxidation phospholipids and dysregulation the redox system. Whereas extracellular matrix tumors provides mechanical cues influencing tumor initiation progression, impact on ferroptosis mechanisms remains largely unexplored. In this study, we reveal that heightened tension sensitizes cells to ferroptosis, whereas decreased mechanics confers...
Photon radiation has been shown to stimulate the secretion of radioresistant factors from tumor cells, ultimately promoting angiogenesis and metastasis. On other hand, heavy-ion radiotherapy demonstrated control metastasis levels. The molecular mechanisms responsible for different angiogenic responses photon irradiation are not fully understood. This study aims explore irradiation-responsive genes related reveal regulatory effect. In order clarify potential after X-ray or carbon ion (C-ion)...
The integration of photothermal therapy (PTT) with gene (GT) in a single nanoscale platform demonstrates great potential cancer therapy. Porous iron oxide nanoagents (PIONs) are widely used as magnetic the drug delivery field and also serve nanoagent for However, therapeutic efficacy PIONs-mediated GT has not been studied. long noncoding RNA (lncRNA) CRYBG3 (LNC CRYBG3), lncRNA induced by heavy ion irradiation lung cells, reported to directly bind globular actin (G-actin) cause degradation...
Hepatocellular carcinomas (HCCs) are characterized by frequent somatic genomic copy number alterations (CNAs), with most of them biologically unexplored. Here, we performed integrative analyses combining CNAs the transcriptomic data to reveal cis- and trans-effects in HCC. We identified recurrent gains chromosome 8q, which exhibit strong broadly associated ribosome biogenesis activity. Furthermore, 8q gain-driven overexpression regulator (RRS1) promotes growth HCC cells vitro vivo....
Diploid cells undergoing senescence and mitotic slippage have been reported in the literature. However, mechanisms triggering long-term G2-arrested are currently unclear. Previously, we that cell cycle of human uveal melanoma line, 92-1, is suspended for up to 6 d upon exposure 10 Gy ionizing radiation (IR), followed by senescence. In current study, initially distinguished blocked 92-1 from confirming blockage G2 phase. We subsequently showed genes essential G2-M transition prematurely...
Radiation-induced bone loss is a potential health concern for cancer patients undergoing radiotherapy. Enhanced resorption by osteoclasts and decreased formation osteoblasts were thought to be the main reasons. In this study, we showed that both pre-differentiating differentiating relatively sensitive X-rays compared with osteoblasts. cell viability greater degree in RAW264.7 cells than osteoblastic MC3T3-E1 cells. at up 8 Gy had little effects on osteoblast mineralization. contrast, 1...