A5057618650- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Nuclear Structure and Function
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- RNA Research and Splicing
- Plant Virus Research Studies
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Insect-Plant Interactions and Control
- Insect Resistance and Genetics
Soochow University
2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Chinese Academy of Agricultural Sciences
2017
Biotechnology Research Institute
2017
Abstract Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding YAP, limiting...
Ferroptosis is an iron-dependent regulated form of cell death implicated in various diseases, including cancers, with its progression influenced by peroxidation phospholipids and dysregulation the redox system. Whereas extracellular matrix tumors provides mechanical cues influencing tumor initiation progression, impact on ferroptosis mechanisms remains largely unexplored. In this study, we reveal that heightened tension sensitizes cells to ferroptosis, whereas decreased mechanics confers...
Chewing insects cause severe yield losses in crop production worldwide. Crop plants counteract chewing by transcriptionally promoting a repertoire of defense gene products that are either toxic to, or attractive to the natural enemies of, pest insects. However, complexity transcriptional reprogramming plant response against is still not well understood. In this study, genome-wide early responses maize seedlings Asian corn borer (ACB, Ostrinia furnacalis) and also jasmonic acid(JA), pivotal...
<p>Figure S1, Figure S2, S3, S4, S5, S6, S7, S8</p>
<p>Figure S1, Figure S2, S3, S4, S5, S6, S7, S8</p>
<div>Abstract<p>Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding...
<div>Abstract<p>Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding...