A5075670641- Hippo pathway signaling and YAP/TAZ
- CRISPR and Genetic Engineering
- PARP inhibition in cancer therapy
- Nuclear Structure and Function
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Single-cell and spatial transcriptomics
- Doping in Sports
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- Chromatin Remodeling and Cancer
- Skin Protection and Aging
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Sexual function and dysfunction studies
- Cancer-related molecular mechanisms research
Soochow University
2022-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Abstract Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding YAP, limiting...
Phosphodiesterase type 5 inhibitors (PDE5is) constitute the primary therapeutic option for treating erectile dysfunction (ED). Nevertheless, a substantial proportion of patients, approximately 30%, do not respond to PDE5i treatment. Therefore, new treatment methods are needed. In this study, we identified pathway that contributes male function. We show mechano-regulated YAP/TAZ signaling in smooth muscle cells (SMCs) upregulates adrenomedullin transcription, which relaxed SMCs maintain...
Ferroptosis is an iron-dependent regulated form of cell death implicated in various diseases, including cancers, with its progression influenced by peroxidation phospholipids and dysregulation the redox system. Whereas extracellular matrix tumors provides mechanical cues influencing tumor initiation progression, impact on ferroptosis mechanisms remains largely unexplored. In this study, we reveal that heightened tension sensitizes cells to ferroptosis, whereas decreased mechanics confers...
Abstract Mechanotransduction sensing of tissue architecture and cellular microenvironment is a fundamental regulator cell fate, including cancer. Meanwhile, long noncoding RNAs (lncRNAs) play multifunctions during cancer development treatment. However, the link between lncRNAs mechanotransduction in context progression has not yet been elucidated. In this study, using atomic force microscopy (AFM), we find that ionizing radiation reduces tumor stiffness. Ionizing radiation-induced lncRNA...
To investigate the substantial changes in cell types, pathways, and cell-cell interactions occurring irradiation-induced alopecia dermatitis (IRIAD) mouse model to identify potential targets for patients experiencing skin adverse reactions radiotherapy. Mice were irradiated at 15 Gy, targeting head neck region. After a 14-day interval, living cells extracted from both wild-type (WT) mice single-cell RNA sequencing (scRNA-seq). The scRNA-seq data, retrieved GEO database (GSE201447), underwent...
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<p>Figure S1, Figure S2, S3, S4, S5, S6, S7, S8</p>
<div>Abstract<p>Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding...
<div>Abstract<p>Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding...
To investigate the impact of SWI/SNF complex on heterochromatin DNA damage repair after exposure to X-ray irradiation, in order explore underlying mechanism. NIH3T3 and MRC5 cells were treated with 50 nmol/L siRNA targeting subunits (BRM, ARID1A, BRG1 SNF5), YAP/TAZ. At 24 h transfection, irradiated 0.5 1 Gy X-rays. 20, 60 240 min post-irradiation, γH2AX assay was performed evaluate radiation response total or heterochromatin. Comet used determine role YAP/TAZ when 4 BRM/BRG1 their...