A5031565021- PARP inhibition in cancer therapy
- CRISPR and Genetic Engineering
- Hippo pathway signaling and YAP/TAZ
- Nuclear Structure and Function
- DNA Repair Mechanisms
- Doping in Sports
- RNA Research and Splicing
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Sexual function and dysfunction studies
- Ubiquitin and proteasome pathways
Soochow University
2021-2024
The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
2024
Phosphodiesterase type 5 inhibitors (PDE5is) constitute the primary therapeutic option for treating erectile dysfunction (ED). Nevertheless, a substantial proportion of patients, approximately 30%, do not respond to PDE5i treatment. Therefore, new treatment methods are needed. In this study, we identified pathway that contributes male function. We show mechano-regulated YAP/TAZ signaling in smooth muscle cells (SMCs) upregulates adrenomedullin transcription, which relaxed SMCs maintain...
Abstract Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding YAP, limiting...
Ferroptosis is an iron-dependent regulated form of cell death implicated in various diseases, including cancers, with its progression influenced by peroxidation phospholipids and dysregulation the redox system. Whereas extracellular matrix tumors provides mechanical cues influencing tumor initiation progression, impact on ferroptosis mechanisms remains largely unexplored. In this study, we reveal that heightened tension sensitizes cells to ferroptosis, whereas decreased mechanics confers...
<p>Figure S1, Figure S2, S3, S4, S5, S6, S7, S8</p>
<p>Figure S1, Figure S2, S3, S4, S5, S6, S7, S8</p>
<div>Abstract<p>Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding...
<div>Abstract<p>Yes-associated protein (YAP) is a central player in cancer development, with functions extending beyond its recognized role cell growth regulation. Recent work has identified link between YAP/transcriptional coactivator PDZ-binding motif (TAZ) and the DNA damage response. Here, we investigated mechanistic underpinnings of cross-talk repair YAP activity. Ku70, key component nonhomologous end joining pathway to damage, engaged dynamic competition TEAD4 for binding...