A5100374672- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Natural product bioactivities and synthesis
- Animal Genetics and Reproduction
- MicroRNA in disease regulation
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Prenatal Screening and Diagnostics
- Chromosomal and Genetic Variations
- Heat shock proteins research
- RNA Research and Splicing
- Food composition and properties
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- TGF-β signaling in diseases
- Caveolin-1 and cellular processes
- Congenital heart defects research
- Virtual Reality Applications and Impacts
- Signaling Pathways in Disease
Chinese Academy of Agricultural Sciences
2009-2024
Agricultural Genomics Institute at Shenzhen
2022-2024
Ministry of Agriculture Livestock and Fisheries
2024
Ministry of Agriculture and Agro Based Industry
2024
Harbin Institute of Technology
2024
Soochow University
2016-2023
Second Affiliated Hospital of Soochow University
2016-2023
University of Science and Technology of China
2003-2022
Xintai People's Hospital
2021
Fanjingshan National Nature Reserve
2021
The genetic mechanisms that underlie phenotypic differentiation in breeding animals have important implications evolutionary biology and agriculture. However, the contribution of cis-regulatory variants to pig phenotypes is poorly understood. Therefore, our aim was elucidate molecular by which non-coding cause differences pigs combining analyses functional genomics.We obtained a high-resolution phased chromosome-scale reference genome with contig N50 18.03 Mb for Luchuan breed (a...
Abstract Long noncoding RNAs (lncRNAs) in eukaryotic transcripts have long been believed to regulate various aspects of cellular processes, including carcinogenesis. Herein, it is found that lncRNA AFAP1‐AS1 encodes a conserved 90‐amino acid peptide located on mitochondria, named translated mitochondrial‐localized (ATMLP), and not the but promotes malignancy nonsmall cell lung cancer (NSCLC). As tumor progresses, serum level ATMLP increases. NSCLC patients with high levels display poorer...
Abstract Background Chloride intracellular channel 1 (CLIC1) is expressed ubiquitously in human tissues and involved the regulation of cell cycle, proliferation differentiation. Recent studies have shown that CLIC1 highly several malignant tumors. However, its roles gliomas are still unclear. The aim this study was to investigate clinicopathological significance prognostic value expression gliomas. Methods nonneoplastic brain measured by real-time quantitative RT-PCR assay...
// Yan Chen 1, 2, * , Shai Huang Bo Wu 3, Jiankai Fang 2 Minsheng Zhu Li Sun 4 Lifeng Zhang 1 Yongsheng 5 Maomin Lingling Guo and Shouli Wang 6, 7 Department of Surgery, The First Affiliated Hospital Soochow University, Suzhou 215006, China Pathology, School Biology & Basic Medical Sciences, 215123, 3 People's Sihong County, 223900, Jiangsu Province, Laboratory Animal Research Center, University Medicine, Second 215004, 6 Molecular County Hospital, Key Tumor Microenvironment These authors...
Malignant glioma, the most common form of primary brain tumor, is associated with substantial morbidity and mortality, owing to lack response shown by patients conventional therapies. Additional therapeutic targets effective treatment options for these are therefore required. In present study, a possible association thioredoxin-interacting protein (TXNIP) malignant glioma was evaluated. Initially, semi-quantitative quantitative analysis expression levels TXNIP in clinical specimens performed...
Radiation-induced skin injury, which remains a serious concern in radiation therapy, is currently believed to be the result of vascular endothelial cell injury and apoptosis. Here, we established model acute radiation-induced compared effect different growth factors on healing by observing changes microcirculation Vascular factor (VEGF) was more effective at inhibiting apoptosis preventing progression than other factors. A new strategy for improving bioavailability developed loading VEGF...
We study the Faraday patterns generated by spin-orbit-coupling induced parametric resonance in a spinor Bose-Einstein condensate with repulsive interaction. The collective elementary excitations of condensate, including density waves and spin waves, are coupled as result Raman-induced spin-orbit coupling quench relative phase two Raman lasers without modulation any system's parameters. observed several higher tongues at integer multiples driving frequency investigated interplay between...
The sensory characteristics of Maillard reaction products from chicken protein hydrolysates (MRP-CPHs) at different degrees hydrolysis (DH) were evaluated using descriptive analysis. Five (boiled flavor, umami, mouthfulness, continuity and overall acceptance) the MRP-CPHs evaluated. In addition, changes in free amino acid contents molecular weight distribution (CPHs) also determined. results showed that attributes affected by DH CPHs, there was a distinct difference among almost all...
A derivative X chromosome formed by translocation involving an and a 18 in Klinefelter syndrome (KS) patient with 47,XXY karyotype has not been reported before. In this study, we present the clinical molecular cytogenetic characteristics. The presented small testes azoospermia. G-banding analysis identified as 47,XY,del(X)(p?11.4). Array CGH detected 10.36-Mb duplication of region 18p11.22p11.32 (14,316-10,377,516) 111.18-Mb Xp11.4q28 (61,931, 689-155,111,583), addition to normal chromosome....
// Liang Wang 1, * , Gang Li Nan Liu 2, Zhen 2 Xiaoshan Xu Jing Qi Dongni Ren Pengxing Zhang Yongsheng 3 Yanyang Tu 1 Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China Experimental Surgery, Administrative, These authors have contributed equally to this work Correspondence to: Tu, email: tu.fmmu@gmail.com Zhang, zhangys_td@163.com Keywords: SOX9, gliomas, polymorphism, genetic susceptibility Received: June 17,...
The genetic underpinnings of phenotypic differentiation during animal breeding has important implications in both evolutionary biology and agriculture. However, how cis-regulatory variants influence pig phenotypes is not well understood. Here, we present a high-resolution phased chromosome-scale reference genome with contig N50 18.03 Mb for Luchuan (a representative Eastern breed), profiled potential selective sweeps Western pigs by re-sequencing 234 pigs. In these regions, multi-tissue...