A5066381145- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Muscle Physiology and Disorders
- RNA regulation and disease
- Barrier Structure and Function Studies
- Caveolin-1 and cellular processes
- Kruppel-like factors research
- Extracellular vesicles in disease
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Plant Molecular Biology Research
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Insect-Plant Interactions and Control
- Molecular Biology Techniques and Applications
- Plant Stress Responses and Tolerance
Chinese Academy of Agricultural Sciences
2015-2025
Agricultural Genomics Institute at Shenzhen
2019-2025
China Medical University
2012-2025
Hunan University of Arts and Science
2025
Huazhong Agricultural University
2021-2024
Linyi University
2024
Ministry of Agriculture Livestock and Fisheries
2024
Ministry of Agriculture and Agro Based Industry
2024
University of Michigan
2023
Tibet University
2018-2022
// Jing Ke 1, 2 , Yi-long Yao 3 Jian Zheng Ping Wang Yun-hui Liu Jun Ma Zhen Li Xiao-bai Zhi-qing Zhen-hua 4 Yi-xue Xue 1 Department of Neurobiology, College Basic Medicine, China Medical University, Shenyang 110122, Institute Pathology and Pathophysiology, Neurosurgery, Shengjing Hospital 110004, Physiology, Correspondence to: Xue, e-mail: xueyixue888@163.com Keywords: lncRNA, HOTAIR, miR-326, glioma, FGF1 Received: February 07, 2015 Accepted: June 17,...
Abstract Drought stress significantly impacts global rice production, highlighting the critical need to understand genetic basis of drought resistance in rice. Here, through a genome-wide association study, we reveal that natural variations DROUGHT RESISTANCE GENE 9 ( DRG9 ), encoding double-stranded RNA (dsRNA) binding protein, contribute resistance. Under stress, condenses into granules (SGs) liquid-liquid phase separation via crucial α-helix. recruits mRNAs OsNCED4 , key gene for...
High temperatures cause huge yield losses in rice. Heat-shock factors (Hsfs) are key transcription which regulate the expression of heat stress-responsive genes, but natural variation and functional characterization Hsfs have seldom been reported. A significant response locus was detected via a genome-wide association study (GWAS) using green leaf area as an indicative trait. miniature inverted-repeat transposable element (MITE) promoter candidate gene, HTG3 (heat-tolerance gene on...
The genetic mechanisms that underlie phenotypic differentiation in breeding animals have important implications evolutionary biology and agriculture. However, the contribution of cis-regulatory variants to pig phenotypes is poorly understood. Therefore, our aim was elucidate molecular by which non-coding cause differences pigs combining analyses functional genomics.We obtained a high-resolution phased chromosome-scale reference genome with contig N50 18.03 Mb for Luchuan breed (a...
MicroRNAs have recently emerged as key regulators of cancers. This study was therefore conducted to investigate the role miR-330 in biological behaviors human glioblastoma U87 and U251 cell lines its molecular mechanism. SH3GL2 gene identified target miR-330. MiR-330 overexpression established by transfecting precursor into cells, effects on proliferation, migration, invasion, cycle apoptosis were studied. Overexpression can enhance cellular promote migration activate also inhibit cells....
Blood-tumor barrier (BTB) constitutes an efficient organization of tight junctions that impairs the delivery therapeutic drugs. However, methods and molecular mechanisms underlying BTB opening remain elusive. MicroRNAs (miRNAs) have recently emerged as key regulators various biologic processes targets. In this study, we identified microRNA-181a (miR-181a) a critical miRNA in BTB. MicroRNA-181a expression was upregulated glioma endothelial cells (GECs), which were obtained by coculturing...
Great interest persists in useful therapeutic targets glioblastoma (GBM). Deregulation of microRNAs (miRNAs) expression has been associated with cancer formation through alterations gene targets. In this study, we reported the role miR-101 human stem cells (GSCs) and potential mechanisms.Quantitative real-time PCR showed that was decreased GSCs. Overexpression reduced proliferation, migration, invasion, promoted apoptosis One direct target miR-101, transcription factor Kruppel-like 6 (KLF6),...
N6-methyladenosine (m6A) represents the most abundantly occurring mRNA modification and is involved in regulation of skeletal muscle development. However, status function m6A methylation prenatal myogenesis remains unclear. In this study, we first demonstrated that knockdown METTL14, an methyltransferase, inhibited differentiation promoted proliferation C2C12 myoblast cells. Then, using a refined m6A-specific methylated RNA immunoprecipitation (RIP) with next generation sequencing...
MicroRNAs are currently considered as an active and rapidly evolving area for the treatment of tumors. In this study, we elucidated biological significance miR-330 in glioblastoma stem cells (GSCs) well possible molecular mechanisms. SH3GL2 is mainly distributed central nervous system to be a tumor suppressor many present identified potential regulator found that it was inversely correlated with expression GSCs which were isolated from U87 cell lines. The enhanced cellular proliferation,...
The concurrent presence of algal blooms and microplastics pollution in natural water bodies poses a novel threat. However, the joint effects microcystin-LR (MCLR) combination with polystyrene (PSMPs) on thyroid endocrine system adult fish remains unclear. In our study, male zebrafish (Danio rerio) were exposed to environmentally relevant concentrations MCLR alone (0, 0.8, 4, 20 μg/L) mix PSMPs (100 for 60 days. Alterations brain histology, hormone (TH) levels, transcription levels...
This study aimed to investigate the feasibility, acceptability, and preliminary efficacy of a ventriculosagittal sinus (VSS) shunt in treatment hydrocephalus with elevated cerebrospinal fluid (CSF) protein content. In this single-center retrospective analysis, we enrolled 80 patients CSF levels. Based on these procedures, primary cohort was divided into two groups using (CSFP) for subsequent analysis determine relationship between clinical effect CSFP. Preoperative postoperative computer...
Long non-coding RNAs (lncRNAs) regulate liquid-liquid phase separation (LLPS), driving the formation of biomolecular condensates essential for cellular function. However, this regulatory mechanism is yet to be reported in skeletal muscles. In study, we comprehensively analyzed lncRNAs muscle across multiple pig breeds, developmental stages, and tissues. Our analysis identified over 10,000 novel lncRNAs. We found that lnc-regulator growth (lnc-RMG) regulates myogenesis by modulating LLPS Meis...
Abstract Skeletal muscle plays a crucial role in maintaining motor function and metabolic homeostasis, with its loss or atrophy leading to significant health consequences. Long non‐coding RNAs (lncRNAs) have emerged as key regulators biology; however, their precise roles pathology remain be fully elucidated. This study demonstrates that lncRNA maternally expressed gene 3 (MEG3) is preferentially slow‐twitch fibers dynamically regulated during development, aging, the context of Duchenne...
Skeletal muscle plays critical roles in providing a protein source and contributing to meat production. It is well known that microRNAs (miRNAs) exert important effects on various biological processes muscle, including cell fate determination, fiber morphology, structure development. However, the role of miRNA skeletal development remains incompletely understood. In this study, we observed miRNA, miR-24-3p, which exhibited higher expression levels Tongcheng (obese-type) pigs compared...
Artemether is the derivative extracted from Chinese traditional herb and originally used for malaria. also has potential therapeutic effects against tumors. Vascular cell adhesion molecule-1 (VCAM-1) an important surface molecule associated with malignancy of gliomas. In this work, we investigated role mechanism artemether combined shRNA interference VCAM-1 (shRNA-VCAM-1) on migration, invasion apoptosis glioma cells. U87 human cells were treated at various concentrations interfering...