A5100731404- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- RNA Research and Splicing
- Toxin Mechanisms and Immunotoxins
- Autophagy in Disease and Therapy
- interferon and immune responses
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- PI3K/AKT/mTOR signaling in cancer
- Extracellular vesicles in disease
- Herpesvirus Infections and Treatments
China Medical University
2010-2019
Shenyang Center for Disease Control and Prevention
2016
First Hospital of China Medical University
2010
Growing evidence demonstrates that long noncoding RNAs (lncRNAs) are involved in the progression of various cancers including glioma. Nuclear enriched abundant transcript 1 (NEAT1), an essential lncRNA for formation nuclear body paraspeckles, was not fully explored We aimed to determine expression, roles, and functional mechanisms NEAT1 By real-time PCR, we suggested upregulated glioma tissues than noncancerous brain tissues. Knockdown reduced cell proliferation, invasion, migration. RNA...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editors. Molecular Therapy is retracting this article. After investigating concerns image duplication raised by a reader, editors identified evidence for manipulation in altered fashion Figures 3B, 6B, and 8B. reuse (and part misrepresentation) data without appropriate attribution represents severe abuse scientific publishing system....
MicroRNAs have recently emerged as key regulators of cancers. This study was therefore conducted to investigate the role miR-330 in biological behaviors human glioblastoma U87 and U251 cell lines its molecular mechanism. SH3GL2 gene identified target miR-330. MiR-330 overexpression established by transfecting precursor into cells, effects on proliferation, migration, invasion, cycle apoptosis were studied. Overexpression can enhance cellular promote migration activate also inhibit cells....
Abstract Accumulating evidence has highlighted the potential role of non-coding RNAs (ncRNAs) and upstream open-reading frames (uORFs) in biological behaviors glioblastoma. Here, we elucidated function possible molecular mechanisms effect some ncRNAs NR2C2-uORF on gliomas. Quantitative real-time PCR was conducted to profile cell expression lnc-UCA1 microRNA-627-5p (miR-627-5p) glioma tissues cells. Western blot assay used determine levels NR2C2, SPOCK1, Stable knockdown or overexpression...
Abstract Long noncoding RNAs, a subgroup of are implicated in ischemic brain injury. The expression levels Snhg8, miR-384, Hoxa13, and FAM3A were measured chronic cerebral ischemia-induced HT22 cells hippocampal tissues. role the Snhg8/miR-384/Hoxa13/FAM3A axis was evaluated ischemia models vivo vitro. In this study, we found that Snhg8 Hoxa13 downregulated, while miR-384 upregulated Overexpression silencing all inhibited apoptosis cells. Moreover, bound to sequence-dependent manner there...
Preliminary studies have shown that endothelial-monocyte-activating polypeptide-II (EMAP-II) induces autophagy and inhibits the viability of glioma cells via an unknown molecular mechanism. This study explored possible mechanisms associated with EMAP-II-induced in by regulation expression microRNA-20a (miR-20a). EMAP-II effectively inhibited viability, migration invasion human U-87 U-251 cells. also up-regulated level biomarker microtubule-associated protein 1 light chain 3(LC3)-II/I,...
The aberrantly activated antiapoptotic phospatidyl-3-inositol-kinase (PI3K)/Akt signaling induced by cisplatin limits the effectiveness of chemotherapy; inhibition this pathway may augment sensitivity tumor cells to cisplatin-induced toxicity and promote apoptosis. Cross-reacting material 197 (CRM197), nontoxic mutant diphtheria toxin, could act as an heparin-binding epidermal growth factor inhibitor has been shown have some anticancer effects, but effect CRM197 on glioma remains unclear....