A5101872496- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cardiac Imaging and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Inflammatory Bowel Disease
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- DNA Repair Mechanisms
- Acute Ischemic Stroke Management
- Ultrasound Imaging and Elastography
- Sarcoma Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Flow Measurement and Analysis
- Angiogenesis and VEGF in Cancer
- Electron Spin Resonance Studies
- Plant tissue culture and regeneration
- Radiation Therapy and Dosimetry
- Advanced Neuroimaging Techniques and Applications
Huazhong Agricultural University
2022-2024
Stanford University
2013-2023
University of South China
2021
Stanford Medicine
2018
University Radiology
2017
KU Leuven
2007-2013
Nankai University
2008
China University of Mining and Technology
2008
Significance Preclinical studies have suggested that Hedgehog (Hh) pathway inhibition reduces growth and metastasis of pancreatic ductal adenocarcinoma (PDA), but ensuing clinical trials Hh antagonists combined with cytotoxic chemotherapy not succeeded. Here, we find in three distinct genetically engineered mouse models genetic pharmacologic activity actually accelerates PDA progression. Furthermore, the acute modulation regulates balance between epithelial stromal elements, causing...
To test the hypothesis that targeting microenvironment (soil) may effectively kill cancer cells (seeds) through a small-molecular weight sequential dual-targeting theragnostic strategy, or approach.With approval from institutional animal care and use committee, 24 rats were implanted with 48 liver rhabdomyosarcomas (R1). First, vascular-disrupting agent combretastatin A4 phosphate (CA4P) was injected at dose of 10 mg/kg to cause tumor necrosis, which became secondary target. Then,...
Abstract Drought stress significantly impacts global rice production, highlighting the critical need to understand genetic basis of drought resistance in rice. Here, through a genome-wide association study, we reveal that natural variations DROUGHT RESISTANCE GENE 9 ( DRG9 ), encoding double-stranded RNA (dsRNA) binding protein, contribute resistance. Under stress, condenses into granules (SGs) liquid-liquid phase separation via crucial α-helix. recruits mRNAs OsNCED4 , key gene for...
To develop and test a molecular imaging approach that uses ultrasonography (US) clinically translatable dual-targeted (P- E-selectin) contrast agent (MBSelectin) in the quantification of inflammation at level to quantitatively correlate selectin-targeted US with fluorodeoxyglucose (FDG) combined positron emission tomography (PET) computed (CT) terms visualization different levels murine acute colitis model.Animal studies were approved by Institutional Administrative Panel on Laboratory...
Objectives: To document tumoricidal events after intravenous administration of a vascular targeting agent combretastatin A-4-phosphate (CA4P) in rodent liver tumors by using multiparametric magnetic resonance imaging (MRI) correlation with microangiography and histopathology. Materials Methods: Thirty rhabdomyosarcomas 8 to 14 mm diameter were obtained 16 days implantation lobes 15 rats. Using 1.5T magnet 4-channel wrist coil, T2-weighted (T2WI), pre- postcontrast T1-weighted (T1WI),...
We sought to assess the feasibility and reproducibility of 3-dimensional ultrasound molecular imaging (USMI) vascular endothelial growth factor receptor 2 (VEGFR2) expression in tumor angiogenesis using a clinical matrix array transducer grade VEGFR2-targeted contrast agent murine model human colon cancer.Animal studies were approved by Institutional Administrative Panel on Laboratory Animal Care. Mice with cancer xenografts (n = 33) imaged system (Philips iU22; X6-1) after intravenous...
To evaluate feasibility and reproducibility of three-dimensional (3D) dynamic contrast material-enhanced (DCE) ultrasonographic (US) imaging by using a clinical matrix array transducer to assess early antiangiogenic treatment effects in human colon cancer xenografts mice.Animal studies were approved the Institutional Administrative Panel on Laboratory Animal Care at Stanford University. Three-dimensional DCE US with two techniques (bolus destruction-replenishment) was performed (n = 38)...
Purpose: To engineer a dual human and murine Thy1-binding single-chain-antibody ligand (Thy1-scFv) for contrast microbubble-enhanced ultrasound molecular imaging of pancreatic ductal adenocarcinoma (PDAC).Experimental Design: Thy1-scFv were engineered using yeast-surface-display techniques. Binding to soluble Thy1 Thy1-expressing cells was assessed by flow cytometry. then attached gas-filled microbubbles create MBThy1-scFv binding evaluated under shear stress conditions in flow-chamber...
Our previous methodology in local sound speed estimation utilized time delays measured by the cross correlation of delayed full-synthetic aperture channel data to estimate average sound. However, focal distortions this lead biased estimates sound, which, turn, leads Here, we demonstrate bias and introduce a coherence-based estimator that eliminates is computationally much cheaper practice. Because approach medium over an equally spaced grid depth rather than time, derive refined model...
Objective. Speed of sound has previously been demonstrated to correlate with fat concentration in the liver. However, estimating speed liver noninvasively can be biased by tissue layers overlying Here, we demonstrate a noninvasive local estimator, which is based on layered media assumption, that accurately capture We validate estimator using an obese Zucker rat model non-alcoholic fatty disease and steatosis.Approach.We estimated global average 4 lean rats fed normal diet 16 high for up 8...
Abstract Purpose To determine the feasibility of in vivo diffusion‐weighted imaging (DWI) to distinguish between normal liver, viable tumor and necrosis compared postmortem DWI a rat model with vascular‐targeting treatment. Materials Methods Fifteen rats liver implantation 30 rhabdomyosarcomas were treated combretastatin A‐4‐phosphate (CA4P) at 10 mg/kg. Two days after treatment, T2‐weighted imaging, precontrast T1‐weighted postcontrast performed 1.5T scanner. Apparent diffusion coefficients...
Objective: Acute mouse models of inflammatory bowel disease (IBD) fail to mirror the chronic nature IBD in patients.We sought develop a model for assessing long-term anti-inflammatory effects with ultrasound molecular imaging (USMI) by using dual P-and E-selectin targeted microbubbles (MBSelectin).Materials and Methods: Interleukin 10 deficient (IL-10 -/-on C57BL/6 genetic background; n=55) FVB (n=16) mice were used.In IL-10 -/-mice, various experimental regimens including piroxicam,...