A5100762136- Marine Biology and Ecology Research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Parallel Computing and Optimization Techniques
- Geology and Paleoclimatology Research
- Embedded Systems Design Techniques
- Microbial Community Ecology and Physiology
- Isotope Analysis in Ecology
- Interconnection Networks and Systems
- Protist diversity and phylogeny
- Diatoms and Algae Research
- Marine and coastal ecosystems
- Real-Time Systems Scheduling
- Distributed and Parallel Computing Systems
- Paleontology and Stratigraphy of Fossils
- Marine and coastal plant biology
- Data Management and Algorithms
- Advanced Data Storage Technologies
- Technology and Data Analysis
- Blockchain Technology Applications and Security
- Advanced Database Systems and Queries
- Methane Hydrates and Related Phenomena
- Caching and Content Delivery
- Hedgehog Signaling Pathway Studies
Kongju National University
2024
Indiana University – Purdue University Indianapolis
2013-2024
University of Indianapolis
2012-2024
Hyosung Corporation (South Korea)
2024
Centre for Addiction and Mental Health
2024
Rice University
2024
Korea Advanced Institute of Science and Technology
2014-2024
Jeonbuk National University
2012-2024
Hanyang University
2017-2024
Anyang University
2017-2024
Wearable strain sensors for human motion detection are being highlighted in various fields such as medical, entertainment and sports industry.
Significance Preclinical studies have suggested that Hedgehog (Hh) pathway inhibition reduces growth and metastasis of pancreatic ductal adenocarcinoma (PDA), but ensuing clinical trials Hh antagonists combined with cytotoxic chemotherapy not succeeded. Here, we find in three distinct genetically engineered mouse models genetic pharmacologic activity actually accelerates PDA progression. Furthermore, the acute modulation regulates balance between epithelial stromal elements, causing...
Aberrant Hedgehog (Hh) pathway activation has been implicated in cancers of diverse tissues and organs, the tumor growth-inhibiting effects antagonists animal models have stimulated efforts to develop for human therapeutic purposes. These focused largely on cyclopamine derivatives or other compounds that mimic action binding antagonizing Smoothened, a membrane transductory component. We report here arsenicals, contrast, antagonize Hh by targeting Gli transcriptional effectors; short term,...
Significance Ganglion cells are the primary building block of retinal neural circuitry, but have been elusive to observe and quantify in living human eye. Here, we show a light microscopy modality that reveals not only somas these cells, also their 3D packing geometry, subtypes, spatial projection other neurons. The method provides glimpse rich tapestry neurons, glia, blood vessels compose retina, thus exposing anatomical substrate for processing visual information. Clinically,...
Abstract A new perspective suggests that a dynamic bidirectional communication system, often referred to as the microbiome-gut-brain axis, exists among gut, its microbiome, and central nervous system (CNS). This may influence brain health various brain-related diseases, especially in realms of neurodevelopmental neurodegenerative conditions. However, exact mechanism is not yet understood. Metabolites or extracellular vesicles derived from microbes gut have capacity traverse intestinal...
ABSTRACT The hedgehog family of signaling proteins is associated with a variety spatial patterning activities in insects and vertebrates. Here we show that new members this isolated from Xenopus laevis are expressed embryonically patterns suggestive roles the ectoderm, nervous system somites. Banded throughout neural plate subsequently both dermatome Cephalic anterior ectoderm endodermal structures, sonic which parallel those other species. Injection RNAs encoding hedgehogs induces ectopic...
➤ Cigarette smoking decreases bone mineral density and increases the risk of sustaining a fracture or tendon injury, with partial reversibility these risks long-term cessation smoking. for perioperative complications, nonunion delayed union fractures, infection, soft-tissue wound-healing complications. Brief preoperative may mitigate risks. Informed-consent discussions should include notification higher complications cigarette benefits temporary
SYNOPSIS. Tracer technic has proved to be an excellent tool in the study of predator‐prey relationships among foraminifera. More than fifty axenic species protists including diatoms, dinoflagellates, chlorophytes, chrysophytes, cyanophytes, bacteria and yeasts were tested as potential food for Allogromia sp (NF), A. laticollaris, Am. monia beccarii, Quinqueloculina spp, Rosalina floridana, Anomalina sp, Elphidium Spiroloculina hyalina, Globigerina bulloides , Globorotalia truncatulinoides....
Smart cities have become a trend with improved efficiency, resilience, and sustainability, providing citizens high quality of life. With the increasing demand for more participatory bottom–up governance approach, play an active role in process policy making, revolutionizing management smart cities. In example urban infrastructure maintenance, public participation is remarkable as condition closely related to their daily Although blockchain has been widely explored benefit data collection...
ABSTRACT. Protozoa may be thought of as preadapted to serve hosts for cellular endosymbionts by virtue their widespread ability take up particles endocytosis. The absence the cell wall so characteristic plants and fungi commonly large size most protozoa are additional factors favoring protozoan cells endosymbioses. conversion symbiont into a organelle (e.g. mitochondrion or chloroplast) is more complicated, especially since latter do not code all own proteins. Thus, such conversions held...
SYNOPSIS. Bacteria were required for the sustained reproduction of 4 species foraminifera in gnotobiotic culture. None algae tested, singly or combination, supported continuous bacteria‐free It is inferred that bacteria have some nutritional factor by either unavailable sufficient quantity an exclusively algal diet. Gnotobiotic clones Quinqueloculina lata, Spiroloculina hyalina, Rosalina leei , and Allogromia laticollaris established on + (usually 1 2 species). In balanced cultures neither...
Inflammation disrupts tissue architecture and function, thereby contributing to the pathogenesis of diverse diseases; signals that promote or restrict inflammation thus represent potential targets for therapeutic intervention. Here, we report genetic pharmacologic Hedgehog pathway inhibition intensifies colon (colitis) in mice. Conversely, augmentation response systemic small-molecule activation potently ameliorate colitis restrain initiation progression colitis-induced adenocarcinoma....
To test ultrasonographic (US) imaging with vascular endothelial growth factor receptor type 2 (VEGFR2)-targeted microbubble contrast material for the detection of pancreatic ductal adenocarcinoma (PDAC) in a transgenic mouse model cancer development.Experiments involving animals were approved by Institutional Administrative Panel on Laboratory Animal Care at Stanford University. Transgenic mice (n = 44; Pdx1-Cre, KRas(G12D), Ink4a(-/-)) that spontaneously develop PDAC starting 4 weeks age...
ABSTRACT. Large miliolid foraminifers of the subfamily Soritinae bear symbiotic dinoflagellates morphologically similar to species “ Symbiodinium ” complex, commonly found in corals and other marine invertebrates. Soritid are abundant coral reefs it has been proposed that they share their symbionts with dinoflagellate‐bearing reef dwellers. In order test this hypothesis, we have analysed partial large subunit ribosomal DNA sequences from obtained 28 foraminiferal specimens, compared them...
The mineralization rate of detritus derived from carbon-14 labeled eelgrass, Zostera marina, was measured in the presence and absence polychaete Nephthys incisa a mixed meiobenthic community dominated by nematodes. Oxidation rates (milligrams dry weight eelgrass per day) fresh 2 mo-old were similar (ca. 20). However, oxidation 5 around 45 with only microbenthos Nephthys, but 84 when both meiobenthos present. net incorporation (micrograms milligram worm material cultured without for fresh,...
Energetic considerations of the growth three species littoral benthic foraminifera, Allogromia laticollaris, Rosalina leei , and Spiroloculina hyalina have been made on laboratory-grown populations. Under optimum laboratory conditions A. laticollaris has greatest intrinsic rate increase (r = 2.533 org/day); S. 1.472 org/day), R. 0.272 org/day) being less fecund. The respiration rates were similar (0.5–4.5 μ1/mg body wt/hr) within temperature range (15–35 C) tested. studied are selective...