Abstract A new perspective suggests that a dynamic bidirectional communication system, often referred to as the microbiome-gut-brain axis, exists among gut, its microbiome, and central nervous system (CNS). This may influence brain health various brain-related diseases, especially in realms of neurodevelopmental neurodegenerative conditions. However, exact mechanism is not yet understood. Metabolites or extracellular vesicles derived from microbes gut have capacity traverse intestinal...

In Brief Study Design. A retrospective study. Objectives. To evaluate and compare clinical radiologic outcomes of the CHARITÉ ProDisc. Summary Background Data. There is no report comparing Methods. Among a total 61 patients who underwent disc replacement, 57 followed more than 3 years were enrolled. The was used in 33 ProDisc 24. MRI follow-up possible 52 patients. Clinical data including range motion (ROM) facet degeneration replaced segment, at adjacent level evaluated. Results. Mean...

Retrospective clinical data analysis.To compare results with radiologic of 2 fusion techniques for adult low-grade isthmic spondylolisthesis.There is clear evidence that lumbar interbody using anterior and posterior approaches provides a high rate, good sagittal alignment, outcomes. However, there are no recent studies these techniques.Between March 2004 December 2004, 48 patients underwent instrumented mini-anterior (ALIF) 46 mini-transforaminal (TLIF). The mean follow-up periods were 32.6...

The aim of this study was to evaluate the efficacy PDN prosthetic disc nucleus device for treatment chronic discogenic back pain caused by degenerative disease. Among 48 patients who underwent replacement surgery from January 2001 through May 2002, 46 were followed >6 months. mean Oswestry Disability Index score 58.9% preoperatively, and it improved 18% at 1-year follow-up. Visual Analogue Pain Scale scores a preoperative 8.5 3.1 after 1 year. Prolo also 5.2 preoperatively 7.2 Major...

Genetic and epigenetic changes (e.g., histone methylation) contribute to cancer development progression, but our understanding of whether how specific mutations affect a cancer's sensitivity demethylase (KDM) inhibitors is limited. Here, we evaluated the effects panel KDM on lung adenocarcinomas (LuAC) with various mutations. Notably, LuAC lines harboring KRAS showed hypersensitivity H3K27 inhibitor GSK-J4. Specifically, GSK-J4 treatment mutant-containing downregulated cell-cycle progression...

Purpose: To introduce easy and useful methods using 3D navigation system with skin-fixed dynamic reference frame (DRF) in anterior cervical surgery to validate its accuracy.

Solid oxide fuel cells are energy conversion devices that contribute to carbon neutrality, with the advantages of high efficiency, clean emissions production, and distributed power generation. However, operating temperature solid causes system stability material selection problems. In this study, we aimed lower a cell by reducing thickness electrolyte via sputtering. The deposition process was conducted under various pressure conditions find optimal sputtering for gas-tight YSZ thin-film...

Abstract OBJECTIVE: To present our experience of treating the central or paramedian disc herniations upper lumbar levels through a paraspinal approach. CLINICAL PRESENTATION: We four patients with intracanalicular at L1–L2 L2–L3 level. All had unilateral bilateral radicular leg pain and motor weakness. TECHNIQUE: Considering unique characteristics spine, we performed oblique approach to expose portion removed herniated effectively. Postoperatively, their symptoms were improved. There was no...

Background: The authors conducted this prospective study to analyze the amount of interfractional prostate bed motion (PBM) and quantify its components with use an endorectal balloon (ERB). Methods: A total 1,348 cone beam computed tomography images from 46 patients who underwent postprostatectomy radiotherapy were analyzed. For pilot image, electronic portal imaging, guided by skin marks was performed ensure proper positioning inflation ERB. Then, for bone matching, manual or automatic...

In this paper, a possibility of the oxygen-syngas MILD combustion was assessed using CFD analysis by applying JHC (Jet-in Hot Co-flow) system. The effect various syngas composition ratios analyzed, and heating value synthesis gas controlled ratio CO H2. Ansys Fluent, commercial code with RANS (Reynolds Averaged Navier-Stokes), modified k-ε equations EDC (Eddy Dissipation Concept) model 2D-axisymmetric computational domain used in order to analyse combustion. It confirmed that can be formed...

b-Ca3(PO4)2 (TCP) based cement combined with polyphosphate was investigated. In the bone composed of b-TCP, monocalcium monophosphate (MCPM) and calcium sulfate hemihydrate (CSH), effect amount setting agent on workability, time, temperature rise compressive strength evaluated. The polyphosphate, which selected as a growth enhancer, could be introduced without affecting properties cement. containing at calvarial defect in rabbit. After three months, covered newly formed bone, contrast case...

Abstract Background: Homozygous deletion of MTAP is one the most frequent genetic alterations in various solid tumors including glioblastoma (GBM), mesothelioma, pancreatic cancer and lung cancer. While MTAP-deleted cancers are associated with a poor prognosis, there no approved drugs for treatment patients deficiency. MAT2A has emerged as potential target selective anticancer effects cancers. However, development brain-penetrating inhibitors yet to be reported preclinical or clinical stages...

Abstract Background: Protein arginine methyltransferase 5 (PRMT5) is overexpressed in various human malignancies and induces epigenetic post-translational changes, which have a significant impact on cell growth, proliferation, apoptosis, DNA damage repair. SKL27969 potent selective brain-penetrating PRMT5 inhibitor demonstrating antitumor activity the preclinical models of glioblastoma (GBM) non-small lung cancer (NSCLC) triple-negative breast (TNBC) brain metastasis models. In this study,...

Moderate Intensity Low Oxygen Diluted (MILD) combustion has been investigated for a long time in order to minimize NOX emission still enhancing thermal efficiencies the equipment. Many researches about MILD have recently performed, but studies on of renewable fuel such as ethanol very scarce and particularly, specific information production ethanol-air not reported yet. In satisfy condition combustion, internal recirculation is known be essential entrain products gas into air jets system....