A5045752958- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Biosensors and Analytical Detection
- SARS-CoV-2 detection and testing
- Cell Image Analysis Techniques
- Electrohydrodynamics and Fluid Dynamics
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Gold and Silver Nanoparticles Synthesis and Applications
- Additive Manufacturing and 3D Printing Technologies
- Microplastics and Plastic Pollution
- Viral Infectious Diseases and Gene Expression in Insects
- Nanomaterials and Printing Technologies
- Pickering emulsions and particle stabilization
- Aerospace Engineering and Applications
- Renal and related cancers
- Molecular Biology Techniques and Applications
- Aerospace Engineering and Control Systems
- Recycling and Waste Management Techniques
- Electrowetting and Microfluidic Technologies
- Pluripotent Stem Cells Research
- Bacteriophages and microbial interactions
- Advanced Sensor and Energy Harvesting Materials
- Advanced Control and Stabilization in Aerospace Systems
- Advanced Biosensing Techniques and Applications
Sogang University
2005-2025
Kidney organoids derived from the human pluripotent stem cells (hPSCs) recapitulating kidney are attractive tool for regeneration, disease modeling, and drug screening. However, cultured by static conditions have limited vascular networks immature nephron-like structures unlike kidney. Here, we developed a organoid-on-a-chip system providing fluidic flow mimicking shear stress with optimized extracellular matrix (ECM) conditions. We demonstrated that in our microfluidic showed more matured...
Abstract Despite their simplicity, monolayer cell cultures are not able to accurately predict drug behavior in vivo due inability mimic cell-cell and cell-matrix interactions. In contrast, spheroids reproduce these interactions thus would be a viable tool for testing behavior. However, the generation of homogenous reproducible on large scale is labor intensive slow process compared cultures. Here, we present droplet-based microfluidic device automated, large-scale uniform manner. Using...
Multiplexed droplet digital recombinase polymerase amplification (MddRPA) for detection of pandemic diseases.
Abstract Core-shell nanoparticles are promising candidates for theranostic drugs, as they combine different intrinsic properties with a small size and large surface area. However, their controlled synthesis, or the screening optimization of synthesis conditions often difficult labor intensive. Through precise control over mass heat transfer, automatization possibilities, microfluidic devices could be solution to this problem in lab scale synthesis. Here, we demonstrate microfluidic,...
Abstract In molecular diagnostics, the digital polymerase chain reaction (dPCR) has been considered a promising point-of-care testing (POCT) method for rapid and accurate analysis of respiratory infections. To improve its practical applicability, it is necessary to develop mass-producible reproducible dPCR system nucleic acid partitioning; additionally, must provide customized portable analysis. this study, we report an advanced mass-production fabrication microwell array-based chips...
A miniaturized polymerase chain reaction (PCR) system is not only important for medical applications in remote areas of developing countries, but also testing at ports entry during global epidemics, such as the current outbreak coronavirus. Although there a large number PCR sensor systems available this purpose, still lack portable digital (dPCR) heating systems. Here, we first demonstrated plasmonic heating-based dPCR system. The device has total dimensions 9.7 × 5.6 4.1 cm and power...
A three-dimensional (3D) tumor spheroid model plays a critical role in mimicking microenvironments vivo. However, the conventional culture methods lack ability to manipulate 3D spheroids homogeneous manner. To address this limitation, we developed microfluidic-based droplet system for drug screening applications. We used tree-shaped gradient generator control cell density and encapsulate cells within uniform-sized droplets generate gradient-sized spheroid. Using system, demonstrated...
Nanoparticles have gained large interest in a number of different fields due to their unique properties. In medical applications, for example, magnetic nanoparticles can be used targeting, imaging, magnetically induced thermotherapy, or any combination the three. However, it is still challenge obtain narrowly dispersed, reproducible particles through typical lab-scale synthesis when researching these materials. Here, we present droplet capillary reactor that iron oxide nanoparticles....
IoT-integrated multiplexed digital PCR system for detection of infectious diseases.
The droplet-generating microfluidics has become an important technique for a variety of applications ranging from single cell analysis to nanoparticle synthesis. Although there are large number methods generating and experimenting with droplets on microfluidic devices, the dispensing these devices is challenge due aggregation merging at interface devices. Here, we present dual-nozzle device generation uniform-sized droplets. first nozzle used droplets, while second can accelerate increase...
We developed copper sulfide (CuS)/reduced graphene oxide (rGO)-poly (ethylene glycol) (PEG) nanocomposites for photothermal bonding of a polymethyl methacrylate (PMMA)-based plastic lab-on-a-chip. The noncontact PMMA-based labs-on-chip plays an important role in improving the stability and adhesion at high-temperature as well minimizing solution leakage from microchannels when connecting two microfluidic devices. CuS/rGO-PEG were used to bond lab-on-a-chip short time with high effect by...
Polymerase chain reaction has gained attention since the outbreak of novel coronavirus in 2019. Due to its high specificity and capability for early detection, it is considered a standard method diagnosis infectious diseases. However, conventional thermocyclers used nucleic acid amplification are not suitable point-of-care testing applications, as they require expensive instruments, high-power consumption, long turnaround time. To suppress widespread pandemic, there an urgent need...