A5100405294- Urinary Bladder and Prostate Research
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Head and Neck Cancer Studies
- Renal Diseases and Glomerulopathies
- Pelvic floor disorders treatments
- Advanced Neuroimaging Techniques and Applications
- Birth, Development, and Health
- Connexins and lens biology
- Autism Spectrum Disorder Research
- Barrier Structure and Function Studies
- Cancer, Hypoxia, and Metabolism
- Chronic Kidney Disease and Diabetes
- Heart Rate Variability and Autonomic Control
- Pediatric Urology and Nephrology Studies
- Genetics and Neurodevelopmental Disorders
- Obstructive Sleep Apnea Research
- Natural Compounds in Disease Treatment
- Physical Activity and Health
- Family and Disability Support Research
- Body Composition Measurement Techniques
- Cell Adhesion Molecules Research
- Natural product bioactivities and synthesis
- Neuroscience of respiration and sleep
Kunming Medical University
2025
Ruijin Hospital
2013-2024
Shanghai Jiao Tong University
2015-2024
Shanghai University
2022-2024
Shanghai Children's Medical Center
2012-2024
Peking University
2011-2024
Shanghai University of Sport
2024
Shanghai University of Medicine and Health Sciences
2024
National Health and Family Planning Commission
2024
Shanxi Academy of Medical Sciences
2024
Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several human malignancies, including hepatocellular carcinoma (HCC). However, the role of LOXL4 HCC progression remains largely unclear. In this study, we investigated clinical significance and biological involvement HCC. expression was measured tissues cell lines. Overexpression, shRNA-mediated knockdown, recombinant (rhLOXL4), deletion mutants were applied study function Exosomes derived from lines assessed for ability...
A new human colon cancer cell line (LIM1215) has been derived from a tumor arising in member of family known to have high incidence colorectal cancer. The is comprised small pleomorphic cells that clone liquid medium and form tumors immunosuppressed mice. Ultrastructurally, the are capable differentiation, with multiple microvilli resembling goblet being present one culture. pseudodiploid contain 13p+ marker chromosome.
Abstract Patients with acquired chronic bilateral vestibular loss were recently found to have a significant impairment in spatial memory and navigation when tested virtual Morris water task. These deficits associated selective atrophy of the hippocampus, which suggests that also rely on input. In present study 16 patients unilateral deafferentation due acoustic neurinoma examined 5‐ 13‐yrs post‐surgery. Volumetry hippocampus was performed age‐ sex‐matched healthy controls by manually tracing...
Objective: The aim of this study was to test the efficacy and appropriateness World Health Organization's Care for Development (CFD) counseling materials, which form part Integrated Management Childhood Illness (IMCI) strategy. CFD materials are based on Mother's Card, contained age-specific messages how caregivers can better play communicate with a child. Method: We enrolled 100 families child younger than 2 years age from seven randomly selected villages in an impoverished rural county...
Focal segmental glomerulosclerosis (FSGS) is a histologically identifiable glomerular injury often leading to proteinuria and renal failure. To identify its causal genes, whole-exome sequencing Sanger were performed on large Chinese cohort that comprised 40 FSGS families, 50 sporadic patients, 9 independent autosomal recessive Alport's syndrome (ARAS) 190 ethnically matched healthy controls. Patients with extrarenal manifestations, indicating systemic diseases or other known hereditary...
Abstract Sepsis remains the leading cause of death in critically ill patients, despite modern advances critical care. Intestinal barrier dysfunction may lead to secondary bacterial translocation and development multiple organ syndrome during sepsis. Cyclooxygenase (COX)-2 is highly upregulated intestine sepsis, we hypothesized that it be maintenance intestinal epithelial function peritonitis-induced polymicrobial COX-2−/− COX-2+/+ BALB/c mice underwent cecal ligation puncture (CLP) or sham...
Previous research has demonstrated that there are specific white matter abnormalities in patients with attention deficit/hyperactivity disorder (ADHD). However, the results of these studies not consistent and one most important factors affects inconsistency previous maybe ADHD subtype. Different subtypes may have some overlapping microstructural damage, but they also unique abnormalities. The objective this study was to investigate associated two ADHD: combined (ADHD-C) inattentive (ADHD-I)....
Abstract Pancreatic ductal adenocarcinoma (PDAC) tumours exhibit a high level of heterogeneity which is associated with hypoxia and strong resistance to chemotherapy. The RNA splicing protein polypyrimidine tract‐binding 3 (PTBP3) regulates hypoxic gene expression by selectively binding hypoxia‐regulated transcripts. We have investigated the role PTBP3 in tumour development chemotherapeutic human PDAC tissues pancreatic cancer cells. In addition, we determined sensitivity cells gemcitabine...
One of the key challenges in achieving practical lithium-air battery is poor moisture tolerance lithium metal anode. Herein, guided by theoretical modeling, an effective tactic for realizing water-resistant Li anode implementing a wax-assisted transfer protocol reported to passivate surface with inert high-quality chemical vapor deposition (CVD) graphene layer. This electrically conductive and mechanically robust coating enables serving as artificial solid/electrolyte interphase (SEI),...
Abstract Primary monosymptomatic nocturnal enuresis (PMNE) is a common disorder in school‐aged children. However, little known about resting‐state neural function individuals with PMNE. In this work, functional magnetic resonance imaging (fMRI) was used to investigate changes spontaneous brain activity children We analyzed fMRI data using statistical parametric mapping (SPM) and analysis toolkit (REST). Regional homogeneity (ReHo) amplitude of low‐frequency fluctuation (ALFF) values were...
<b><i>Background:</i></b> Gitelman syndrome (GS) is an autosomal recessive disease of renal tubulopathy, primarily characterized by hypokalemic metabolic alkalosis with significant hypomagnesemia, low urinary calcium, secondary aldosteronism and normal blood pressure. Both hypokalemia hypomagnesemia were reported to cause impaired glucose tolerance and/or insulin resistance, but it unclear whether resistance are common in GS patients....
Background Primary monosymptomatic nocturnal enuresis (PMNE) is a common disorder in school-aged children. Previous studies have suggested that developmental delay might play role the pathology of children with PMNE. However, microstructural abnormalities brains these not been thoroughly investigated. Methodology/Principal Findings In this work, we evaluated structural changes PMNE using diffusion tensor imaging (DTI). Two groups consisting 26 and healthy controls were scanned magnetic...
Abstract Nocturnal enuresis is a common developmental disorder in children, and primary nocturnal (PNE) the dominant subtype. The main purpose of this study was to investigate brain functional abnormalities specifically related motor response inhibition children with PNE using fMRI combination Go/NoGo task. Twenty‐two 22 healthy group‐matched for age sex, took part experiment. Although no significant between‐group differences task performance accuracy were observed, patients showed...
Abstract: Insufficient early vascularization in biological meshes, resulting limited host tissue incorporation, is thought to be the primary cause for failure of abdominal wall defect repair after implantation. The sustained release exogenous angiogenic factors from a biocompatible nanomaterial might way overcome this limitation. In study reported here, multiwalled carbon nanotubes (MWNT) were functionalized by plasma polymerization deliver vascular endothelial growth factor 165 (VEGF )....
Sepsis with thrombocytopenia is highly prevalent in critically ill intensive care unit (ICU) patients and associated adverse outcomes. Platelet transfusion the primary treatment of choice. However, evidence for beneficial effects platelet sepsis scarce low quality. This study aimed to evaluate association between mortality among ICU thrombocytopenia.Using Medical Information Mart Intensive Care III database (v. 1.4), outcomes counts ≤ 150,000/μL were compared those who did not receive...
Background/Aims: Non-small cell lung carcinoma (NSCLC) is the most common type of cancer and cause cancer-related deaths. The molecular mechanisms that are involved in NSCLC development currently not well understood. Accumulating evidence shows histone demethylases play important roles regulation pathological developmental processes many diseases, including various types cancers. Methods: Mitochondrial membrane potential assays, migration invasion caspase-3 caspase-9 activity assays western...