A5100617849- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
- Tendon Structure and Treatment
- Epigenetics and DNA Methylation
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Reconstructive Surgery and Microvascular Techniques
- Bone health and treatments
- Hepatitis B Virus Studies
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Sarcoma Diagnosis and Treatment
- Wound Healing and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Proteoglycans and glycosaminoglycans research
- Bone Tumor Diagnosis and Treatments
- Orthopedic Surgery and Rehabilitation
- Reproductive Biology and Fertility
- Cancer-related gene regulation
- Renal Diseases and Glomerulopathies
- Connective tissue disorders research
- Pituitary Gland Disorders and Treatments
- TGF-β signaling in diseases
Center for Life Sciences
2023-2025
Beijing VDJBio (China)
2025
Tsinghua University
2023-2025
Molecular Oncology (United States)
2014-2025
State Key Laboratory of Molecular Oncology
2025
Shanxi Medical University
2025
Nanjing Medical University
2021-2024
Jiangsu Province Hospital
2021
Jilin Medical University
2020
Yantai University
2020
Abstract Chitosan has been shown to be a promising scaffold for various applications in tissue engineering. In this study, chitosan‐gelatin complex was fabricated as by freezing and lyophilizing technique. Chitosan's structure characteristics are similar those of glycosaminoglycan (GAG) its analogs, possesses biological activities, whereas gelatin can serve substrate cell adhesion, differentiation, proliferation. With the use autologous chondrocytes isolated from pig's auricular cartilage...
Abstract In mammals, oocytes are arrested at the diplotene stage of meiosis I until pre-ovulatory luteinizing hormone (LH) surge triggers meiotic resumption through signals in follicular granulosa cells. this study, we show that estradiol (E2)-estrogen receptors (ERs) system cells has a dominant role controlling oocyte mammals. We found expression ERs was controlled by gonadotropins under physiological conditions. E2-ERs functional maintaining arrest regulating natriuretic peptide C and...
Ectomesenchymal chondromyxoid tumor (ECT) is a rare benign intraoral that almost exclusively presents as small mass on the anterior dorsal tongue. Recently, ras-responsive element-binding protein 1::myocardin-related transcription factor B (RREB1::MRTFB; previously known MKL2) fusion gene has been identified in 90% of ECTs, all localized to tongue, highlighting its genetic distinctiveness. Herein, we report mesenchymal involving plantar fascia left foot young woman, harboring RREB1::MRTFB...
Abstract Molecular interplay between host epigenetic factors and viral proteins constitutes an intriguing mechanism for sustaining hepatitis B virus (HBV) life cycle its chronic infection. HBV encodes a regulatory protein, HBx, which activates transcription replication of genome organized as covalently closed circular (ccc) DNA minichromosome. Here we illustrate how HBx accomplishes task by hijacking Spindlin1, reader comprising three consecutive Tudor domains. Our biochemical structural...
Cartilage tissue engineering holds great promise for treating cartilaginous pathologies including degenerative disorders and traumatic injuries. Effective cartilage regeneration requires an optimal combination of biomaterial scaffolds, chondrogenic seed cells, biofactors. Obtaining sufficient chondrocytes remains a major challenge due to the limited proliferative capability primary chondrocytes. Here we investigate if reversibly immortalized mouse articular (iMACs) acquire long-term while...
Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes. Autologous stem cell-based therapies and transgene-enhanced cartilage tissue engineering may open new avenues treatment injuries. Bone morphogenetic protein 2 (BMP2) induces chondrogenesis mesenchymal cells (MSCs) can thus be explored as a potential therapeutic agent defect repair. However, BMP2 also robust...
This study investigated the expression and function of microRNA-494 in intervertebral disc degeneration (IDD).MicroRNA-494 was upregulated during IDD progression; its overexpression increased ECM catabolic factors such as matrix metalloproteinase A disintegrin with thrombospondin motif NP cells while decreasing that anabolic genes type II collagen aggrecan; it also induced apoptosis cells, determined by flow cytometry. These effects were reversed inhibitor treatment. SOX9 identified a target...
Abstract Spinal cord injury (SCI) leads to acute tissue damage that disrupts the microenvironmental homeostasis of spinal cord, inhibiting cell survival and function, thereby undermining treatment efficacy. Traditional stem therapies have limited success in SCI, due difficulties maintaining inducing sustained differentiation into neural lineages. A new solution may arise from controlling fate cells by creating an appropriate mechanical microenvironment. In this study, response complex...
Abstract Chronic atrophic gastritis (CAG) is regarded as a transitional stage in the progression from to gastric tumors. Although preserved egg white (PEW) recognized for its anti-inflammatory properties, precise impact and mechanisms treating inflammation are not fully understood. This study employed an integrative approach, combining network pharmacology with experimental validation, elucidate therapeutic effects of PEW on CAG underlying mechanisms. Through pharmacology, potential targets...
Podocyte apoptosis contributes to the pathogenesis of diabetic nephropathy (DN). However, mechanisms that mediate hyperglycemia-induced podocyte remain poorly understood. Recent findings indicate disruption cytoskeleton is related apoptosis. In present study, we investigated involvement nestin, an important cytoskeleton-associated class VI intermediate filament (IF) protein, in high glucose (HG)-induced Our data showed HG decreased expression level either mRNA or a time-dependent manner...
Abstract: Insufficient early vascularization in biological meshes, resulting limited host tissue incorporation, is thought to be the primary cause for failure of abdominal wall defect repair after implantation. The sustained release exogenous angiogenic factors from a biocompatible nanomaterial might way overcome this limitation. In study reported here, multiwalled carbon nanotubes (MWNT) were functionalized by plasma polymerization deliver vascular endothelial growth factor 165 (VEGF )....
Tendinopathy leads to low-grade tissue inflammation and chronic damage, which progresses due pathological imbalance in angiogenesis. Reducing early vascularization may be a new approach helping regenerate tendon tissue. Conventional stem cell therapy engineering scaffolds have not been highly effective at treating tendinopathy. In this study, engineered cells (TSCs) generated using human umbilical cord mesenchymal (hUC-MSCs) were combined with microcarrier limit excessive By preventing VEGF...
Tendons are subjected to high strength dynamic mechanical forces in vivo. Mechanical is an essential requirement for tendon scaffold materials. A composite was used this study provide strength, which composed of inter part nonwoven polyglycolic acid (PGA) fibers and outer the net knitted with PGA polylactic (PLA) a ratio 4:2. This compared three different approaches vivo engineering, that is, cell-free allogeneic autologous cell seeded scaffolds, using rabbit Achilles repair model. Dermal...
Irritable bowel syndrome (IBS) is a chronic, stress-related, functional gastrointestinal disorder characterized by abdominal discomfort and altered habits; the manipulation of microbiota emerging as promising therapeutic option for IBS. Cynanchum thesioides (CT) an herb traditional Mongolian medicine that has been employed in treating pain diarrhea hundreds years. Phytochemical studies this plant showed presence various flavonoids with antibacterial anti-inflammatory activities. We...
Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is associated with chondrogenesis, neurogenesis, immune response, biological rhythm, lipogenesis, cell differentiation and carcinogenesis. However, there little information about its contribution to osteoblast osteogenesis. In the present study, we report that DEC1 expression increases along degree of mineralization, which parallells increase osteogenesis induction time in SaoS-2 cells. Dexamethasone (DEX) decreases capacity such as...
Objective To explore the feasibility of in vivo chondrogenesis bone marrow stromal cells (BMSCs) co-cultured with chondrocytes on biodegradable scaffold. Methods Porcine BMSCs were isolated, expanded and labeled enhanced green fluorescent protein (EGFP), then mixed articular isolated from porcine knee joint at ratio 1:1. The seeded onto polyglycolic acid (PGA) scaffold ultimate concentration 5.0 x 10(7)/ml (co-culture group). Pure same respectively as positive control group negative group....