A5100554550- Multiple Myeloma Research and Treatments
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Spine and Intervertebral Disc Pathology
- Circular RNAs in diseases
- Periodontal Regeneration and Treatments
- Peptidase Inhibition and Analysis
- High-Temperature Coating Behaviors
- Bone Metabolism and Diseases
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Sirtuins and Resveratrol in Medicine
- High Entropy Alloys Studies
- Silk-based biomaterials and applications
- TGF-β signaling in diseases
- Agriculture, Soil, Plant Science
- Protein Degradation and Inhibitors
- Cancer Treatment and Pharmacology
- COVID-19 and Mental Health
- Pregnancy-related medical research
- Advanced Computational Techniques and Applications
- Additive Manufacturing Materials and Processes
- Musculoskeletal pain and rehabilitation
- Evaluation Methods in Various Fields
Shanghai Zhabei District Shibei Hospital
2020-2025
Chongqing Medical University
2015-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2024
Yangtze River Pharmaceutical Group (China)
2024
Xinqiao Hospital
2023
Army Medical University
2023
Jiang Xi Institute for Drug Control
2023
Guizhou Institute of Technology
2023
Kunming Children's Hospital
2021
Amos Enterprise (China)
2020
Bone morphogenetic protein 2 (BMP2) is one of the key chondrogenic growth factors involved in cartilage regeneration. However, it also exhibits osteogenic abilities and triggers endochondral ossification. Effective chondrogenesis inhibition BMP2-induced osteogenesis ossification can be achieved by directing mesenchymal stem cells (MSCs) towards chondrocyte lineage with chodrogenic factors, such as Sox9. Here we investigated effects Sox9 on differentiation MSCs. We found exogenous...
Background/Aims: Joint cartilage defects are difficult to treat due the limited self-repair capacities of cartilage. Cartilage tissue engineering based on stem cells and gene enhancement is a potential alternative for repair. Bone morphogenetic protein 2 (BMP2) has been shown induce chondrogenic differentiation in mesenchymal (MSCs); however, maintaining phenotypes MSCs during repair since occurs along endochondral ossification pathway. In this study, hypoxia inducible factor, or (HIF)-1α,...
Abstract Cartilage end plates (CEP) degeneration plays an integral role in intervertebral disc (IVD) resulting from nutrient diffusion disorders. Although cell senescence oxidative stress is known to contribute degeneration, no studies concerning the of CEP have been conducted. SIRT1 a longevity gene that pivotal many cellular functions, including senescence. Therefore, aim this study was investigate whether more prominent human degenerative and SIRT1-regulated cells IVD as well identify...
This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate potential 10 specific circRNAs as diagnostic prognostic biomarkers in multiple myeloma (MM).In exploration stage (stage I), profiles were detected by microarray bone marrow plasma cells from 4 MM patients healthy controls (HCs), bioinformatic analyses performed. In validation II), top upregulated downregulated identified I 60 30 HCs for validation; values these analyzed.In I, 122...
Lipid metabolism disorders are associated with degeneration of multiple tissues and organs, but the mechanism crosstalk between lipid disorder intervertebral disc (IDD) has not been fully elucidated. In this study we aim to investigate regulatory abnormal signal on endplate chondrocyte (EPC) senescence calcification.
Objective Thrombotic events (TEs) are common and severe complications of newly diagnosed multiple myeloma (NDMM). However, the impact thrombosis on survival patients remains controversial. The aim our study was to identify independent high-risk factors for as well explore association between incidence TEs in with NDMM.
Cartilage injuries caused by arthritis or trauma pose formidable challenges for effective clinical management due to the limited intrinsic proliferative capability of chondrocytes. Autologous stem cell-based therapies and transgene-enhanced cartilage tissue engineering may open new avenues treatment injuries. Bone morphogenetic protein 2 (BMP2) induces chondrogenesis mesenchymal cells (MSCs) can thus be explored as a potential therapeutic agent defect repair. However, BMP2 also robust...
Resveratrol is known to improve functional recovery after spinal cord injury, but the exact mechanism involved yet unclear. The aim of this study was clarify whether resveratrol can exert neuroprotective effects via activating neuronal autophagic flux, in view underlying role flux mediated by on apoptosis and identify liver kinase B1(LKB1)/adenosine monophosphate-activated protein (AMPK)/mammalian target rapamycin (mTOR)/ p70 ribosomal S6 (p70s6k) signal pathway resveratrol. results obtained...
// Zheng Lu 1 , Zhou Nian Zhang Jingjing Luo Tao and Li Quan Department of Gynaecology, The First Affiliated Hospital Zunyi Medical College, Zunyi, Guizhou 563000, P.R. China Correspondence to: Quan, email: liquan9766@sina.com Keywords: miR-424; E2F6; endometrial carcinoma Received: August 23, 2017 Accepted: October 28, Published: December 13, ABSTRACT Our previous study explored the roles microRNA-424 (miR-424) in development (EC) analyzed miR-424/E2F7 axis EC cell growth. In this study, we...
Articular cartilage defects are common in the clinic but difficult to treat.Exploring chondrogenic molecular mechanisms of mesenchymal stem cells (MSCs) is great theoretical interest and industrial significance.Bone morphogenetic protein 2 (BMP2) a key factor that induces differentiation can induce cell differentiation.However, oxidative stress microenvironment during injury degeneration inhibits regeneration homeostasis.Silent mating type information regulator homolog-1 (SIRT1) an important...
Subchondral sclerosis is considered the main characteristic of advanced osteoarthritis, in which bone remodeling mediated by transforming growth factor β (TGFβ) signaling plays an indispensable role metabolism. Osteocytes have been identified as pivotal regulators metabolism, due to their mechanosensing and endocrine function. Therefore, aim present study was investigate association between osteocyte TGFβ signal subchondral sclerosis. Knee tibia plateau samples were collected from...
Background This Mendelian randomization (MR) study aimed to explore the causal relationship between polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD). Methods We conducted a two-sample MR analysis figure out if there is any effect of PUFAs on BMD through summary data from genome-wide association (GWAS). Relationships were evaluated inverse variance weighted (IVW), MR-Egger, median, maximum likelihood methods. The Pleiotropy RESidual Sum Outlier (MR-PRESSO) test was performed...
Bone morphogenetic protein 9 (BMP9) is a potent inducer of osteogenic differentiation mesenchymal stem cells. The Wnt antagonist Dickkopf-1 (Dkk1) involved in skeletal development and bone remodeling. Here, we investigated the role Dkk1 BMP9-induced MSCs. We found that overexpression BMP9 induced expression dose-dependent manner, which was reduced by P38 inhibitor SB203580 but not ERK PD98059. Moreover, dramatically decreased only alkaline phosphatase (ALP) activity also osteocalcin (OCN)...
Objective The purpose of this study was to investigate the association between serum polyunsaturated fatty acids (PUFAs) and bone mineral density (BMD). Methods We performed a cross-sectional based on data from National Health Nutrition Examination Survey (NHANES) 2011-2014. weighted multiple linear regression model utilized determine PUFAs BMD. Further smoothed curve fitting threshold effect analysis were conducted. Finally, we subgroup analysis. Results In total, 1979 participants aged...
Our previous study observed that circular RNA protein tyrosine kinase 2 (circ-PTK2) was upregulated and correlated with worse clinical features unfavorable prognosis in multiple myeloma (MM) patients. Thus, this aimed to further characterize the regulatory function of circ-PTK2 on cell malignant activities its target microRNA-638 (miR-638) as well downstream MEK/ERK, WNT/β-catenin signaling pathways MM. The effect MM proliferation, apoptosis, migration, invasion potential miRNAs assessed by...
Wilms' tumor (WT) is a major type of kidney cancer in children; however, the therapeutic measures for control metastasis, recurrence and death this remain unsatisfactory. The present study aimed to verify expression T‑cell factor 3 (TCF3) WT, explore its role regulating viability, migration apoptosis cells. Tumor tissues were collected from 10 patients with adjacent as normal controls. levels TCF3 detected WT by reverse transcription‑quantitative PCR (RT‑qPCR), western blotting...
Abstract Enhancer RNAs (eRNAs) are a subclass of non-coding that generated during the transcription enhancer regions and play an important role in tumourigenesis. In this study, we focused on crucial eRNAs participate immune responses invasive breast cancer (IBC). We first used The Cancer Genome Atlas Human RNA to screen for tissue-specific their target genes. Through Pearson correlation analysis with genes, eRNA WAKMAR2 was identified as key candidate involved IBC. Our further research...
The Second Revision of the International Staging System (R2-ISS) was recently introduced to improve risk stratification over that provided by extensively applied standard revised (R-ISS). In addition variables included in R-ISS, R2-ISS incorporates chromosome 1q gain/amplification and divides patients into 4 groups with different survival outcomes, better stratifying within R-ISS intermediate-risk. new model developed based on a great quantity data from participating uniform clinical trials...
Gain or amplification 1q21 (1q21+) is one of the most common recurrent cytogenetic abnormalities in multiple myeloma (MM). Our aim was to explore presentation and outcomes patients with MM harboring + .We retrospectively analyzed clinical features survival 474 consecutive receiving immunomodulatory drugs proteasome inhibitor-based regimens as first-line therapies.1q21 detected 249 (52.5%) patients. Patients had a higher proportion subtypes IgA, IgD, λ-light chain than non-1q21 . associated...
The Nicotinamide phosphoribosyltransferase (Nampt)-NAD-Sirt1 pathway modulates processes involved in the pathogenesis of multiple diseases by influencing inflammation. This study aimed to explore effect Nampt osteogenic differentiation and inflammatory response osteoblastic MC3T3-E1 cells. We developed an vitro model lipopolysaccharide (LPS)-induced inflammation showed that Sirt1 were significantly upregulated LPS-treated LPS induced secretion proinflammatory cytokine interleukin-6 (IL-6)...