A5025528191- Pancreatic function and diabetes
- Renal Diseases and Glomerulopathies
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Diabetes and associated disorders
- Pulmonary Hypertension Research and Treatments
- Xenotransplantation and immune response
- Chronic Kidney Disease and Diabetes
- Immune Cell Function and Interaction
- Nitric Oxide and Endothelin Effects
- Diabetes Management and Research
- Hepatitis B Virus Studies
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- Complement system in diseases
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Natural Compounds in Disease Treatment
- Hormonal Regulation and Hypertension
- Cannabis and Cannabinoid Research
- Apelin-related biomedical research
Shaanxi Provincial People's Hospital
2025
Shanxi Medical University
2025
Harbin Medical University
2012-2024
University of Missouri
2023-2024
Second Affiliated Hospital of Harbin Medical University
2011-2024
Children's Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Zhengzhou Children's Hospital
2024
Children's Mercy Hospital
2017-2024
Zhengzhou University
2024
Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 fusion-positive uterine sarcomas that should be distinguished from leiomyosarcoma and undifferentiated sarcoma. rearrangements were detected by fluorescence situ hybridization (FISH) and/or targeted RNA or DNA sequencing spindle cell morphology. Because of histologic overlap leiomyosarcoma, TrkA pan-Trk immunohistochemistry was performed 97...
With the advent of next-generation sequencing, an increasing number novel gene fusions and other abnormalities have emerged recently in spectrum EWSR1 -negative small blue round cell tumors (SBRCTs). In this regard, a subset SBRCTs harboring either BCOR ( BCOR-CCNB3 , BCOR-MAML3 ), internal tandem duplications (ITD), or YWHAE-NUTM2B share transcriptional signature including high mRNA expression, as well similar histologic features. Furthermore, such clear sarcoma kidney (CCSK) primitive...
Small blue round cell tumors (SBRCTs) are a heterogenous group of that difficult to diagnose because overlapping morphologic, immunohistochemical, and clinical features. About two-thirds EWSR1-negative SBRCTs associated with CIC-DUX4-related fusions, whereas another small subset shows BCOR-CCNB3 X-chromosomal paracentric inversion. Applying paired-end RNA sequencing an SBRCT index case 44-year-old man, we identified novel BCOR-MAML3 chimeric fusion, which was validated by reverse...
Recent evidence shows that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon (IFN) genes (STING) signaling is essential for antitumor immunity by inducing the production type I IFN and thus activating both innate adaptive based on gene knockout mouse models. However, extensive detection expression cGAS/STING in human cancer mining roles this pathway have not been performed until now. In study, we revealed four key molecules (cGAS, STING, TANK binding kinase 1 [TBK1], regulatory factor...
The multidrug resistance (MDR) of cancer cells is a major obstacle in chemotherapy and very few strategies are available to overcome it. Here, new strategy developed codeliver π–π stacked dual anticancer drug combination with an actively targeted, pH‐ reduction‐sensitive polymer micellar platform for combating tumor metastasis. In contrast other methods, two traditional chemotherapeutics, doxorubicin (DOX) 10‐hydroxycamptothecin complex aromatic conjugated structures, integrated into one...
Abstract Background Our previous studies demonstrated that the administration of crude Polysaccharide from Panax notoginseng (CPPN) can effectively prolong lifespan tumor-bearing mice via boosting host immune system as well weak cytotoxicity against hepatocellular carcinoma (HCC). In present study, Neutral (NPPN) were further purified polysaccharide isolated panax . The effects NPPN on function and hematopoietic with low immunity myelosuppression induced by cyclophosphamide (CTX)...
Abstract 15‐Hydroxyeicosatetraenoic acid (15‐HETE), a product of arachidonic (AA) catalyzed by 15‐lipoxygenase (15‐LO), plays an essential role in hypoxic pulmonary arterial hypertension. We have previously shown that 15‐HETE inhibits apoptosis artery smooth muscle cells (PASMCs). To test the hypothesis such effect is attributable to hypoxia‐induced vascular remodeling (PVR), we performed these studies. found subtle thickening proximal media/adventitia arteries (PA) rats had been exposed...
The early diagnosis and accurate prognosis prediction of esophageal cancer is an essential part improving survival. However, these diseases lack effective specific markers. A total 1,744 samples HumanMethylation450 data were integrated to identify validate methylation markers for adenocarcinoma (EAC) squamous cell carcinoma (ESCC) as well Barrett's esophagus (BE) using Cancer Genome Atlas the Gene Expression Omnibus. diagnostic prognostic classifiers constructed by moderated t-statistics...
Immunoglobulin A nephropathy (IgAN) is the most frequent form of glomerulonephritis, which characterized by glomerular proliferation and renal inflammation. Icariin a flavonoid from Chinese herb Epimedium, its anti-inflammatory effect has been reported. This study aimed to investigate effects icariin on damage in IgAN rats mechanisms behind these effects. model was established Sprague-Dawley oral intravenous immunization with bovine gamma-globulin for 12 weeks, were treated 18 weeks. At end...
Abstract Long non-coding RNAs (lncRNAs) could modulate expression of immune checkpoints (ICPs) by cooperating with immunity genes in tumor immunization. However, precise functions and potential for predicting ICP inhibitors (ICI) response have been described only a few lncRNAs. Here we present an integrated framework that leverages network-based analyses Bayesian network inference to identify the regulated relationships including lncRNA, as ICP-related LncRNAs mediated Core Regulatory...
Abstract Most pancreatic islets are destroyed immediately after intraportal transplantation by an instant blood-mediated inflammatory reaction (IBMIR) generated through activation of coagulation, complement, and proinflammatory pathways. Thus, effective mitigation IBMIR may be contingent on the combined use agents targeting these pathways for modulation. CD47 thrombomodulin (TM) two molecules with distinct functions in regulating coagulation responses. We previously reported that islet...
Ovarian cancer is often accompanied by the production of ascites, and patients with repeated ascites are associated chemotherapy resistance. The previous study confirmed that ovarian who developed after had elevated autophagy levels in precipitated cells, which was positively correlated MDR1 expression blood patients.In order to explore correlation between chemoresistant, we searched TCGA GEO database analyze LC3B MDR1, identified targeting miRNA LC3B. It verified dual luciferase miR-204 can...
To study the expression of MRPL13 in breast cancer tissues using TCGA database, analyze correlation between and clinicopathological characteristics patients, explore role development (BC). The BC mRNA data clinical information were downloaded from database. parameters was analyzed. Cox regression multivariate analysis used to factors affecting prognosis patients. UALCAN database level its relationship with pathological factors. GSEA method predict possible regulatory pathways MRPL13. Immune...
Abstract Background To investigate the effect of HBV on proliferative ability host cells and explore potential mechanism. Methods MTT, colony formation assay tumourigenicity in nude mice were performed to capability cells. In order mechanism, cell cycle apoptosis analysed. The genes controlling G1/S phase transition detected by immunohistochemistry, westernblot RT-PCR. Results HepG2.2.15 showed decreased proliferation compared HepG2 G1 arrest was main cause but not associated with apoptosis....
Persistent human papillomavirus HPV infection is a necessary but insufficient condition for cervical cancer. Microorganisms are crucial environmental factors in cancers susceptibility and progression, recently attracting considerable attention. This study aimed to determine the status relationship between high-risk (HR-HPV) lower genital tract infectious pathogens cancer its precursors. From retrospective prospective cohort analysis, Escherichia coli (E. coli) dominated isolated from...
Glomerular fibrosis has been shown to be closely related the progression and prognosis of IgA nephropathy (IgAN). However, mechanism underlying IgAN glomerular remains unclear. Recently, our study showed that plasma gelsolin (pGSN) was decreased in serum an mouse model pGSN deposition found glomeruli. Another cytokine, TGF-β1, which is fibrosis, also highly expressed In present study, we report induces through TGF-β1/Smads signal transduction pathway. This supported by following findings:...
Kindlin-2 is involved in activating the integrin signaling pathway which plays an important role regulating cancer cell invasion. However, of kindlin-2 may vary among types. The aim this study was to explore possible association between and clear renal carcinoma (ccRCC), its potential prognosis ccRCC. Immunohistochemistry assays were used examine expression levels tissues obtained from 336 patients with correlation pathologic variables then analyzed. In addition, survival time analyzed by...