A5047333154- Paleontology and Stratigraphy of Fossils
- Marine Biology and Ecology Research
- Geology and Paleoclimatology Research
- Paleontology and Evolutionary Biology
- Evolution and Paleontology Studies
- Cephalopods and Marine Biology
- Geological and Geophysical Studies
- Retinoids in leukemia and cellular processes
- Geochemistry and Elemental Analysis
- Geological formations and processes
- Autophagy in Disease and Therapy
- Caveolin-1 and cellular processes
- Subterranean biodiversity and taxonomy
- Cannabis and Cannabinoid Research
- Glaucoma and retinal disorders
- Fossil Insects in Amber
- MicroRNA in disease regulation
- GaN-based semiconductor devices and materials
- Cancer, Hypoxia, and Metabolism
- Diet, Metabolism, and Disease
- Angiogenesis and VEGF in Cancer
- Ion channel regulation and function
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
Yunnan University
2011-2025
Anhui Medical University
2021-2025
China University of Mining and Technology
2024
Harbin Medical University
2012-2024
Museum of Heilongjiang Province
2022-2024
Wenzhou Medical University
2011-2024
Affiliated Eye Hospital of Wenzhou Medical College
2011-2024
Yunnan Normal University
2024
Chengdu University of Technology
2020-2023
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2020-2023
Abstract: We redescribe the morphology of Yohoia tenuis (Chelicerata sensu lato ) from Cambrian Burgess Shale Lagerstätte. The most anterior, prominent, so‐called great appendage changes throughout ontogeny. While its principal remains unaltered, length ratios certain parts change significantly. Furthermore, it possesses a special jack‐knifing mechanism, i.e. an elbow joint: articulation between distal one two peduncle elements and proximal four spine‐bearing claw elements. This might have...
The Cambrian Stage 3 Chengjiang biota in South China is one of the most influential Konservat-Lagerstätten worldwide thanks to fossilization diverse non-biomineralizing organisms through pyritization. Despite their contributions understanding evolution early animals, several species remain poorly known owing scarcity and/or incomplete preservation. Here, we use micro-computed tomography reveal detail ventral appendage organization enigmatic non-trilobite artiopod Pygmaclypeatus daziensis...
The promyelocytic leukemia protein (PML) is essential in the assembly of dynamic subnuclear structures called PML nuclear bodies (PML-NBs), which are involved regulating diverse cellular functions. However, possibility being cardiac disease has not been examined. In mice undergoing transverse aortic constriction (TAC) and arsenic trioxide (ATO) injection, transforming growth factor β1 (TGF-β1) was upregulated along with alteration SUMOylation. cultured neonatal mouse fibroblasts (NMCFs),...
A three-dimensionally preserved 2-mm-long larva of the arthropod Leanchoilia illecebrosa from 520-million-year-old early Cambrian Chengjiang biota China represents first evidence, to our knowledge, such an developmental stage in a short-great-appendage (SGA) arthropod. The possesses pair three-fingered great appendages, hypostome, and four pairs well-developed biramous appendages. More posteriorly, series rudimentary limb Anlagen revealed by X-ray microcomputed tomography shows gradient...
Artiopodan euarthropods represent common and abundant faunal components in sites with exceptional preservation during the Cambrian. The Chengjiang biota South China contains numerous taxa that are exclusively known from this deposit, thus offer a unique perspective on euarthropod diversity early One such endemic taxon is non-trilobite artiopodan Sinoburius lunaris, which has been for approximately three decades, but few details of its anatomy well understood due to rarity within Chengjiang,...
Arsenic trioxide (ATO) is an effective therapeutic agent against acute promyelocytic leukemia (APL); however, its anti-tumor effect on solid tumors such as colorectal cancer (CRC) still in debate. Ascorbic acid (AA) also produces a selective cytotoxic activity tumor cells. Here, we exploit the potential benefit of ATO/AA combination generating cytotoxicity to CRC cells, which may lay ground work for combinational chemotherapy CRCs. According results, found that ATO and AA effectively...
Autism spectrum disorder (ASD) is a group of developmental disabilities, the aetiology which remains elusive. The endocannabinoid (eCB) system modulates neurotransmission and neuronal plasticity. Evidence points to involvement this neuromodulatory in pathophysiology ASD. We investigated whether there disruption eCB ASD pharmacological modulation might offer therapeutic potential. examined three major components system—endogenous cannabinoids, their receptors associated enzymes—in children as...
Abstract Phylogenetic analysis demonstrates that Kuamaia lata , a helmetiid euarthropod from the lower Cambrian (Series 2, Stage 3) Chengjiang Konservat-Lagerstätte, nests robustly within Artiopoda, clade including trilobitomorphs. Microtomography of new specimens K . reveals details morphology, notably six-segmented head and raptorial frontal appendages, latter contrasting with filiform antennae considered to be diagnostic character Artiopoda. analyses demonstrate appendage is...
More than half a billion years ago, high diversity of organisms appeared in the fossil record. All major clades we know today already existed, and arthropods dominated marine faunas. Many were equipped with pair elaborated compound eyes on top movable eye stalks. Some them also possessed 3-4 small single-aperture eyes, so-called median eyes. Just trilobites sessile dorsal One eyes/lateral is considered plesiomorphic common trait for euarthropods. Here, describe an arthropod that two...
HYD-PEP06, an endostatin-modified polypeptide, has been shown to produce effective anti-colorectal carcinoma effects through inhibiting epithelial–mesenchymal transition (EMT). However, whether HYD-PEP06 similar suppressive effect on hepatocellular (HCC) remained unknown. In this study, inhibited metastasis and EMT but not proliferation in vitro. Cignal finder pathway reporter array Western blot analysis revealed that suppressed HCCLM3 cell by the PI3K/AKT pathway. Moreover, exerted...
Abstract Background Various angiogenic regulators are involved in angiogenesis cascade. Transcription factor Ets-1 plays important role angiogenesis, remodeling of extracellular matrix, and tumor metastasis. target genes various stages new blood vessel formation include angiopoietin, matrix metalloproteinases (MMPs) the protease inhibitor maspin. Methods We used immunohistochemistry (IHC) to detect expression Ets-1, angiopoietin-2 (Ang-2) maspin ovarian analyzed relationship between these...
Abstract The last common ancestor of all living arthropods had biramous postantennal appendages, with an endopodite and exopodite branching off the limb base. Morphological evidence for homology these rami between crustaceans chelicerates has, however, been challenged by data from clonal composition knockout leg patterning genes. Cambrian arthropod fossils have cited as providing support competing hypotheses about biramy but shed little light on additional lateral outgrowths, known exites....
The artiopodans represent a diverse group of euarthropods with typically flattened dorsal exoskeleton that covers numerous pairs biramous ventral appendages, and which are ubiquitous faunal components the 518-million-year-old Chengjiang Lagerstätte in South China. Despite their abundance, several remain poorly known, such as large euarthropoda Retifacies abnormalis, Hou, Chen & Lu, 1989, is distinguished by presence mesh-like ornamentation on its exoskeleton. Although only few details were...
Background/Aims: Low ambient temperature is an important risk factor for cardiovascular diseases, and has been shown to lead cardiac hypertrophy. In this study, we aim investigate if Resveratrol may inhibit cold exposure-induced hypertrophy in mice, so clarify its molecular mechanism. Methods: Adult male mice were randomly assigned Control group (kept at room temperature), Cold low air range from 3°C 5°C) treatment (100mg/kg/day) eight weeks. HE staining, Masson staining Transmission...
Experimental allergic encephalomyelitis (EAE) can be induced in animal models by injecting the MOG35-55 peptide subcutaneously. Dendritic cells (DCs) that are located at immunization site phagocytose peptide. These DCs mature and migrate into nearest draining lymph nodes (dLNs), then present antigen, resulting activation of naive T cells. helper type 1 (Th1) Th17 primary involved EAE progression. All-trans-retinoic acid (AT-RA) has been shown to have beneficial effects on progression;...
Recent research indicates that the C-terminal Eps15 homology domain 1 is associated with epithelial growth factor receptor–mediated endocytosis recycling in non-small-cell lung cancer. The aim of this study was to determine clinical significance gene expression relation phosphorylation receptor patients breast Primary cancer samples from 306 were analyzed for 1, RAB11FIP3, and via immunohistochemistry. assessed a multivariate Cox regression analysis, Kaplan–Meier curves, log-rank test....
Ovarian cancer is often accompanied by the production of ascites, and patients with repeated ascites are associated chemotherapy resistance. The previous study confirmed that ovarian who developed after had elevated autophagy levels in precipitated cells, which was positively correlated MDR1 expression blood patients.In order to explore correlation between chemoresistant, we searched TCGA GEO database analyze LC3B MDR1, identified targeting miRNA LC3B. It verified dual luciferase miR-204 can...