A5100446563- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Vitamin C and Antioxidants Research
- Chemical synthesis and alkaloids
- Thyroid and Parathyroid Surgery
- Vitamin D Research Studies
- Polyamine Metabolism and Applications
- Plant-derived Lignans Synthesis and Bioactivity
- Biopolymer Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- Viral gastroenteritis research and epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Galectins and Cancer Biology
- Extracellular vesicles in disease
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Thyroid Cancer Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Traditional and Medicinal Uses of Annonaceae
- Cancer Research and Treatments
Harbin Medical University
2009-2022
Second Affiliated Hospital of Harbin Medical University
2020-2022
State Key Laboratory of Natural Medicine
2017
China Pharmaceutical University
2017
State Key Laboratory of Natural and Biomimetic Drugs
2013
Peking University
2013
Abstract Aims Nicotine, a major component of tobacco, is an important factor contributing to atherosclerosis. However, the molecular mechanisms underlying link between nicotine and atherosclerosis are unclear. As extracellular vesicles (EVs) involved in intercellular communication atherosclerosis, we investigated whether their influence on arterial pathophysiology under stimulation. Methods results EVs from serum smokers (smoker-EVs) were significantly increased exacerbated endothelial...
Arsenic trioxide (ATO) is an effective therapeutic agent against acute promyelocytic leukemia (APL); however, its anti-tumor effect on solid tumors such as colorectal cancer (CRC) still in debate. Ascorbic acid (AA) also produces a selective cytotoxic activity tumor cells. Here, we exploit the potential benefit of ATO/AA combination generating cytotoxicity to CRC cells, which may lay ground work for combinational chemotherapy CRCs. According results, found that ATO and AA effectively...
Despite significant advances in transplantation, acute cellular rejection (AR) remains a major obstacle that is most prevalent the first months post heart transplantation (HT). Current treatments require high doses of immunosuppressive drugs followed by maintenance therapies have systemic side effects including early infection. In this study, we attempted to prevent AR with myocardial-targeted galectin-7-siRNA delivery method using cationic microbubbles (CMBs) combined ultrasound targeted...
Schisandrin B has received much attention owing to its various biological activities. The present study was aimed at the formulation development of schisandrin and investigation pharmacokinetic profiles, distribution excretion in Sprague-Dawley rats. In this study, micronized particles with particle size 10-20 μm were chosen as research object. Chromatographic separation carried out on a BDS Hypersil C18 column (50 × 2.1 mm, i.d. 3.5 μm). deoxyschizandrin (internal standard) detected without...
Streptomyces albus Y07, a strain which could produce ε-Poly-L-lysine (ε-PL) had been screened in our previous study. The fermentation conditions for production were further optimized through response surface method this work. A central composite design was adopted to study the effect of culture volume, shaking speed, initial pH, as well inoculation amount on ε-PL production. quadratic polynomial equation obtained by multiple regression analysis. follow: accuracy and general availability...
Objective To develop neural stem cells(NSCs) which can stably express exogenous brain-derived neurotrophic factor(BDNF) in vitro. Methods NSCs from the subependymal zone of embry-onic day 14.5(E14.5) rat brain were purified by limiting dilution assay and then infected with supernatant recombinant retrovirus pLXSN-BDNF pLXSN. The original copy numbers gene templates three groups NSCs(pLXSN-BDNF viral infection group, pLXSN control group) detected fluorescent quantitative PCR(FQ-PCR). ELISA...