A5088824453- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Circular RNAs in diseases
- Chemokine receptors and signaling
- Thermochemical Biomass Conversion Processes
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Bone health and treatments
- Advanced biosensing and bioanalysis techniques
- Advanced Combustion Engine Technologies
- Catalytic Processes in Materials Science
- MicroRNA in disease regulation
- Multiple Sclerosis Research Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Petroleum Processing and Analysis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cyclone Separators and Fluid Dynamics
- Cancer, Lipids, and Metabolism
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- Immune cells in cancer
- Bone Metabolism and Diseases
- Analytical Chemistry and Chromatography
- T-cell and B-cell Immunology
Winthrop Rockefeller Foundation
2021-2025
University of Arkansas for Medical Sciences
2021-2025
Nantong University
2025
Nanjing Medical University
2025
Yancheng Third People's Hospital
2025
Affiliated Hospital of Nantong University
2025
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Third Xiangya Hospital
2023
Central South University
2023
Significance Stress cannot be avoided in the present competitive world, and chronic stress is associated with detrimental effects on physical health, including progression of inflammatory bowel disease (IBD). However, mechanisms behind it are less clearly understood. This study showed that disturbed gut microbiota, thereby triggering immune system response facilitating dextran sulfate sodium-induced colitis. Results also stress-deficient expression mucin-2 lysozyme, which may contribute to...
Abstract Anti-multiple myeloma B cell maturation antigen (BCMA)-specific chimeric receptor (CAR) T-cell therapies represent a promising treatment strategy with high response rates in myeloma. However, durable cures following anti-BCMA CAR-T of are rare. One potential reason is that small subset minimal residual cells seeds relapse. Residual BCMA-CAR-T-mediated show less-differentiated features and express stem-like genes, including CD24. CD24-positive large fraction after BCMA-CAR-T therapy....
Psychologic depression has been shown to dysregulate the immune system and promote tumor progression. The aim of this study is investigate how psychologic alters profiles in prostate cancer.We used a murine model Myc-CaP tumor-bearing immunocompetent FVB mice Hi-myc presenting with spontaneous cancer. Transwell migration coculture assays were evaluate myeloid cell trafficking cytokine profile changes evoked by cells that had treated norepinephrine (NE), major elevated neurotransmitter...
Timely and rapid detection of biomarkers is extremely important for the diagnosis treatment diseases. However, going to hospital test most common way. People need spend a lot money time on various tests potential disease detection. To make more convenient affordable, we propose paper-based aptasensor platform in this work. This device based cellulose paper, which three-electrode system microfluidic channels are fabricated. Meanwhile, novel nanomaterials consisting amino redox...
It has been reported that long non-coding RNA HOXA distal transcript antisense (lncRNA HOTTIP) functions as a tumor promoter in colorectal cancer (CRC). Hence, we paid attention to exploring whether exosomes could carry lncRNA HOTTIP affect the mitomycin resistance CRC and identify underlying mechanisms. High expression of was detected mitomycin-resistant cells. Inhibition reduced resistance. In co-culture system cells or their derived with cells, found be transferred into parental via...
Abstract The transcription factor, forkhead box M1 (FOXM1), has been implicated in the natural history and outcome of newly diagnosed high-risk myeloma (HRMM) relapsed/refractory (RRMM), but mechanism with which FOXM1 promotes growth neoplastic plasma cells is poorly understood. Here we show that a positive regulator metabolism greatly impacts bioenergetic pathways glycolysis oxidative phosphorylation (OxPhos). Using FOXM1-deficient as principal experimental model system, find increases...
Multiple myeloma (MM) growth is supported by an immune-tolerant bone marrow microenvironment. Here, we find that loss of Never in mitosis gene A (NIMA)-related kinase 2 (NEK2) tumor microenvironmental cells associated with MM suppression. The absence NEK2 leads to both fewer tumor-associated macrophages (TAMs) and inhibitory T cells. expression myeloid progenitor promotes the generation functional TAMs when stimulated conditional medium. Clinically, high increased CD8+ effector memory cells,...
Multiple myeloma (MM) is a malignancy of terminally differentiated B-cells that localized primarily in the bone marrow (BM) but also can be present peripheral blood and tissue/organs [...].
Objective: The study aims to explore the effects of music therapy combined with hospice care on quality life and negative emotions elderly patients advanced breast cancer. Methods: A retrospective analysis was performed 240 cancer who were treated at Yancheng Third People’s Hospital First from January 2020 June 2024. classified into group group, 120 cases in each group. received only care, while care. Quality [Functional Assessment Cancer Therapy-Breast (FACT-B)], pain level [visual analog...
Significance In this study, we demonstrate that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Gα i1/3 ) regulate the downstream signaling pathways of Toll-like receptor 4 (TLR4). We show Gα form complexes containing pattern recognition (PRR) CD14 growth factor binding 2 (Grb2)-associated (Gab1), which are required for activation PI3K-Akt NF-κB activation. Besides, act at both plasma membrane endosome levels involved in TLR4 endocytosis. Furthermore, participated...
Microbiota and its induced inflammation in colorectal mucosa have been considered risk factors for the development of carcinogenesis. Previous studies demonstrated that coexisting elements microbiota gut, such as short chain fatty acids (SCFAs) lipopolysaccharides (LPS), which exhibited regulatory effects on intestinal epithelial cells individually. Unfortunately, association between butyrate toll-like receptor (TLR) signaling pathway colon cancer is not fully elucidated. In present study,...
Abstract We describe a novel genetic locus, wunen (wun), required for guidance of germ cell migration in early Drosophila development. Loss wun function does not abolish movement but disrupts the orientation motion causing cells to disperse even though their normal target, somatic gonad, is well formed. demonstrate that product this gene enables signal pass from soma line and propose selectively stabilize certain cytoplasmic extensions resulting oriented movement. To characterize factor, we...
Osteolytic bone disease is a hallmark of multiple myeloma (MM). A significant fraction (~20%) MM patients do not develop osteolytic lesions (OLs). The molecular basis for the absence in understood. We combined PET-CT and gene expression profiling (GEP) purified BM CD138+ cells from 512 newly diagnosed to reveal that elevated cystatin M/E (CST6) was significantly associated with OL MM. An enzyme-linked immunosorbent assay revealed strong correlation between CST6 levels serum/plasma mRNA...
Abstract Multiple myeloma (MM) is a heterogenous plasma cell malignancy, for which the established prognostic models exhibit limitations in capturing full spectrum of outcome variability. Leveraging single-cell RNA-sequencing data, we developed novel gene signature. We evaluated and validated associations resulting malignancy (PBM) score with disease state, progression clinical outcomes using data from five independent studies consisting 2115 samples (1978 MM, 65 monoclonal gammopathy...
Chromatin remodeling during sperm maturation could erase epigenetic landmarks on the paternal genome, creating a challenge for its reestablishment fertilization. Here, we show that selective retention of chromosomal protein in mature protects identity telomeres Drosophila . The ms(3)k81 ( k81 ) gene is duplication hiphop encodes telomeric protein. Although HipHop somatic cells, K81 produced exclusively males and localizes to postmitotic including sperm. In embryos fathered by mutants,...