A5032960470- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Inhalation and Respiratory Drug Delivery
- FOXO transcription factor regulation
- Pediatric health and respiratory diseases
- Air Quality and Health Impacts
- Viral gastroenteritis research and epidemiology
- Cancer Research and Treatments
- Asthma and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Protein Degradation and Inhibitors
- Immunotherapy and Immune Responses
- Viral Infectious Diseases and Gene Expression in Insects
- Helicobacter pylori-related gastroenterology studies
- Virus-based gene therapy research
- Nanoparticles: synthesis and applications
- Galectins and Cancer Biology
- Immune cells in cancer
- Graphene and Nanomaterials Applications
- CAR-T cell therapy research
- Escherichia coli research studies
- Medical Research and Treatments
- Regional Development and Environment
State Key Laboratory of Electrical Insulation and Power Equipment
2024
Nanjing Medical University
2023-2024
Yangtze University
2024
Jiangsu University
2024
University of Iowa
2014-2023
Yuhuangding Hospital
2023
Qingdao University
2023
Anhui University of Science and Technology
2023
Capital Medical University
2004-2022
Peking University
2022
Abstract The transcription factor, forkhead box M1 (FOXM1), has been implicated in the natural history and outcome of newly diagnosed high-risk myeloma (HRMM) relapsed/refractory (RRMM), but mechanism with which FOXM1 promotes growth neoplastic plasma cells is poorly understood. Here we show that a positive regulator metabolism greatly impacts bioenergetic pathways glycolysis oxidative phosphorylation (OxPhos). Using FOXM1-deficient as principal experimental model system, find increases...
Abstract Asthma is a common inflammatory disease involving cross-talk between innate and adaptive immunity. We reveal that antibacterial immunity protein, peptidoglycan recognition protein (Pglyrp)1, involved in the development of allergic asthma. Pglyrp1−/− mice developed less severe asthma than wild-type (WT) following sensitization with house dust mite (allergen) (HDM). HDM-sensitized mice, compared WT had diminished bronchial hyperresponsiveness (lung airway resistance); numbers...
Abstract Expression of IL-7Rα (CD127) has been suggested as a major determinant in the survival memory T cell precursors. We investigated whether constitutive expression on cells increased expansion and/or decreased contraction endogenous Ag-specific CD4 and CD8 following infection with Listeria monocytogenes. The results indicate that alone was not enough to impart an or advantage responding infection, did increase numbers over those observed wild-type controls. Constitutive allow for...
Abstract Aberrant immune response and changes in the gut microflora are main causes of inflammatory bowel disease (IBD). Peptidoglycan recognition proteins (Pglyrp1, Pglyrp2, Pglyrp3, Pglyrp4) bactericidal innate immunity that maintain normal microbiome, protect against experimental colitis, associated with IBD humans. Nucleotide-binding oligomerization domain 2 (Nod2) is an intracellular bacterial sensor may be required for maintaining microbiome. Mutations Nod2 strongly Crohn’s disease,...
Following up on previous work demonstrating the involvement of transcription factor forkhead box M1 (FOXM1) in biology and outcome a high-risk subset newly diagnosed multiple myeloma (nMM), this study evaluated whether FOXM1 gene expression may be further upregulated upon tumor recurrence patients with relapsed (rMM). Also assessed was hypothesis that increased levels diminish sensitivity cells to commonly used drugs, such as proteasome inhibitor bortezomib (Bz) DNA intercalator doxorubicin (Dox).
Abstract Background and aims The function of interleukin ( IL )‐10‐producing B cells (B10 cell) is compromised in patients with allergic diseases. Protease‐activated receptor PAR )‐2 has immunoregulatory functions. This study aimed to elucidate the role 2 suppression ‐10 expression peripheral cells. Methods Peripheral blood were collected from rhinitis AR ). A correlation between Bcl2‐like protein 12 (Bcl2L12) was analyzed. An mouse model developed. Results We observed that lower airway...
It has been shown that inhalation exposure to copper oxide nanoparticles (CuO NPs) results in pulmonary inflammation. However, immunomodulatory consequences after CuO NP have less explored. We tested the effect of aerosols on immune responses healthy, house dust mite (HDM) asthmatic, or allergen immunotherapy (AIT)-treated asthmatic mice (BALB/c, females). The AIT consisted a vaccine comprising HDM allergens and CpG-loaded (CpG NPs). treatment involved being immunized (via subcutaneous (sc)...
KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice
GA binding protein (GABP) is a ubiquitously expressed Ets family transcription factor that consists of two subunits, GABPalpha and GABPbeta. binds to DNA, GABPbeta heterodimerizes with possesses the ability transactivate target genes. Our previous studies using GABPalpha-deficient mice revealed required for development both T B cells. Two splice variants are generated from Gabpb1 locus differ in their carboxy-terminal lengths sequences. The longer isoform (GABPbeta1L) can homodimerize thus...
GA-binding protein (GABP) is the only Ets family transcription factor that functions as a heterodimer. The GABPα subunit binds to DNA, and GABPβ possesses ability transactivate target genes. Inactivation of caused embryonic lethality defective lymphocyte development immune responses. There are 3 isoforms subunit, but whether they have distinct has not been addressed. In this study, we selectively ablated expression GABPβ2 using gene trap strategy. GABPβ2-deficient mice were viable had normal...
To evaluate the potentiality of applying gene therapy to bacterial infections, especially for preventing infection in high-risk patients, we investigated protection mice from challenge with lethal Escherichia coli by adeno-associated virus serotype 2 (AAV2)-mediated transfer a chimeric BPI23-Fcgamma1 gene, which consisted human bactericidal/permeability-increasing protein (BPI) encoding functional N terminus (amino acid residues 1 199) BPI and an Fcgamma1 Fc segment immunoglobulin G1. Here...