A5101402934- Prostate Cancer Treatment and Research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Minimally Invasive Surgical Techniques
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Abdominal vascular conditions and treatments
- Circular RNAs in diseases
- Protease and Inhibitor Mechanisms
- Bladder and Urothelial Cancer Treatments
- Tannin, Tannase and Anticancer Activities
- Cancer-related Molecular Pathways
- Biomedical Research and Pathophysiology
- Kruppel-like factors research
- CNS Lymphoma Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Hippo pathway signaling and YAP/TAZ
- Kidney Stones and Urolithiasis Treatments
Second Affiliated Hospital of Nanjing Medical University
2021-2025
Nanjing University of Chinese Medicine
2017-2024
Jiangsu Province Hospital
2014-2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Nanjing Traditional Chinese Medicine Hospital
2016
Nanjing University
2016
Bladder cancer (BC) is one of the most common cancers in world, with high morbidity and mortality. It essential to develop a non-invasive, highly accurate, simple method for BC diagnosis. This work proposed fluorescent biosensor based on inorganic nanoflares combined DNAzyme walker simultaneous detection exosomal microRNAs (miRNAs). was constructed Au nanoparticle (AuNP) modified carbon dot (CD)-labeled substrates strands (AuNP@CDs nanoflares-DNAzyme, APCD). In presence target miRNAs,...
Abstract Despite therapeutic improvements in prostate cancer treatment, the recurrence and mortality rates are still high, underlying mechanisms need further study. Non‐SMC Condensin II Complex Subunit D3 (NCAPD3) is a subunit of condensin complex, mainly involved mitotic chromosome condensation cells. This study aimed to figure out detailed by which NCAPD3 contributed development. Clinical samples cell lines were used measure expression genes quantitative real‐time RT‐PCR (qRT‐PCR),...
Significance In this study, we demonstrate that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Gα i1/3 ) regulate the downstream signaling pathways of Toll-like receptor 4 (TLR4). We show Gα form complexes containing pattern recognition (PRR) CD14 growth factor binding 2 (Grb2)-associated (Gab1), which are required for activation PI3K-Akt NF-κB activation. Besides, act at both plasma membrane endosome levels involved in TLR4 endocytosis. Furthermore, participated...
MicroRNAs (miRNAs) are a class of small non-coding RNAs (18-25 nucleotides) which post-transcriptionally regulate gene expression by negatively regulating the stability or translational efficiency their target mRNAs. This study aimed to determine function miR-154-5p in prostate cancer (PCa) cells and identify novel molecular targets regulated miR-154-5p.The effects forced E2F transcription factor 5 (E2F5) knockdown on PCa were evaluated cell proliferation, flow cytometry, migration invasion...
In a single-port robotic system where the 3D endoscope possesses two bending segments, only point light sources can be integrated at tip due to space limitations. However, usually provide non-uniform illumination, causing endoscopic images appear bright in centre and dark near corners.Based on inverse square law for illuminance, an initial luminance weighting is first proposed increase image uniformity. Then, saturation-based model finalise avoid overexposure colour discrepancy, while...
MicroRNA-520c (miR-520c) and microRNA-373 (miR-373) are originally characterized as both oncogenes tumor suppressors in different types of human cancers. In this study, we found that translation mRNA MT1-MMP, an oncogene related to metastasis, was well inhibited by miR-520c miR-373 several cancer cells. Our experimental data demonstrated these two microRNAs the MT1-MMP down-regulated its proteolytic enzyme activities via targeting 3'UTR further decreased activating proMMP2 into active MMP2...
// Long Fan 1, * , Qingyi Zhu 2, Li Liu 3 Cuicui 1 Haojie Huang 4 Shan Lu and Ping Jiangsu Province Key Laboratory for Molecular Medicine Biotechnology, Life Science College, Nanjing Normal University, Nanjing, Jiangsu, China 2 Department of Urology, Hospital TCM, Biology, Mayo Clinic Cancer Center, College Medicine, Rochester, MN, USA These authors have contributed equally to this work Correspondence to: Liu, email: 08201@njnu.edu.cn Huang, huanghj86@gmail.com Keywords: androgen, androgen...
Abstract Traditional Chinese medicine ( TCM ) has a combined therapeutic result in cancer treatment by integrating holistic and local therapeutical effects, which can enhance the curative effect reduce side effect. In this study, we analyzed of CFF ‐1 (alcohol extract from an anticancer compound medicine) on prostate PC a) cell lines studied detail mechanism death induced vitro vivo. From our data, found for first time that obviously arrested cycle G1 phase, decreased viability then...
Isorhapontigenin (ISO), a naturally phytopolyphenol compound existing in Chinese herb, apples, and various vegetables, has attracted extensive interest recent years for its diverse pharmacological characteristics. Increasing evidences reveal that ISO can inhibit cancer cell growth by induced apoptosis, however, the molecular mechanisms is not fully understood. In this study, we found first time apparently inhibition apoptosis targeting EGFR downstream signal pathways prostate (PCa) cells...
Phloretin is a flavonoid existed in various plants and has been reported to possess anticarcinogenic activity. However, the anticancer mechanism of phloretin prostate cancer (PCa) remains unclear. Here, our vitro vivo experimental data demonstrate that inhibits phosphorylation activation EGFR then its downstream PI3K/AKT MEK/ERK1/2 pathways PCa cells. Inhibition these two further decreases expression Sp1 by inhibiting gene transcription, induces degradation protein GSK3β phosphorylation,...
Prostate adenocarcinoma (PRAD) is a common malignancy with increasing morbidity and mortality. Kinetochore scaffold 1 (KNL1) has been reported to be involved in tumor progression prognosis other tumors, but its role PRAD not detail. KNL1 expression analysis, clinicopathological parameters prognostic correlation molecular interaction network functional abdominal muscle analysis immune infiltration by using multiple online databases downloaded profile. The results suggest that highly expressed...
Traditional Chinese medicine (TCM) has the synergistic effect of combination a single ingredient and monomer, systemic local therapeutic effects in cancer treatment, through which TCM is able to enhance curative reduce side effects. The present study analyzed TCM‑1 (an anti‑cancer TCM) on prostate (PCa) cell lines, studied detail mechanism death induced by vitro vivo. From results, it was identified for first time, best our knowledge, that arrested cycle at G1 phase, decreased viability...
Abstract Background Androgen receptor (AR) is an essential transcriptional factor that contributes to the development and progression of prostate cancer (PCa). NCAPD3 a component condensin II complex plays critical role in cell mitosis by regulating chromosome condensation; however, relationship between AR remains unknown. Methods Transcriptome sequencing assay carried out analyze expression NCAP family clinic samples. Chromatin immunoprecipitation (ChIP) sequencing, ChIP assay,...
Bst-2 (bone marrow stromal cell antigen 2) is a type II membrane protein, and it acts as tetherin to inhibit virion releasing from infectious cells. Membrane type-1 matrix metalloproteinase (MT1-MMP) protease. It plays pivotal role in cellular growth migration by activating proMMP-2 into active MMP2. Our results here elaborate that MT1-MMP inhibits the activity of interacting with Bst-2, cytoplasmic domains both play critical roles within this interaction. Based on our experimental data,...
To evaluate the operative outcome of use intracavitary retractors in transumbilical laparoendoscopic single-site (LESS) adrenalectomy comparison with conventional multiport procedure.
Prostate cancer (PCa) is a common malignancy in elderly men. We have applied Traditional Chinese Medicine CFF-1 clinical treatments for PCa several years. Here, we aimed to identify the underlying mechanism of on using network pharmacology and experimental validation. Active ingredients, potential targets were acquired from public databases. Subsequently, protein-protein interaction (PPI) herbs-active ingredients-target was constructed. A prognostic model also constructed based key targets....