A5101794491- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Circular RNAs in diseases
- Ureteral procedures and complications
- Supramolecular Self-Assembly in Materials
- Pediatric Urology and Nephrology Studies
- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Protein Structure and Dynamics
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Vascular anomalies and interventions
- Renal and Vascular Pathologies
- Glycosylation and Glycoproteins Research
- Polydiacetylene-based materials and applications
- Biochemical effects in animals
- Renal Transplantation Outcomes and Treatments
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Nuts composition and effects
- Technology and Security Systems
- Protein Degradation and Inhibitors
- Hippo pathway signaling and YAP/TAZ
Union Hospital
2019-2024
Huazhong University of Science and Technology
2010-2024
Jiangsu Province Hospital
2013-2021
Nanjing Medical University
2013-2021
Wuhan Union Hospital
2019-2021
Tongji Hospital
2019
Shanxi Medical University
2016
Shaanxi Provincial People's Hospital
2016
University of Reading
2010-2012
Constellation Technology (United States)
2011
The self-assembly and hydrogelation properties of two Fmoc-tripeptides [Fmoc = N-(fluorenyl-9-methoxycarbonyl)] are investigated, in borate buffer other basic solutions. A remarkable difference is observed comparing Fmoc-VLK(Boc) with Fmoc-K(Boc)LV, both containing K protected by Nε-tert-butyloxycarbonate (Boc). In buffer, the former peptide forms highly anisotropic fibrils which show local alignment, hydrogels flow-aligning properties. contrast, Fmoc-K(Boc)LV branched that produce isotropic...
Management of a long proximal ureteral stricture is challenging. Lingual mucosal graft ureteroplasty (LMGU) novel minimally invasive technique for reconstruction that avoids the morbidity bowel interposition or autotransplantation.To evaluate long-term effectiveness LMGU managing long, complex strictures in multi-institutional cohort patients.This retrospective study involved data 41 patients treated with at three centers between June 2015 and January 2021.LMGU was performed using either an...
The self-assembly of tripeptides based on the RGD cell adhesion motif is investigated. Two containing Fmoc [N-(fluorenyl)-9-methoxycarbonyl] aromatic unit were synthesized, Fmoc-RGD and a control peptide scrambled sequence, Fmoc-GRD. used to via stacking interactions. hydrogelation properties two Fmoc-tripeptides are compared. Both form well defined amyloid fibrils (as shown by cryo-TEM SAXS) with β-sheet features in their circular dichroism FTIR spectra. peptides self-supporting hydrogels,...
Metabolic adaptations are emerging hallmarks of cancer progression and cellular transformation. Clear cell renal carcinoma (ccRCC) is a metabolic disease defined histologically by lipid accumulation storage, which promote tumor survival; however, the significance eliminating remains unclear. Here, we demonstrate that melatonin activates transcriptional coactivator peroxisome proliferator-activated receptor gamma 1A (PGC1A) uncoupling protein 1 (UCP1)-dependent autophagy browning program to...
The dipeptide l-carnosine has a number of important biological properties. Here, we explore the effect attachment bulky hydrophobic aromatic unit, Fmoc [N-(fluorenyl-9-methoxycarbonyl)] on self-assembly Fmoc-l-carnosine, i.e., Fmoc-β-alanine-histidine (Fmoc-βAH). It is shown that Fmoc-βAH forms well-defined amyloid fibrils containing β sheets above critical aggregation concentration, which determined from pyrene and ThT fluorescence experiments. Twisted were imaged by cryogenic transmission...
The self-assembly of the peptide amphiphile (PA) hexadecyl-(β-alanine-histidine) is examined in aqueous solution, along with its mixtures multilamellar vesicles formed by DPPC (dipalmitoyl phosphatidylcholine). This PA, denoted C(16)-βAH, contains a dipeptide headgroup corresponding to bioactive molecule L-carnosine. It found self-assemble into nanotapes based on stacked layers molecules. Bilayers are coexist monolayers which PA molecules pack alternating up-down arrangement so that...
Long noncoding RNAs (lncRNAs) have emerged as important regulators and biomarkers of tumor development progression. This study investigated the clinical significance, biological functions, underlying mechanisms long intergenic non-protein-coding RNA 1296 (LINC01296) in prostate cancer.LINC01296 expression cancer tissues cell lines was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The correlation between LINC01296 clinicopathologic characteristics analyzed using...
Emerging evidence indicates that castration-resistant prostate cancer (CRPC) is often driven by constitutively active androgen receptor (AR) or its V7 splice variant (AR-V7) and commonly becomes resistant to endocrine therapy. The aim of this work evaluate the function a kinesin protein, KIF4A, in regulating AR/AR-V7 therapy resistance.We examined KIF4A expression clinical specimens IHC. Regulated pathways were investigated qRT-PCR, immunoblot analysis, immunoprecipitation, luciferase...
Abstract Prostate cancer (PCa) is the second leading cause of death among American men. Increasing evidence has shown that long noncoding RNAs (lncRNAs) play important roles in tumorigenesis PCa. In this study, we explored biological functions small nucleolar RNA host gene 12 (SNHG12) and investigated interaction between miR‐133b SNHG12 progression Data was downloaded from The Cancer Genome Atlas Human Metastasis Database, clinicopathological characteristics were analyzed with relapse‐free...
Nanhaia speciosa is a valuable industrial crop known for its significant edible and medicinal properties, attributed to abundance of secondary metabolites. This study aims elucidate the genetic relationships among N. speciosa, enhance species identification accuracy, select genetically stable, high-quality germplasms speciosa. To achieve this, we conducted chloroplast gene amplification sequencing, alongside an analysis agronomic traits 19 germplasms. Additionally, non-targeted metabolomic...
Self-assembly in aqueous solution has been investigated for two Fmoc [Fmoc = N-(fluorenyl)-9-methoxycarbonyl] tetrapeptides comprising the RGDS cell adhesion motif from fibronectin or scrambled sequence GRDS. The hydrophobic unit confers amphiphilicity on molecules, and introduces aromatic stacking interactions. Circular dichroism FTIR spectroscopy show that self-assembly of both peptides at low concentration is dominated by interactions among units, although Fmoc-GRDS shows β-sheet...
The purpose of this study was to elucidate the molecular mechanisms microRNA-205 (miR-205) as a tumor suppressor in prostate cancer (PCa).In present study, microRNA microarray analysis suggested that expression miR-205 significantly decreased advanced PCa compared with early PCa.Real-time PCR also indicated tissues non-cancerous tissues.Moreover, has been demonstrated be associated clinicopathological stage and total/free prostate-specific antigen (PSA) level PCa.Functional analyses showed...
MicroRNAs (miRNAs) are a class of small non-coding RNAs (18-25 nucleotides) which post-transcriptionally regulate gene expression by negatively regulating the stability or translational efficiency their target mRNAs. This study aimed to determine function miR-154-5p in prostate cancer (PCa) cells and identify novel molecular targets regulated miR-154-5p.The effects forced E2F transcription factor 5 (E2F5) knockdown on PCa were evaluated cell proliferation, flow cytometry, migration invasion...
Notwithstanding the researches on biomarkers and targeted therapies in renal cell carcinomas (RCC) have made progress last decades, application of therapy agents for RCC clinic are restricted because their limitation or side effects. Liver X receptors (LXRs) NLRP3 inflammasome been research hotspots recent years. In our study, we integrated bioinformatics analysis, molecular biology experiments biological function to study roles LXRα RCC. The demonstrated that elevated expression is...
Increasing evidence implicates long noncoding RNAs (lncRNAs), a class of >200 nucleotides in length, the development cancer. However, mechanism underlying effects lncRNAs prostate cancer (PCa) remains to be elucidated. The present study aimed investigate role lncRNA‑THBS4‑003 pathogensis PCa. In study, microarray containing 8,277 lncRNA probes and 32,207 mRNA were used identify dysregulated mRNAs three patients with PCa, reverse transcription‑quantitative polymerase chain reaction was...
Renal cell carcinoma (RCC) is the most frequent malignant tumor of kidney. 30% patients with RCC are diagnosed at an advanced stage. Clear renal (ccRCC) common pathological subtype RCC. Currently, ccRCC lacks reliable diagnostic and prognostic markers. We explored potential SAA1 as a marker for ccRCC. In this study, we mined analyzed public cancer databases (TCGA, UALCAN GEPIA) to conclude that was up-regulated mRNA protein levels in further found hypomethylation promoter region responsible...
Renal cell carcinoma (RCC) is one of the most common malignant tumors urinary system and accounts for more than 90 % all renal tumors. Resistance to targeted therapy has emerged as a pivotal factor that contributes progressive deterioration patients with advanced RCC. Metabolic reprogramming hallmark tumorigenesis progression, an increasing body evidence indicating abnormal lipid metabolism plays crucial role in advancement clear carcinoma. Clarify precise mechanisms underlying drug...
Tumor recurrence and metastasis remain the major obstacles for successful treatment of patients diagnosed with prostate cancer (PCa). In recent years, long non-coding RNAs (lncRNAs) have been considered as key regulators tumor behavior. this study, we investigated biological role clinical relevance lncRNA LOC400891 in cancer. Using lncRNAs expression chips screening analysis, found target (LOC400891). Moreover, levels PCa tissues cell lines were evaluated by quantitative real-time PCR...
The self-assembly of a peptide based on sequence from the amyloid β but incorporating non-natural amino acid β-2-thienylalanine (2-Thi) has been investigated in aqueous and methanol solutions. AAKLVFF was used as design motif, replacing phenylalanine residues (F) with 2-Thi units to yield (2-Thi)(2-Thi)VLKAA. are expected confer interesting electronic properties due charge delocalization π-stacking. is shown form β-sheet-rich fibrils twisted morphology, both water solutions at sufficiently...
Long non-coding RNAs (lncRNAs) have emerged as key molecules in initiation and progression of prostate cancer (PCa). In this study, we aimed to explore the role lncRNA NAP1L6 development PCa.We identified that was over-expressed both PCa tissues cell lines by gene expression array profiling. The level 75 adjacent detected RT-PCR. Next, correlations between clinical features patients with were analyzed paired t-test or chi-squared test, its association patient prognosis assessed Kaplan-Meier...