A5001294492- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Exercise and Physiological Responses
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- Hedgehog Signaling Pathway Studies
- MicroRNA in disease regulation
- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Urological Disorders and Treatments
- Muscle Physiology and Disorders
- Pediatric Urology and Nephrology Studies
- Autophagy in Disease and Therapy
- Urinary Bladder and Prostate Research
- Lipid metabolism and disorders
- Muscle metabolism and nutrition
- Salivary Gland Disorders and Functions
- Inflammasome and immune disorders
- Occupational and environmental lung diseases
- Metabolomics and Mass Spectrometry Studies
- Neurogenetic and Muscular Disorders Research
- Tissue Engineering and Regenerative Medicine
- Virus-based gene therapy research
Logistics University of People's Armed Police Force
2013-2024
Chinese People's Armed Police Force
2008-2024
Tianjin University of Sport
2008-2023
Huazhong University of Science and Technology
2009-2022
Union Hospital
2009-2022
The University of Texas Health Science Center at Houston
2021
Brown Foundation
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2016
Soochow University
2013-2015
Soochow University
2014
Improving mitochondrial function has been proposed as a reasonable therapeutic strategy to reduce amyloid- β (A ) load and modify the progression of Alzheimer’s disease (AD). However, relationship between adaptation brain neuroprotection caused by physical exercise in AD is poorly understood. This study was undertaken investigate effects long-term treadmill on 8-oxoguanine DNA glycosylase-1 (OGG1) level, mtDNA oxidative damage, hippocampus APP/PS1 transgenic mouse model AD. In present study,...
Management of a long proximal ureteral stricture is challenging. Lingual mucosal graft ureteroplasty (LMGU) novel minimally invasive technique for reconstruction that avoids the morbidity bowel interposition or autotransplantation.To evaluate long-term effectiveness LMGU managing long, complex strictures in multi-institutional cohort patients.This retrospective study involved data 41 patients treated with at three centers between June 2015 and January 2021.LMGU was performed using either an...
Increasing evidence has indicated that acute strenuous exercise can induce a range of adverse reactions including oxidative stress and tissue inflammation. However, little is currently known regarding the mechanisms underlie regulation inflammatory response in myocardium during heavy exercise. This study evaluated mitochondrial function, NLRP3 inflammasome activation, autophagy‐related proteins to investigate mechanism rat The results function was adaptively regulated meet challenge...
Skeletal muscle is a heterogeneous tissue composed of different types fibers, demonstrating substantial plasticity. Physiological or pathological stimuli can induce transitions in fiber types. However, the precise regulatory mechanisms behind these remains unclear. This paper reviews classification and characteristics along with classical type transitions. Additionally, role exercise-induced disease intervention reviewed. Epigenetic pathways mediate cellular adaptations thus represent...
Spinal cord injury (SCI) is one of the most devastating neural injuries without effective therapeutic solutions. Astrocytes are predominant component scar. Understanding complex contributions reactive astrocytes to SCI pathophysiologies fundamentally important for developing strategies. We have studied molecular changes in environment and astrocyte-specific responses by astrocyte purification from injured spinal cords acute chronic stages. In addition protein-coding genes, we systematically...
Mitochondrial redox metabolism has long been recognized as being central to the effects of aging and development age-related pathologies in major oxidative organs. Consistent evidence shown that exercise is able retard onset impede progression by modifying mitochondrial oxidant–antioxidant homeostasis. Here we provide a broad overview research showing relationship between metabolism, exercise. We address part aspects reactive oxygen species (ROS) from superoxide production ROS...
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Abstract Background Oligodendrocytes, responsible for axon ensheathment, are critical central nervous system (CNS) development, function, and diseases. OLIG2 is an important transcription factor (TF) that acts during oligodendrocyte development performs distinct functions at different stages. Previous studies have shown lncRNAs (long non-coding RNAs; > 200 bp) but their roles not been systematically characterized regulation yet clear. Results We performed integrated study of genome-wide...
Abstract Background Gene transfer to salivary glands for use in treating both systemic and upper gastrointestinal tract diseases shows considerable potential. Numerous studies rodents demonstrate that can secrete transgenic secretory proteins either into saliva, primarily via the regulated pathway (RSP), or bloodstream, by constitutive (CSP). The purpose of present study was assess sorting characteristics human growth hormone (hGH), a RSP protein, erythropoietin (hEpo), CSP large animal...
Previously, using an adenoviral vector, we showed that miniature pigs could provide a valuable and affordable large animal model for pre-clinical gene therapy studies to correct parotid gland radiation damage. However, vectors lead short-term transgene expression and, ideally, more stable correction is required. In the present study, examined suitability of serotype 2 adeno-associated viral (AAV2) vector mediate transfer in glands these animals.Heparan sulfate proteoglycan was detected by...
SLC17A9 is a vesicular ATP transport protein that plays an important role in determining cell functions and the onset progression of different diseases. In this study, was initially identified as potential diagnostic prognostic risk biomarker for clear renal carcinoma (ccRCC). Then, aberrant expression levels were confirmed both lines clinical tissues. Mechanistically, could upregulate PTHLH, thus promoting epithelial-mesenchymal transition (EMT) ccRCC. Functionally, knockdown inhibited...
Introduction Skeletal muscle insulin resistance (IR) plays an important role in the pathogenesis of type 2 diabetes mellitus. is a heterogeneous tissue composed different fiber types that contribute distinctly to IR development. Glucose transport shows more protection slow-twitch muscles than fast-twitch during development, while mechanisms involved remain unclear. Therefore, we investigated mitochondrial unfolded protein response (UPRmt) distinct two IR. Methods Male Wistar rats were...
Objectives: The objective of this study is to evaluate the diagnosis and prognosis malignant mesothelioma tunica vaginalis testis through an additional 6 patients with urogenital mesothelioma.Methods: Six who underwent adequate surgical procedures histopathologic analysis from 1990 2009 were identified retrospectively reviewed.Results: between ages 26 78 years mesothelioma, 5 which originated in scrotum 1 spermatic cord. Histopathologic showed that CK5/6 calretinin positive all cases, cases...
Objective:The risk and vulnerability of Parkinson disease (PD) are especially high in the elderly. However, underlying causes unknown. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice useful tools to some extent for investigating PD-related problems due their PD-like symptoms. The study is aimed determine whether what mitochondrial-events during aging related with increased elderly MPTP.Methods:The MPTP were established by intraperitoneal injection MPTP, control animals injected...
As a common complication of sepsis, sepsis-associated encephalopathy (SAE) is characterized by diffuse brain dysfunction and neurological damage closely associated with long-term cognitive dysfunction. The dysregulated host response triggered neurotoxicity microglia an important cause in SAE. Resveratrol glycoside has anti-inflammatory antioxidant effects. However, there no evidence whether resveratrol could alleviate SAE.LPS administration was used to induce SAE mice. Step-down test (SDT)...
The objective of this study is to evaluate the diagnosis and prognosis malignant mesothelioma tunica vaginalis testis through an additional 6 patients with urogenital mesothelioma.Six who underwent adequate surgical procedures histopathologic analysis from 1990 2009 were identified retrospectively reviewed.Six between ages 26 78 years mesothelioma, 5 which originated in scrotum 1 spermatic cord. Histopathologic showed that CK5/6 calretinin positive all cases, cases for vimentin, case focal...