A5101819320- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Endometrial and Cervical Cancer Treatments
- Ureteral procedures and complications
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Cervical Cancer and HPV Research
- Wnt/β-catenin signaling in development and cancer
- Cancer Research and Treatments
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Kruppel-like factors research
- Arsenic contamination and mitigation
- Immune cells in cancer
- Rheology and Fluid Dynamics Studies
- Glutathione Transferases and Polymorphisms
- Nanocluster Synthesis and Applications
- HER2/EGFR in Cancer Research
- Congenital gastrointestinal and neural anomalies
- Block Copolymer Self-Assembly
- Freezing and Crystallization Processes
- Cancer, Hypoxia, and Metabolism
Union Hospital
2021-2024
Huazhong University of Science and Technology
2014-2024
Southern Medical University Shenzhen Hospital
2024
Shenzhen University
2023-2024
UnionPay (China)
2023
Guiyang Medical University
2023
Union Hospital
2014-2022
Qingdao University of Science and Technology
2021
Shandong University
2018-2020
Ministry of Education of the People's Republic of China
2018-2019
Tumor associated macrophage (TAM)-based immunotherapy has been presented as a promising strategy in cancer therapy. The combination of TAM-based with sorafenib (SF) could be conceivably quite more effective hepatocellular carcinoma (HCC) treatment. A co-delivery system was superior improving the co-accumulation two drugs tumor tissues for chemoimmunotherapy, while case selective targeting separated cells such and immune cells, novel targeted badly required. In this study, twin-like...
Management of a long proximal ureteral stricture is challenging. Lingual mucosal graft ureteroplasty (LMGU) novel minimally invasive technique for reconstruction that avoids the morbidity bowel interposition or autotransplantation.To evaluate long-term effectiveness LMGU managing long, complex strictures in multi-institutional cohort patients.This retrospective study involved data 41 patients treated with at three centers between June 2015 and January 2021.LMGU was performed using either an...
Histone acetyltransferase binding to ORC1 (HBO1), a histone acetyltransferase, was recently identified as an oncoprotein; however, its role in bladder cancer remains unknown. In this study, we showed that HBO1 highly expressed at both the mRNA and protein levels cancer. expression associated with clinical features of human cancer, including tumor size ( P = 0.018) T 0.007) classifications. Patients higher had shorter recurrence‐free survival time, whereas patients lower better time....
Atypical chemokine receptors (ACRs), including CCX-CKR, DARC, and D6, have been reported to be involved in cancer invasion metastasis. The objective of this study was investigate the prognostic importance ACRs patients with cervical squamous cell carcinoma (CSCC).The expression three investigated by immunohistochemical (IHC) examination a total 317 specimens 40 normal tissues, 50 cases situ cervix (CIS), 227 CSCC immunohistochemistry.The rate DARC CCX-CKR CSCC, CIS, increased gradually...
Calcium activated chloride channel A4 (CLCA4), a tumor suppressor, was shown to contribute the progression of several human cancers, while its role in bladder carcinoma remains unclear. In this study, we showed CLCA4 expression down-regulated tissues and cells compared adjacent non-tumor normal urothelial cells. Low correlated with larger size, advanced stage, poor prognosis patients. Overexpression profoundly attenuated proliferation, growth, migratory invasive capabilities cancer cells,...
The β1,3-N-acetylglucosaminyltransferase-3 gene (B3GNT3) encodes a member of the B3GNT family that functions as backbone structure dimeric sialyl-Lewis A and is involved in L-selectin ligand biosynthesis, lymphocyte homing trafficking. B3GNT3 has been implicated an important element development certain cancers. However, characteristics progression cancer remain largely unknown. Thus, our study aimed to investigate expression pattern prognostic value patients with early-stage cervical...
C14ORF166 (chromosome 14 open reading frame 166) is a transcriptional repressor related to the regulation of centrosome architecture. However, role in development and progression cancer remains largely unknown. The aim this study was investigate expression clinicopathological significance cervical cancer. analyzed using quantitative real-time PCR (RT-PCR) Western blotting cell lines eight paired samples adjacent normal tissues. Immunohistochemistry used analyze protein 148...
R-spondin 3 (RSPO3) is a secreted protein that associates directly with Wnt/β-catenin signaling. However, its functional contribution and prognostic value in human bladder cancer remain unclear. Here, we showed RSPO3 upregulated tissues cells, high expression of correlates advanced clinicopathological features, poor prognosis disease progression patients. Furthermore, observed ectopic or knockdown profoundly promoted inhibited, respectively, the invasive ability cells. Mechanistically, via...
Glutathione (GSH)-mediated drug resistance can strongly weaken the therapeutic efficiency of platinum(<sc>ii</sc>).
This study aimed to validate the value of urothelial stem cell (USC) markers ΔNp63, integrin β4, CD47, and CD44v6 in predicting prognosis non-muscle invasive bladder cancer (NMIBC) located different anatomic regions bladder.The reviewed clinicopathologic data 169 patients with NMIBC. Using real-time PCR immunohistochemistry, expression archived specimens NMIBC were validated. Kaplan-Meier analysis Cox proportional hazards model used assess prognostic impact USC for recurrent-free survival...
Arsenic is a common environmental toxicant. Long-term arsenic exposure can induce various types of liver injury, but the underlying mechanism remains unclear, so effective prevention and treatment measures are unknown. This study aims to explore arsenic-induced rat injury based on histone H3K18 acetylation-dependent antioxidant pathway identify role medicinal edible resource, Rosa roxburghii Tratt juice, in combating it. Hepatic steatosis inflammatory cell infiltration were observed rats...
Combined chemotherapeutic drug and protein has been a widely employed strategy for tumor treatment. To realize both accumulation deep penetration drugs with different pharmacokinetics, we propose structure-transformable, thermo-pH dual responsive co-delivery system to co-load granzyme B/docetaxel (GrB/DTX).Thermo-sensitive hydrogels based on diblock copolymers (mPEG-b-PELG) were synthesized through ring opening polymerization. GrB/DTX mini micelles (GDM) was developed by co-loading these two...
Photocatalytic water-splitting employing the Z-scheme semiconductor systems mimicking natural photosynthesis is regarded as a promising way to achieve efficient soalr-to-H2 conversion. Nevertheless, it still remains big challenge design high-performance direct photocatalysts without use of noble metals electron mediators. Herein, unique Cd0.5Zn0.5S/WO3-x heterojunction was constructed for first time, which consisted smaller O-vacancy-decorated WO3-x nanocrystals anchoring on Cd0.5Zn0.5S with...
Renal collecting duct carcinoma (CDC) is a rare and aggressive type of renal cell cancer (RCC), which difficult to confirm before surgery. We present case CDC presenting hypovascular mass on CTA deteriorated function the affected kidney single photon emission computed tomography (SPECT), are different from most common RCC, clear RCC. Considering these findings, it would be worthwhile investigating role SPECT in diagnosis.
In a previous work researchers found that fluorinated acrylate (PHFDA)/styrene (PSt)/ sulfonated styrene (S) copolymer can enhance the viscosity of carbon dioxide (CO 2 ) by factors greater than 100 at concentrations 5 wt %. To further improve efficiency this copolymer, we apply dissipative particle dynamics (DPD) method to investigate link between molecular structure and solution rheology. Results show molecules combine with each other create self-assembly structures, which greatly thicken...
Abstract Technique modifications that aim to improve ergonomics of the surgical procedure without repositioning upper tract urothelial carcinoma patients remain a challenge urologists. We offer novel technique perform intraperitoneal laparoscopic single-site radical nephroureterectomy and pelvic lymph nodes dissection/retroperitoneal dissection in supine position. Our is feasible offers significant improvement operative efficiency, particularly with locally advanced disease.
To evaluate the safety and feasibility of intraperitoneal laparoscopic surgery in Trendelenburg position (ILSTP) for pyelolithotomy, pyeloplasty, heminephrectomy patients with horseshoe kidneys (HSKs). Between March 2021 2024, three HSKs underwent ILSSP. Of these patients, two pelvi-ureteric junction obstruction recurrent kidney stones pyelolithotomy one symptomatic nonfunctioning left moiety a HSK was managed heminephrectomy. Mean operating time 114 ± 64.8 (44–172) min, estimated blood loss...