A5046672722- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- melanin and skin pigmentation
- Hair Growth and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Gene expression and cancer classification
- RNA regulation and disease
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Respiratory Support and Mechanisms
- DNA Repair Mechanisms
- Extracellular vesicles in disease
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Exercise and Physiological Responses
- Neuroscience of respiration and sleep
- Psoriasis: Treatment and Pathogenesis
Tecnológico de Monterrey
2012-2024
Gazi University
2023-2024
The University of Texas Health Science Center at Houston
2015-2021
Brown Foundation
2015-2021
Departamento de Salud
2019
In-Q-Tel
2018
University of Birmingham
2012
Androgenetic alopecia is a highly prevalent condition mainly affecting men. This complex trait related to aging and genetics; however, multiple other factors, for example, lifestyle, are also involved. Despite its prevalence, the underlying biology of androgenetic remains elusive, thus advances in treatment have been hindered. Herein, we review functional anatomy hair follicles cell signaling events that play role follicle cycling. We discuss pathology known molecular mechanisms this...
Long non-coding RNAs (lncRNAs) (> 200 bp) play crucial roles in transcriptional regulation during numerous biological processes. However, it is challenging to comprehensively identify lncRNAs, because they are often expressed at low levels and with more cell-type specificity than protein-coding genes. In the present study, we performed ab initio transcriptome reconstruction using eight purified cell populations from mouse cortex detected 5000 lncRNAs. Predicting functions of lncRNAs specific...
Abstract Spinal cord injury (SCI) remains one of the most debilitating neurological disorders and majority SCI patients are in chronic phase. Previous studies have usually focused on few genes pathways at a time. In particular, biological roles long non-coding RNAs (lncRNAs) never been characterized SCI. Our study is first to comprehensively investigate alterations expression both coding sub-chronic stages using RNA-Sequencing. Through pathway analysis network construction, functions...
Recent studies have revealed the heterogeneous nature of astrocytes; however, how diverse constituents astrocyte-lineage cells are regulated in adult spinal cord after injury and contribute to regeneration remains elusive. We perform single-cell RNA sequencing GFAP-expressing from sub-chronic models identify compare with subpopulations acute-stage data. find distinct functional enrichment their identities defined by subpopulation-specific transcription factors regulons. Immunohistochemistry,...
Adipose-derived stem cells (ADSCs) are a heterogeneous cell population that may be enriched by positive selection with antibodies against the low-affinity nerve growth factor receptor (LNGFR or CD271), yielding selective universe higher proliferation and differentiation potential. This paper addresses need for determining quantity of ADSCs CD271 its correlation donor's age. Mononuclear were harvested from lower backs 35 female donors purified using magnetic beads. Multipotency capacity was...
Abstract Currently, there are no effective treatments for glioma or neurodegenerative diseases because of, in part, our limited understanding of the pathophysiology and cellular heterogeneity these diseases. Mounting evidence suggests that astrocytes play an active role pathogenesis by contributing to a diverse range pathophysiological states. In previous study, five molecularly distinct astrocyte subpopulations from three different brain regions were identified. To further delineate...
Spinal cord injury (SCI) is one of the most devastating neural injuries without effective therapeutic solutions. Astrocytes are predominant component scar. Understanding complex contributions reactive astrocytes to SCI pathophysiologies fundamentally important for developing strategies. We have studied molecular changes in environment and astrocyte-specific responses by astrocyte purification from injured spinal cords acute chronic stages. In addition protein-coding genes, we systematically...
Chromatin architecture influences transcription by modulating the physical access of regulatory factors to DNA, playing fundamental roles in cell identity. Studies on dopaminergic differentiation have identified coding genes, but relationship with non-coding genes or chromatin accessibility remains elusive. Using RNA-Seq and ATAC-Seq we profiled differentially expressed transcripts open regions during early neuron differentiation. Hierarchical clustering resulted 6 groups unique...
Abstract Background Oligodendrocytes, responsible for axon ensheathment, are critical central nervous system (CNS) development, function, and diseases. OLIG2 is an important transcription factor (TF) that acts during oligodendrocyte development performs distinct functions at different stages. Previous studies have shown lncRNAs (long non-coding RNAs; > 200 bp) but their roles not been systematically characterized regulation yet clear. Results We performed integrated study of genome-wide...
Abstract Summary: The analysis of biological networks has become essential to study functional genomic data. Compadre is a tool estimate pathway/gene sets activity indexes using sub-matrix decompositions for analyses. pipeline also includes one the direct uses detect altered gene sets. For this, expression set decomposed into components, which are used test differences between groups samples. This procedure performed with and without differentially expressed genes decrease false calls....
Hyperoxia−hypoxia exposure is a proposed cause of alveolar developmental arrest in bronchopulmonary dysplasia preterm infants, where mitochondrial reactive oxygen species and oxidative stress vulnerability are increased. The aryl hydrocarbon receptor (AhR) one the main activators antioxidant enzyme system that protects tissues systems from damage. present study aimed to determine if activation AhR signaling pathway by prenatal administration indole-3-carbinol (I3C) rat pups...
We integrated datasets from transcriptomic, proteomic, epigenomic, and protein–protein interaction levels to build a global regulatory network better characterize the mechanisms underlying HSPCs self-renewal.
<h3>Background:</h3> Vascular calcification is a commonly occurring entity in large vessel vasculitides and associated with increased cardiovascular morbidity/mortality [1].<b></b> <h3>Objectives:</h3> The present study aims to determine the frequency of vascular Takayasu arteritis (TA) risk factors for it evaluate its relation atherosclerotic predictors such as left ventricular mass index (LMVI) carotid intima-media thickness (CIMT). <h3>Methods:</h3> A cross-sectional was conducted...
<h3>Background:</h3> Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) constitutes a diverse group of diseases characterized by inflammatory damage to small medium-sized vessels, leading organ and tissue impairment. Along with pulmonary renal, upper airway involvement is common feature, especially for granulomatosis polyangiitis. The Sinonasal Outcome Test 22 (SNOT-22) 22-item questionnaire that combines both nasal general health symptoms, providing quantitative...
In mammalian cells, gene transcription is regulated in a cell type specific manner by the interactions of transcriptional factors with genomic DNA. Lineage-specific are considered to play essential roles specification and differentiation during development. ChIP coupled high-throughput DNA sequencing (ChIP-seq) widely used analyze genome-wide binding sites (or its associated complex) However, large number cells required for one standard reaction, which makes it difficult study limited...
<h3>Background</h3> Following the failure of initial biological treatment in spondyloarthritis, switching to an alternative drug is possible. However, data regarding choice limited. ASAS/EULAR guideline on axial spondyloarthritis does not make a distinction between TNFi, IL-17i or JAKi, with certain precautions JAKi [1]. On other hand, ACR/SAA/SPARTAN recommends over different TNFi primary failure, based assumption that TNF key inflammatory mediator these patients [2]. <h3>Objectives</h3>...