A5079914187- Estrogen and related hormone effects
- RNA Research and Splicing
- Adenosine and Purinergic Signaling
- Genomics and Chromatin Dynamics
- Neurological disorders and treatments
- Cytokine Signaling Pathways and Interactions
- Pluripotent Stem Cells Research
- Gastrointestinal motility and disorders
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- NF-κB Signaling Pathways
- Inflammatory Bowel Disease
- Tannin, Tannase and Anticancer Activities
- Anesthesia and Neurotoxicity Research
- Nerve injury and regeneration
- Histone Deacetylase Inhibitors Research
- Microscopic Colitis
- Vitamin D Research Studies
- Genomics, phytochemicals, and oxidative stress
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Fluoride Effects and Removal
- interferon and immune responses
- PARP inhibition in cancer therapy
- Click Chemistry and Applications
Autonomous University of Aguascalientes
2020-2025
Tecnológico de Monterrey
2020-2023
Universidad Nacional Autónoma de México
2013-2020
Instituto Nacional de Cancerología
2019
The estrogen receptor alpha (ERα) is a ligand-activated transcription factor whose activity modulated by its interaction with multiple protein complexes. In this work, we have identified the interferon inducible 27 (IFI27/ISG12) as novel ERα-associated protein. IFI27/ISG12 regulated and estradiol overexpression associated to reduced overall survival in ER+ breast cancer patients but function mammary gland tissue remains elusive. study showed that of cells attenuates ERα transactivation...
Chromatin architecture influences transcription by modulating the physical access of regulatory factors to DNA, playing fundamental roles in cell identity. Studies on dopaminergic differentiation have identified coding genes, but relationship with non-coding genes or chromatin accessibility remains elusive. Using RNA-Seq and ATAC-Seq we profiled differentially expressed transcripts open regions during early neuron differentiation. Hierarchical clustering resulted 6 groups unique...
Previous studies have demonstrated that acute colonic inflammation leads to an increase in dorsal root ganglia (DRG) neuronal excitability. However, the signaling elements implicated this hyperexcitability yet be fully unraveled. Extracellular adenosine 5’-triphosphate (ATP) is a well-recognized sensory molecule enhances nociceptive response after through activation of P2X3 receptors, which are expressed mainly by peripheral neurons. The aim study continue investigating how affects...
Estrogen receptor α (ERα) mediates the effects of 17β-estradiol (E2) in normal mammary gland, and it is a key participant breast cancer tumor development. ERα transactivation activity mediated by synergistic interaction two domains designated AF1 AF2. The function AF2 to recruit coactivator corepressor proteins that allow oscillate between roles transcriptional activator repressor. In contrast, mechanism responsible for AF-1 not completely understood. this study, we identified...
The estrogen receptor alpha (ERα) is a ligand-activated transcription factor that possesses two activating domains designated AF-1 and AF-2 mediate its transcriptional activity. role of to recruit coregulator protein complexes capable modifying chromatin condensation status. In contrast, the mechanism responsible for ligand-independent activity synergistic functional interaction with unclear. this study, we have identified Na+/H+ Exchanger RegulatoryFactor 2 (NHERF2) as an ERα-associated...
Tristetraprolin (TTP) is a 34-kDa, zinc finger-containing factor that in mammalian cells acts as tumor suppressor protein through two different mechanisms. In the cytoplasm TTP promotes decay of hundreds mRNAs encoding cell factors involved inflammation, tissue invasion, and metastasis. nucleus has been identified transcriptional corepressor estrogen receptor alpha (ERα), which associated to development progression majority breast cancer tumors. this work we report nuclear modulates...
Human embryonic stem cells (hESCs) differentiate into specialized cells, including midbrain dopaminergic neurons (DANs), and Non-human primates (NHPs) injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine develop some alterations observed in Parkinson's disease (PD) patients. Here, we obtained well-characterized DANs from hESCs transplanted them two parkinsonian monkeys to assess their behavioral imaging changes. expressed markers, generated action potentials, released dopamine (DA)...
Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. (GC)-dependent protection against tumor necrosis factor (TNF)-induced death well characterized MCF7 luminal A cells. The GR activates a variety of protective mechanisms, such as inhibitors apoptosis proteins (IAPs). However, the relative contribution GR-dependent expression IAPs not, to our knowledge, evaluated.MCF7 cells were used for all experiments. was activated cortisol (CORT) or...
Colorectal cancer (CRC) is the third most common type of worldwide. Its treatment options have had a limited impact on remission prognosis. Therefore, there an ongoing need to discover novel anti-cancer agents. Medicinal plants gained recognition as source bioactive compounds. Recently, ethanolic extract
Human embryonic stem cells (hESCs) differentiate into specialized cells, including midbrain dopaminergic neurons (DAN). Non-human primates (NHPs) injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine develop some alterations observed in Parkinson’s disease (PD) patients. We obtained DAN from hESCs and confirmed that they express markers, generate action potentials, release dopamine (DA) vitro . were transplanted bilaterally the putamen of parkinsonian NHPs. After grafting, animals...