A5078719266- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- Parkinson's Disease Mechanisms and Treatments
- Motor Control and Adaptation
- Neurobiology and Insect Physiology Research
- Nerve injury and regeneration
- CRISPR and Genetic Engineering
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Hemispheric Asymmetry in Neuroscience
- RNA regulation and disease
- Advanced Neuroimaging Techniques and Applications
- Visual perception and processing mechanisms
- Collagen: Extraction and Characterization
- Facial Nerve Paralysis Treatment and Research
- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Action Observation and Synchronization
- Amphibian and Reptile Biology
- Nuclear Receptors and Signaling
- Neuroscience, Education and Cognitive Function
- Primate Behavior and Ecology
- Sport Psychology and Performance
Universidad Nacional Autónoma de México
2014-2024
Instituto Nacional de Neurología y Neurocirugía
2014-2023
Abstract Gender differences have been shown across many domains, and motor skills are no exception. One of the most robust findings is a significant sex difference in throwing accuracy, which reflects advantage men targeting abilities. However, little known about basis this difference. To try to dissect possible mechanisms involved difference, here we tested for gender variations prism adaptation task. We 154 subjects visuomotor task that discriminates between performance, negative...
Abstract Visuomotor adaptation is often driven by error‐based ( EB ) learning in which signed errors update motor commands. There are, however, visuomotor tasks where are unavailable or cannot be mapped onto appropriate command changes, rendering ineffective; and yet, healthy subjects can learn these learning‐free conditions. While depends on cerebellar integrity, the neural bases of ‐independent poorly understood. As basal ganglia involved mechanisms that independent error feedback, here we...
Cell therapy in experimental models of Parkinson's disease replaces the lost dopamine neurons (DAN), but we still need improved methods to guide dopaminergic axons (DAx) grafted make proper connections. The protein Semaphorin 3C (Sema3C) attracts DAN and enhances their growth. In this work, show that hydrogel PuraMatrix, a self-assembling peptide-based matrix, incorporates Sema3C releases it steadily during 4 weeks. We also tested if hydrogel-delivered DAx using system rat midbrain explants...
Background Previous studies of SCA2 have revealed significant degeneration white matter tracts in cerebellar and cerebral regions. The motor deficit these patients may be attributable to the degradation projection fibers associated with underlying neurodegenerative process. However, this relationship remains unclear. Statistical analysis diffusion tensor imaging enables an unbiased whole-brain quantitative comparison proprieties vivo. Methods Fourteen genetically confirmed aged-matched...
Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant inherited neurodegenerative disorder. Several post-mortem and imaging studies have shown cerebellar brainstem atrophy. A number of used volumetric regional information to investigate the relationship between neurodegeneration severity. However, analysis can obscure specific location in which degenerative process affecting brain tissue, be crucial for development new target treatments this disease. Here...
Parkinson`s disease (PD) is the second most prevalent neurodegenerative disease, and different gene therapy strategies have been used as experimental treatments. As a proof-of-concept for treatment of PD, we SAM, CRISPR activation system, to activate endogenous tyrosine hydroxylase (th) astrocytes produce dopamine (DA) in striatum 6-OHDA-lesioned rats. Potential sgRNAs within rat th promoter region were tested, expression Th protein was determined C6 glial cell line. Employing...
Abstract Objectives: The aim of this study was to explore the relationship between cognitive and white matter deterioration in a group participants with spinocerebellar ataxia type 2 (SCA2). Methods: Fourteen genetically confirmed SCA2 14 aged-matched controls participated study. Diffusion tensor imaging tract-based spatial statistics were performed analyze structural integrity. Significant differences mean diffusivity correlated deficits. Results: Our analysis revealed higher cerebellar...
Huntington's disease (HD) is an inherited neurodegenerative with clinical manifestations that involve motor, cognitive and psychiatric deficits. Cross-sectional magnetic resonance imaging (MRI) studies have described the main cortical subcortical macrostructural atrophy of HD. However, longitudinal characterizing progressive are lacking. This study aimed to describe gray matter using complementary volumetric surface-based MRI analyses in a cohort seventeen early HD patients cross-sectional...
Human embryonic stem cells (hESCs) differentiate into specialized cells, including midbrain dopaminergic neurons (DANs), and Non-human primates (NHPs) injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine develop some alterations observed in Parkinson's disease (PD) patients. Here, we obtained well-characterized DANs from hESCs transplanted them two parkinsonian monkeys to assess their behavioral imaging changes. expressed markers, generated action potentials, released dopamine (DA)...
Information about the world is often encoded in brain as topographic maps. These internal representations are not always static but can have a dynamic nature, allowing for constant adjustments that depend on factors like experience or injury. Recently, it has been shown areas involved visuomotor transformations also show topographical organization. findings suggest could be possible to observe plastic modifications specific parts of representation response local perturbation affects only...
Parkinson's disease is a neurodegenerative disease, resulting from deterioration of the substantia nigra which in turn leads to decrease dopamine levels striatum. Clinically syndrome characterized by motor alterations that are treated oral administration levodopa. However, this treatment typically loses efficacy over time and therefore new treatments procure steady long term supplement needed. Here we tested expression tyrosine hydroxilase (TH) transgene...
Huntington's disease (HD) patients show alterations in decision making tasks. However, it is still uncertain if these deficits are due to poor judgment regarding risky situations, or impulse control deficits.To elucidate whether decision-making related genuine risk behavior test between two alternative possibilities, we evaluated the performance of 19 prodromal HD and matched healthy controls Cambridge Gambling Task (CGT). This task assesses while dissociating risk-taking behaviors...
The ability to inhibit automatic versus voluntary saccade commands in demanding situations can be impaired neurodegenerative diseases such as Huntington's disease (HD). These deficits could result from disruptions the interaction between basal ganglia and control system. To investigate oculomotor related cortico-basal circuitry, we evaluated early HD patients using an interleaved pro- anti-saccade task that requires flexible executive generate either response (look at a peripheral visual...
Huntington’s Disease (HD) is an autosomal neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. Cognitive impairment develops gradually in HD patients, progressing later into a severe cognitive dysfunction. The Montreal Assessment (MoCA) brief screening test commonly employed to detect mild impairment, which has also been useful assess decline patients. However, the relationship between MoCA performance brain structural integrity patients remains unclear....
Abstract Parkinson`s disease (PD) is the second most prevalent neurodegenerative disease, and different gene therapy strategies have been used as experimental treatments. As a proof of concept for treatment PD, we SAM, CRISPR activation system, to activate endogenous tyrosine hydroxylase astrocytes produce dopamine (DA) in striatum 6-OHDA-lesioned rats. Potential sgRNAs within rat th promotor region were tested, expression Th protein was determined C6 glial cell line. Employing...
Introduction Early Huntington’s disease (HD) patients begin to show planning deficits even before motor alterations start manifest. Generally, ability is associated with the functioning of anterior brain areas such as medial prefrontal cortex. However, early HD neuropathology involves significant atrophy in occipital and parietal cortex, suggesting that more posterior regions could also be involved these deficits. Objective To identify at an clinical stage. Materials methods Twenty-two...