A5081821572- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Motor Control and Adaptation
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Visual perception and processing mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Tactile and Sensory Interactions
- Neural and Behavioral Psychology Studies
- Neuroendocrine regulation and behavior
- Nerve injury and regeneration
- Biochemical Analysis and Sensing Techniques
- Action Observation and Synchronization
- EEG and Brain-Computer Interfaces
- Vestibular and auditory disorders
- Neurobiology and Insect Physiology Research
- Neuroscience of respiration and sleep
- Traumatic Brain Injury Research
Universidad Nacional Autónoma de México
2016-2025
Universidad Veracruzana
2015-2025
Universidad Autónoma de la Ciudad de México
2020
Universidad Americana de Morelos
2017
Queen's University
2016
Institut des Sciences Cognitives Marc Jeannerod
2015
Universidad de Xalapa
2015
GTx (United States)
2014
Universidad del Distrito Federal
2013
Colciencias
2012
Visual habit formation in monkeys, assessed by concurrent visual discrimination learning with 24-h intertrial intervals (ITI), was found earlier to be impaired removal of the inferior temporal area (TE) but not either medial lobe or prefrontal convexity, two TE's major projection targets. To assess role this form another pair structures which TE projects, namely rostral portion tail caudate nucleus and overlying ventrocaudal putamen, we injected a neurotoxin into neostriatal region several...
Posterior parietal cortex (PPC) participates in the planning of visuospatial behaviors, including reach movements, gaze-centered coordinates. It is not known if these representations encode visual goal retinal coordinates, or movement direction relative to gaze. Here, by dissociating intrinsic stimulus from extrinsic movement, we show that PPC employs a code. Using delayed pointing and event-related functional magnetic resonance imaging, identified cluster regions whose activity was...
Prism adaptation, a form of procedural learning, is phenomenon in which the motor system adapts to new visuospatial coordinates imposed by prisms that displace visual field. Once are withdrawn, degree and strength adaptation can be measured spatial deviation actions direction opposite displacement prisms, known as aftereffect. This study was designed define variables affect acquisition retention Subjects were required throw balls target front them before, during, after lateral field with...
Abstract Gender differences have been shown across many domains, and motor skills are no exception. One of the most robust findings is a significant sex difference in throwing accuracy, which reflects advantage men targeting abilities. However, little known about basis this difference. To try to dissect possible mechanisms involved difference, here we tested for gender variations prism adaptation task. We 154 subjects visuomotor task that discriminates between performance, negative...
Amyotrophic lateral sclerosis (ALS) is characterized by degeneration of upper and lower motor neurons, resulting in progressive weakness muscle atrophy. Recent studies suggest that nondemented ALS patients can show selective cognitive impairments, predominantly executive dysfunction, but little known about the neural basis these impairments. Oculomotor have described deficits antisaccade execution, which requires implementation a task set includes inhibition automatic responses followed...
Olfactory deficits are present in many neurodegenerative diseases. It is not known, however, whether the olfactory deterioration caused by a common neural deficit, or it unique to each disease. We report here effect of degeneration different brain structures on impairment Huntington's disease as determined voxel-based morphometric analysis. The with greatest deficit were entorhinal cortex, thalamus, parahippocampal gyrus, and caudate nucleus. Although various neuroimaging studies have shown...
Abstract Visuomotor adaptation is often driven by error‐based ( EB ) learning in which signed errors update motor commands. There are, however, visuomotor tasks where are unavailable or cannot be mapped onto appropriate command changes, rendering ineffective; and yet, healthy subjects can learn these learning‐free conditions. While depends on cerebellar integrity, the neural bases of ‐independent poorly understood. As basal ganglia involved mechanisms that independent error feedback, here we...
ABSTRACT Spinocerebellar ataxia type 7 (SCA7) is an autosomal‐dominant neurodegenerative disorder characterized by progressive and retinal dystrophy. It caused a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration region‐specific neocortical atrophy SCA7 patients. However, impact of neurodegeneration on functional integration remaining tissue still unknown. The aim this study was to examine connectivity abnormalities areas with...
Abstract Background Several neuropathological studies in spinocerebellar ataxia type 2 (SCA2) have revealed significant atrophy of the cerebellum, brainstem, sensorimotor cortex, and several regions frontal lobe. However, impact neurodegeneration on functional integration remaining tissue is unknown. To analyze clinical these changes, we correlated abnormal connectivity found SCA2 patients with their scores scales. obtain followed two approaches. In one used areas cerebellar gray matter as...
Superficial white matter provides extensive cortico-cortical connections. This tractography study aimed to assess the diffusion characteristics of superficial tracts in Alzheimer's disease.Diffusion tensor 3T magnetic resonance imaging scans were acquired 24 controls and 16 participants with disease. Neuropsychological test scores available some participants. Tractography was performed by Fiber Assignment Continuous Tracking (FACT) method. The manually segmented divided into frontal,...
Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative diseases that selectively affect vulnerable neuronal populations in the cerebellum and other subcortical regions. While previous studies have reported subtype differences absolute amount degeneration specific regions interest, they failed to account for two important factors. First, did not control overall severity pattern, second, fully characterize spatial pattern each SCA subtype. Here, we provide systematic...