A5047036692- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Nerve injury and regeneration
- Eating Disorders and Behaviors
- Hemodynamic Monitoring and Therapy
- Spinal Cord Injury Research
- Autism Spectrum Disorder Research
- Impact of Technology on Adolescents
- Apelin-related biomedical research
- High Altitude and Hypoxia
- Infant Development and Preterm Care
- Children's Physical and Motor Development
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Neuroscience of respiration and sleep
- Child Development and Digital Technology
- Exercise and Physiological Responses
- Physical Activity and Health
- Infrared Thermography in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dietary Effects on Health
- Cardiovascular Syncope and Autonomic Disorders
- Transcranial Magnetic Stimulation Studies
University of British Columbia
2019-2025
McMaster University
2020-2025
Queen's University
2011-2021
Okanagan University College
2019-2021
Children's Hospital of Eastern Ontario
2018-2020
Agricultural Research Institute of Ontario
2018
Deaconess Clinic
2013
Abstract Pre-clinical and cell culture evidence supports the role of ketone beta-hydroxybutyrate (BHB) as an immunomodulatory molecule that may inhibit inflammatory signalling involved in several chronic diseases such type 2 diabetes (T2D), but studies humans are lacking. Therefore, we investigated anti-inflammatory effect BHB across three clinical trials. To investigate if suppressed pro-inflammatory cytokine secretion, treated LPS-stimulated leukocytes from overnight-fasted adults at risk...
The objective of this study was to examine individual and concurrent associations between meeting the Canadian 24-Hour Movement Guidelines for Children Youth (9-11 hours sleep per night, ≤2 recreational screen time (ST) day, at least 60 minutes moderate vigorous physical activity day) dimensions impulsivity.
Abstract Context Postprandial hyperglycemia increases systemic inflammation and is a risk factor for cardiovascular disease. A ketone monoester (KME) drink containing β-hydroxybutyrate (β-OHB) rapidly lowers plasma glucose, which may be strategy protecting against postprandial hyperglycemia. Objective We hypothesized that KME would attenuate 2-hour lower inflammation, improve vascular function in adults with obesity. Methods In randomized crossover design, 14 participants obesity (age = 56 ±...
Resistance exercise is an efficacious stimulus for improving cognitive function in older adults, which may be mediated by the upregulation of blood-borne neurotrophic growth factors (NTFs) like brain-derived factor (BDNF) and insulin-like factor-1 (IGF-1). However, NTF response to resistance training adults poorly understood. Therefore, purpose this study was characterize timing magnitude following acute bout before after 8 weeks training. Ten cognitively normal, (ages 60-77 years, five men)...
Abstract Adults with obesity are at increased risk of neurocognitive impairments, partly as a result reduced cerebral blood flow and brain‐derived neurotrophic factor (BDNF). Ketone supplements containing β‐hydroxybutyrate (β‐OHB) purported therapeutic strategy for improving brain health in at‐risk populations. We tested the hypothesis that short‐term β‐OHB supplementation will elevate BDNF, well improve cognition adults obesity. In placebo‐controlled double‐blind, cross‐over design, 14 (10...
Brain-derived neurotrophic factor (BDNF) gene expression was measured in human skeletal muscle following 3 intensities of exercise and a 48-h fast. No change BDNF mRNA observed exercise, while fasting upregulated by ∼3.5-fold. These changes were dissociated from peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) (+2- to 15-fold) (∼–25%). results challenge our understanding the response energetic stress highlight importance future work this area.
This study investigated the impact of exercise training on interindividual variability and response rates in body composition cardiometabolic outcomes adolescents with obesity. Postpubertal males females (n = 143) were randomly assigned to 6 months a diet-only control or aerobic, resistance, combined training. Body indices percentages fat mass lean waist circumference. Biomarkers health systolic blood pressure plasma fasting glucose, triglycerides, high-density lipoprotein cholesterol....
Introduction People with type 2 diabetes (T2D) have a greater risk of developing neurodegenerative diseases, like Alzheimer's disease, in later life. Exogenous ketone supplements containing the body β-hydroxybutyrate (β-OHB) may be strategy to protect brain as β-OHB can support cerebral metabolism and promote neuronal plasticity via expression brain-derived neurotrophic factor (BDNF). Methods Results Parallel human (ClinicalTrials.gov ID NCT04194450, ClinicalTrials.gov NCT05155410) rodent...
Abstract Exogenous ketone monoester (KME) supplements rapidly increase plasma beta‐hydroxybutyrate (β‐OHB) and may impact cerebral blood flow (CBF). However, it is currently unknown how acute KME ingestion impacts resting CBF whether differences in dose have differential effects on regulation. The purpose of this study was to investigate the effect two separate doses young adults. On days a double‐blind, placebo‐controlled, cross‐over design, 20 participants (10 females; aged 23 ± 3 years)...
Abstract Objectives Sleep loss decreases working memory (WM) performance in young adults. The mechanisms that regulate WM during sleep are integrative and likely depend on the duration of perturbed sleep. aim this research was to investigate impact a single night partial restriction (PSR) WM, extent which factors such as cardiorespiratory fitness brain-derived neurotrophic factor (BDNF) influence following one PSR. Methods We measured after PSR twenty-two adults (n=13 females) with otherwise...
Obesity in youth increases the risk of type 2 diabetes (T2D), and both are factors for neurocognitive deficits. Exercise attenuates obesity T2D while improving cognitive function. In adults, these benefits associated with actions brain-derived neurotrophic factor (BDNF), a protein critical modulating neuroplasticity, glucose regulation, fat oxidation, appetite regulation adults. However, little research exists youth. This study examined associations between changes BDNF levels after 6 months...
Brain-derived neurotrophic factor (BDNF) is a major orchestrator of exercise-induced brain plasticity and circulating (peripheral) BDNF may have central effects. Approximately 99% platelet-bound, at rest ~30% platelets are stored in the spleen. Interestingly, forearm handgrip exercise significantly elevates sympathetic outflow has been shown to induce splenic constriction, suggesting that small muscle mass could stand as viable strategy for increasing BDNF; however, response currently...
Brain-derived neurotrophic factor (BDNF) is important for brain and metabolic function. Ingestion of a ketone monoester (KME) drink containing beta-hydroxybutyrate (β-OHB) attenuates hyperglycemia in humans increases neuronal BDNF rodents. Whether KME affects currently unknown. This study examined the effect ingestion before an oral glucose tolerance test (OGTT) on plasma normal-weight adults (NW) with obesity (OB).
Acute ingestion of the exogenous ketone monoester supplement [(R)-3-hydroxybutyl-(R)-3-hydroxybutyrate] lowers blood glucose, suggesting therapeutic potential in individuals with impaired glucose metabolism. However, it is unknown how acute or repeated ketones affects control type 2 diabetes (T2D). We conducted two randomized, counterbalanced, double-blind, placebo-controlled crossover trials to determine if