Alcohol consumption significantly impacts disease burden and has been linked to various diseases in observational studies. However, comprehensive meta-analyses using Mendelian randomization (MR) examine drinking patterns are limited. We aimed evaluate the health risks of alcohol use by integrating findings from MR A thorough search was conducted for studies focused on exposure. utilized two sets instrumental variables—alcohol problematic use—and summary statistics FinnGen consortium R9...

Abstract Abnormal accumulation of lipids has been highlighted in the progression clear cell renal carcinoma (ccRCC). However, underlying mechanism remains unclear. Emerging evidence suggests long noncoding RNAs (lncRNAs) participate regulation lipid metabolism. In this study, we found lncRNA COL18A1-AS1 was downregulated ccRCC and that higher expression indicated better prognosis. Decreased caused by DNA methylation at CpG islands within its promoter. Restoring epigenetically silenced...

By tracing the characteristic proton and carbon nuclear magnetic resonance signals of furan ring aldehyde group, four novel 5‐hydroxymethylfurfural derivatives, fusaroxysporins A‐D (1‐4), together with ten known compounds were obtained from marine fungus Fusarium oxysporum SP7. Their structures elucidated by comprehensive spectroscopic analysis. The possible biogenic synthesis pathways these speculated. Compound 1 showed moderate cytotoxic activity against human type II alveolar epithelial...

The autism spectrum disorders (ASD) comprise a broad group of behaviorally related neurodevelopmental affecting as many 1 in 68 children. hallmarks ASD consist impaired social and communication interactions, pronounced repetitive behaviors restricted patterns interests. Family, twin epidemiological studies suggest polygenetic epistatic susceptibility model involving the interaction genes; however, etiology is likely to be complex include both epigenetic environmental factors....

Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver cancer with poor prognosis. The gut microbiota has been linked to ICC, but evidence for causality lacking. Elucidating causal microbiota-ICC links could inform prevention and treatment strategies.We performed a bidirectional two-sample Mendelian randomization (MR) study investigate associations between ICC risk. Genome-wide significant single nucleotide polymorphisms (SNPs) associated abundances were utilized as instrumental...

Children with an anxious temperament (AT) are at a substantially increased risk to develop anxiety and depression. The young rhesus monkey is ideal for studying the origin of human AT because it shares humans genetic, neural, phenotypic underpinnings complex social emotional functioning. Heritability, functional imaging, gene expression studies in monkeys revealed that central nucleus amygdala (Ce) key environmentally sensitive substrate this phenotype. Because epigenetic marks (e.g., DNA...

Cholangiocarcinoma (CCA) is a highly malignant biliary tract cancer with poor prognosis. Previous studies have implicated the gut microbiota in CCA, but evidence for causal mechanisms lacking.

Renal cell carcinoma (RCC) is one of the most common malignant tumors urinary system and accounts for more than 90 % all renal tumors. Resistance to targeted therapy has emerged as a pivotal factor that contributes progressive deterioration patients with advanced RCC. Metabolic reprogramming hallmark tumorigenesis progression, an increasing body evidence indicating abnormal lipid metabolism plays crucial role in advancement clear carcinoma. Clarify precise mechanisms underlying drug...

Constructing a reliable and robust cobalt-based catalyst for hydrogen evolution via hydrolysis of sodium borohydride is appealing but challenging due to the deactivation caused by metal leaching re-oxidization metallic cobalt. A unique core-shell-structured coronavirus-like Co@C microsphere was prepared pyrolysis Co-MOF. This special had microporous carbon coating retain reduced state cobalt resist leaching. Furthermore, several nano-bumps grown discretely on surface afforded enriched active...

Abstract As the most prominent RNA modification, N6‐methyladenosine (m 6 A) participates in regulation of tumour initiation and progression. Circular RNAs (circRNAs) also play crucial roles ubiquitous life processes. Whether circRNAs are required for m A renal cell carcinoma (RCC) remains unclear. Meta‐analysis bioinformatics identified that IGF2BP3 was upregulated RCC indicated a worse prognosis. significantly promoted progression vitro vivo. Mechanistically, circRARS bound to KH1–KH2...

Abstract Obesity is a global health concern and independent risk factor for cancers including hepatocellular carcinoma (HCC). However, evidence on the causal links between obesity HCC limited inconclusive. This study aimed to investigate relationship obesity-related traits explore underlying mechanisms using bioinformatics approaches. Two-sample Mendelian randomization analysis was conducted leveraging publicly available genome-wide association summary data (body mass index, body fat...

Mouse knockouts of Cntnap2 show altered neurodevelopmental behavior, deficits in striatal GABAergic signaling, and a genome-wide disruption an environmentally sensitive DNA methylation modification (5-hydroxymethylcytosine [5hmC]) the orthologs significant number genes implicated human disorders. We tested adult heterozygous mice (Cntnap2+/-; lacking behavioral or neuropathological abnormalities) subjected to prenatal stress found that prenatally stressed Cntnap2+/- female repetitive...

Abstract Poorly identified tumor boundaries and nontargeted therapies lead to the high recurrence rates poor quality of life prostate cancer patients. Near-infrared-II (NIR-II) fluorescence imaging provides certain advantages, including resolution sensitive detection boundaries. Herein, a cyanine agent (CY7-4) with significantly greater affinity blood circulation time than indocyanine green was screened. By binding albumin, absorbance CY7-4 in an aqueous solution showed no effects from...

Alcoholic liver disease (ALD) significantly contributes to global morbidity and mortality. The role of inflammatory cytokines in alcohol-induced injury is pivotal yet not fully elucidated.

Abstract Existed classifications of congenital proximal radioulnar synostosis (PRUS) mainly focus on osseous changes and do not cover all types PRUS, ignoring the role developing status supinator. This study aims to explore correlation between supinator development radiographic deformity PRUS. Pediatric patients diagnosed with PRUS in two pediatric Orthopedic centers were evaluated retrospectively. MRI images their bilateral forearms (including normal ones) collected. The area supinator,...

Background For metastatic prostate cancer (mPCa), radical prostatectomy (RP) and radiation therapy (RT) may improve overall survival (OS) cancer-specific (CSS). Compared with RT, RP shows significant advantages in improving patient outcomes. External beam (EBRT) even slightly elevates CSM no statistical difference OS compared local treatment (NLT). Objective To evaluate CSS after (LT) (including RT) versus NLT mPCa. Design, setting, participants Within the Surveillance, Epidemiology End...

Displaced supracondylar femoral fractures (SFF) are difficult injuries to treat in children. Several techniques have been widely used but few studies compared the merits and drawbacks of each surgical intervention order analyze clinical values. The aim this study was (1) evaluate postoperative functional conditions after treatments with locking plate (LP) or external fixation (EF), (2) observe adverse events associated these two techniques, (3) value techniques.Twenty-eight patients less...

Kirschner-wire fixation (KF) and external (EF) for the treatment of displaced supracondylar femur fractures (SFFs) were demonstrated respectively in previous reports. However, there is no paucity convincing information on better options children. The aim this study was to show results KF EF paediatric SFFs according clinical radiological outcome.A retrospective analysis including 22 closed performed. A total 12 patients treated with KF, other ten EF. All followed up at least 24 months....

In recent years, a large number of genomic and epigenomic studies have been focusing on the integrative analysis multiple experimental datasets measured over observational units. The objectives such include not only inferring hidden state activity for each unit individual experiments, but also detecting highly associated clusters units based their inferred states. this paper, we develop MBASIC (Matrix Based Analysis State-space Inference Clustering) framework. consists two parts: state-space...

Abstract Supracondylar femoral fractures are uncommon in children, but may result various deformities. Though many approaches have been used to manage them, there is no literally approved standard yet. From 2015 2017, 12 young children at the average age of 2.5 years old (range 3.6–1.6) with displaced supracondylar were admitted our department and received closed reduction crossed Kirschner wire (K-wire) fixation as treatment. After surgeries, we performed follow-up every patient length 26...

The aim of this study was to evaluate the clinical and radiological outcomes complications external fixation use in treatment children with displaced supracondylar femoral fractures..In retrospective study, 14 (6 boys, 8 girls; mean age = 7.3 years; range 3.9 - 10.3 years) who underwent for a fracture from 2010 2017 were included. Their medical records reviewed general information surgery details. Postoperative information, such as time radiographic union, regain walking ability, Knee...