A5014945859- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- IL-33, ST2, and ILC Pathways
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Animal Nutrition and Physiology
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Diet, Metabolism, and Disease
- Probiotics and Fermented Foods
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Immune Cell Function and Interaction
- Renal cell carcinoma treatment
- Heavy Metal Exposure and Toxicity
- Immune Response and Inflammation
- Toxic Organic Pollutants Impact
- Cancer survivorship and care
- Inflammatory Biomarkers in Disease Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Research and Splicing
- Colorectal Cancer Screening and Detection
Nanjing Agricultural University
2018-2024
Hangzhou Seventh Peoples Hospital
2023-2024
Zhejiang University
2023-2024
Zhejiang Shuren University
2021-2024
Huazhong University of Science and Technology
2022-2024
Hubei Cancer Hospital
2022-2024
Central South University
2016-2018
Army Medical University
2013-2017
Daping Hospital
2017
Second Xiangya Hospital of Central South University
2016
Abstract Background and Aim Micro RNA s (mi s) are small noncoding molecules that control target gene expression implicated in the regulation of diverse cellular pathways. In our previous research, we have demonstrated mi R ‐224 was overexpressed liver cancer cells tissues, which an important factor cell migration invasion. This study aimed to further explore regulatory mechanism invasion cells. Methods A luciferase reporter assay used confirm HOXD 10 a direct ‐224. Quantitative reverse...
Abstract Questions Ecologists are increasingly interested in community‐level consequences of biotic interactions. However, studies have not considered that interactions might contrasting directions within communities, and indirect rarely quantified although they may influence outcomes. We tested the hypotheses species‐rich plant communities from intermediate severe environmental conditions: (1) direct facilitation by dominant functional groups is balanced negative among beneficiary species...
Growing evidence suggests that nutritional status and inflammation are associated with survival in various cancers. This study aimed to evaluate the prognostic value of index (PNI), geriatric risk (GNRI), systemic inflammatory indexes (neutrophil/lymphocyte ratio [NLR], monocyte/lymphocyte [MLR], platelet/lymphocyte [PLR]) patients stage IIB-III cervical cancer receiving radiotherapy.The ideal cutoff values for PNI, GNRI, NLR, MLR, PLR were 48.3, 97.04, 2.8, 0.41, 186.67, respectively. Low...
Estrogen receptor β (ERβ) and NOD-like family pyrin domain containing 6 (NLRP6) are highly expressed in intestinal tissues. Loss of ERβ NLRP6 exacerbate colitis mouse models; however, the underlying mechanisms incompletely understood. Here, we report that directly activates gene expression via binding to estrogen responsive element Nlrp6 promoter. also physically interacts with nucleotide-binding promotes inflammasome assembly. The ERβ-NLRP6 axis then multiple autophagy-related proteins,...
Pancreatic cancer is one of the principal causes tumor-related death worldwide. CXC chemokines, a subfamily functional chemotactic peptides, affect initiation tumor cells and clinical outcomes in several human malignant tumors. However, specific biological functions significance chemokines pancreatic have not been clarified.Bioinformatics analysis tools databases, including ONCOMINE, GEPIA2, Human Protein Atlas, DAVID, GeneMANIA, cBioPortal, STRING, DGidb, MethSurv, TRRUST, SurvExpress,...
Cholangiocarcinoma (CCA) is a highly malignant biliary tract cancer with poor prognosis. Previous studies have implicated the gut microbiota in CCA, but evidence for causal mechanisms lacking.
Metabolic-associated fatty liver disease (MAFLD) is currently one of the main causes chronic disease, but its potential mechanism remains unclear. This study proved that estrogen receptor α (ERα) could negatively control hepatocyte pyroptosis by inhibiting NOD-like family pyrin domain containing 3 (NLRP3) inflammasome activation, gasdermin D (GSDMD)-N generation, propidium iodide (PI) uptake, lactate dehydrogenase (LDH) release, and pro-inflammatory cytokine (IL-1β IL-18) release....
Hepatoid adenocarcinoma (HAC) of the lung (HAL) is a rare and aggressive extrahepatic with an unknown etiology unfavorable prognosis, which similar to pathophysiological characteristics hepatocellular carcinoma (HCC).We first presented 67-year-old patient diagnosed HAC in right middle lobe lung. Then, systematic literature search was performed for HAL cases recorded between 1990 2020 based on three databases. The clinicopathological features, therapeutic method, prognosis this disease were...
Objective This study aimed to perform an integrated pan-cancer analysis characterize the expression patterns, prognostic value, genetic alterations, and immunologic roles of transforming growth factor beta 1 (TGFB1) across diverse human cancer types. Methods Bioinformatics analyses were conducted using multiple public databases including The Cancer Genome Atlas, Genotype-Tissue Expression, Clinical Proteomic Tumor Analysis Consortium, TIMER2, GEPIA2, cBioPortal, StringDB, others....
Abstract Obesity is a global health concern and independent risk factor for cancers including hepatocellular carcinoma (HCC). However, evidence on the causal links between obesity HCC limited inconclusive. This study aimed to investigate relationship obesity-related traits explore underlying mechanisms using bioinformatics approaches. Two-sample Mendelian randomization analysis was conducted leveraging publicly available genome-wide association summary data (body mass index, body fat...
Background: Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and accompanied by a complex regulatory network. Increasing evidence suggests that an abnormal gene expression EZH2 associated with HCC progression. However, molecular mechanism which non-coding RNAs (ncRNAs) regulate remains elusive. Methods: The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) data were used to perform differential analysis prognostic analysis. We Encyclopedia RNA Interactomes...
Since the outbreak of COVID-19, widespread utilization disinfectants has led to a tremendous increase in generation disinfection byproducts worldwide. Bromoacetic acid (BAA), one common environment, triggered public concern because its adverse effects on urinary system mammals. Nevertheless, BAA-induced nephrotoxicity and potential mechanism birds still remains obscure. According detected content Taihu Lake Basin, model BAA exposure chicken was established at doses 0, 3, 300, 3000 μg/L for 4...
Malignant tumor is one of the most common diseases that seriously affect human health. The prior literature has reported biological function and potential therapeutic targets SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) as an oncogene. However, SETDB1 rarely been analyzed from a pan-cancer perspective.Bioinformatics analysis tools databases, including GeneCards, National Center for Biotechnology Information (NCBI), UniProt, Illustrator Biological Sequences (IBS), Human...