A5021850946- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Viral gastroenteritis research and epidemiology
- Inflammasome and immune disorders
- Virus-based gene therapy research
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- IL-33, ST2, and ILC Pathways
- Pharmacological Effects of Natural Compounds
- Mycotoxins in Agriculture and Food
- Immune Response and Inflammation
- Infectious Diseases and Tuberculosis
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Virology and Viral Diseases
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Pneumonia and Respiratory Infections
- Advanced Biosensing Techniques and Applications
Nanjing Agricultural University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Jiangxi University of Traditional Chinese Medicine
2022-2024
Shanghai Pulmonary Hospital
2007-2021
Tongji University
2013-2021
Shanghai Clinical Research Center
2021
Ribon Therapeutics (United States)
2021
Acorda Therapeutics (United States)
2021
Agios Pharmaceuticals (United States)
2021
Jiangsu Academy of Agricultural Sciences
2020
Somatic point mutations at a key arginine residue (R132) within the active site of metabolic enzyme isocitrate dehydrogenase 1 (IDH1) confer novel gain function in cancer cells, resulting production d-2-hydroxyglutarate (2-HG), an oncometabolite. Elevated 2-HG levels are implicated epigenetic alterations and impaired cellular differentiation. IDH1 have been described array hematologic malignancies solid tumors. Here, we report discovery AG-120 (ivosidenib), inhibitor mutant that exhibits...
H9N2 avian influenza virus (AIV) has an extended host range, but the molecular basis underlying AIV transmission to mammals remains unclear. We isolated more than 900 AIVs in our 3-year surveillance live bird markets China from 2009 2012. Thirty-seven representative isolates were selected for further detailed characterization. These categorized into 8 genotypes (B64 B71) and formed a distinct antigenic subgroup. Three belonging genotype B69, which is predominant circulating China, replicated...
Abstract In this study, the mitochondrial damage effect and mechanism of zearalenone (ZEA) in swine small intestine IPEC‐J2 cells vitro were comprehensively characterized. The analyses revealed that ZEA at high doses (8 7 μg/mL) can significantly increase P < 0.05 malondialdehyde levels decrease antioxidant enzymes activities after 48 h exposure. Meanwhile, reactive oxygen species (ROS) accumulation increased dose ZEA‐treated groups 2 treatment, but decreased due to ROS‐induced caused...
Metagenomic Next-Generation Sequencing (mNGS) has been applied as a novel method of detection pathogens for infectious diseases, but its value in the rapid diagnosis tuberculous meningitis(TBM)has not clarified based on large samples.A retrospective analysis was conducted 51 inpatients with suspected TBM who underwent mNGS and four other tests cerebrospinal fluid (CSF).Among included patients, 45 cases were diagnosed (38 definite, 5 probable, 2 possible) 6 non-TBM. Using final reference...
Disruption of intestinal homeostasis is an important event in the development inflammatory bowel disease (IBD), and genistein (GEN) a candidate medicine to prevent IBD. However, clinical application GEN restricted owing its low oral bioavailability. Herein, reactive oxygen species (ROS)-responsive nanomaterial (defined as GEN-NP2) containing superoxidase dismutase-mimetic temporally conjugated β-cyclodextrin 4-(hydroxymethyl)phenylboronic acid pinacol ester-modified was prepared. GEN-NP2...
Curcumin (CCM) has many potential uses in anticancer chemotherapy, but its low water solubility poses a major problem, preventing translation into clinical use. TPGS is water-soluble derivative of vitamin E that acts as surfactant with the ability to form micellar nanoparticles water. More importantly, potent antioxidant can neutralize intracellular reactive oxygen species (ROS). In this study, we solubilized CCM using thin-film rehydration prepare aqueous formulations containing at...
Abstract Fowl adenovirus serotype 4 (FAdV-4) is a non-enveloped double-stranded DNA virus with 43–45 kb genome. This characteristic makes it promising viral vector for expressing other antigens in developing multi-valent or multi-series vaccines the poultry industry. To create an easy-to-use reverse genetics system manipulating FAdV-4 genomic DNA, full-length infectious clone of was constructed using lambda Red-mediated recombination Escherichia coli DH10B. Viable viruses were successfully...
Abstract To establish an accurate, rapid, and a quantifiable method for the detection of newly emerged duck Tembusu virus (DTMUV) that recently caused widespread infectious disease in ducks China, we developed TaqMan-based real-time PCR assay by using E gene-specific primers TaqMan probe. This was 100 times more sensitive than conventional PCR. The reproducibility specificity were confirmed plasmids containing genes or RNAs DNAs extracted from well-known viruses causing diseases. reliability...
We aimed to identify the active ingredients and elucidate underlying mechanism of action Atractylodes lancea (Thunb.) DC (namely, Cangzhu) for treatment gouty arthritis (GA) based on network pharmacology methods. These findings are expected provide a theoretical basis clinical GA.We used monosodium urate (MSU)-induced GA rats as model test overall efficacy Cangzhu in vivo. Then, components decoction were analyzed identified, we screened their targets. The disease targets predicted by...
Gastric ulcer (GU) is one of the most commonly diagnosed diseases worldwide, threatening human health and seriously affecting quality life. Reports have shown that Chinese herbal medicine Sarcandra glabra (Thunb.) Nakai (SGN) can treat GU. However, its pharmacological effects deserve further validation; in addition, mechanism action unclear. An acute gastric (AGU) rat model induced by alcohol was used to evaluate gastroprotective effect SGN analysis histopathological changes stomach tissue...
Estrogen receptor β (ERβ) and NOD-like family pyrin domain containing 6 (NLRP6) are highly expressed in intestinal tissues. Loss of ERβ NLRP6 exacerbate colitis mouse models; however, the underlying mechanisms incompletely understood. Here, we report that directly activates gene expression via binding to estrogen responsive element Nlrp6 promoter. also physically interacts with nucleotide-binding promotes inflammasome assembly. The ERβ-NLRP6 axis then multiple autophagy-related proteins,...
An eco-friendly and efficient one-step approach for the synthesis of carbon quantum dots (CDs) that encapsulated molecularly imprinted fluorescence quenching particles (MIFQP) their application determination zearalenone (ZEA) in a cereal sample are described this study. CDs with high luminescence were first synthesized, then silica-based matrix through non-hydrolytic sol-gel process. The resulting ZEA-imprinted exhibited not only an excellent specific molecular recognition ZEA, but also good...
The aim of this study was to investigate the occurrence most common mycotoxins in commercial dry dog food using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Aflatoxin B1 (AFB1), aflatoxin G1 (AFG1), zearalenone (ZEN), deoxynivalenol (DON), T-2, beauvericin (BEA), citrinin (CIT), ochratoxin A (OTA), fumonisin (FB1) were included study. results showed that all these analytes could be found samples. Furthermore, only one sample free contamination. All other samples (96.9%)...