A5100783153- Immune Cell Function and Interaction
- interferon and immune responses
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Organ Transplantation Techniques and Outcomes
- Inflammasome and immune disorders
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Liver physiology and pathology
- Intestinal and Peritoneal Adhesions
- Eosinophilic Esophagitis
- Hernia repair and management
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Cancer Cells and Metastasis
- Cytokine Signaling Pathways and Interactions
- Biomarkers in Disease Mechanisms
- Stoma care and complications
- Microscopic Colitis
- Intestinal Malrotation and Obstruction Disorders
- Nitric Oxide and Endothelin Effects
Nanjing Drum Tower Hospital
2016-2025
Nanjing Medical University
2010-2024
Beijing Tongren Hospital
2023
Capital Medical University
2023
National Natural Science Foundation of China
2021
Southern Medical University
2021
Chinese People's Liberation Army
2021
Chinese PLA General Hospital
2021
Nanjing University
2012-2021
Military Hospital
2018
Peritoneal metastasis (PM) occurs frequently in patients with gastric cancer (GC) and confers poor survival. Lipid metabolism acts as a non-negligible regulator epithelial-mesenchymal transition (EMT), which is crucial for the of GC. As apolipoprotein C2 (APOC2) key activator lipoprotein lipase triglyceride metabolism, exact mechanism APOC2 remains largely unknown
Abstract Anoikis is a type of programmed cell death induced by detachment from the extracellular matrix. In cancer cells, anoikis resistance essential for survival in blood circulation and distant metastasis. However, mechanisms behind gastric remain largely unknown. Herein, we demonstrate that NADPH oxidase 4 (NOX4) expression reactive oxygen species (ROS) generation are upregulated suspension cultures compared with adherent cultures. Silencing NOX4 decreases ROS downregulates EGFR,...
Activation of simulator interferon genes (STING), which induces the production proinflammatory factors and immune effector cell activation, is considered a promising strategy for enhanced anti-cancer intervention. However, several obstacles prevent STING signaling in solid tumors, such as delivered molecules’ rapid degradation, restriction to tumor sites, insufficient intracellular concentrations, low responsivity. Well-designed, multifunctional nano-formulations have emerged optimized...
Laparoscopic common bile duct exploration (LCBDE) for stone can be carried out by either laparoscopic transcystic extraction (LTSE) or choledochotomy (LC). It remains unknown as to which approach is optimal management of gallbladder with stones (CBDS) in Chinese patients. From May 2000 February 2009, we prospective treated 346 consecutive patients and CBDS cholecystectomy LCBDE. Intraoperative findings, postoperative complications, hospital stay costs were analyzed. Because LCBDE failure,16...
G protein coupled estrogen receptor (GPER1) is a membrane receptor, belonging to the seven-transmembrane protein-coupled receptors family, and has important biological functions in cancer. However, functional role of GPER1 gastric cancer (GC) remain incompletely understood. In present study, we employed gene set enrichment analysis discovered that expression was concomitant with EMT process positively correlated activation PI3K/AKT pathway GC. Knockdown siRNA suppressed proliferation,...
Estrogen receptor β (ERβ) and NOD-like family pyrin domain containing 6 (NLRP6) are highly expressed in intestinal tissues. Loss of ERβ NLRP6 exacerbate colitis mouse models; however, the underlying mechanisms incompletely understood. Here, we report that directly activates gene expression via binding to estrogen responsive element Nlrp6 promoter. also physically interacts with nucleotide-binding promotes inflammasome assembly. The ERβ-NLRP6 axis then multiple autophagy-related proteins,...
Abstract Objective Personalized chemotherapy based on molecular biomarkers can maximize anticancer efficiency. We aim to investigate predictive capable of predicting response irinotecan-based treatment in gastric cancer. Methods examined gene expression APTX, BRCA1, ERCC1, ISG15, Topo1 and methylation SULF2 formalin-fixed paraffin-embedded cancer tissues from 175 patients evaluated the association between levels or status vitro sensitivity irinotecan. used multiple linear regression analysis...
Background: As the most predominant tumor-infiltrating immune cells, tumor-associated macrophages (TAMs) are associated with poor outcome in multiple solid cancers and play important roles cancer progression. Cancer stem cells (CSCs) may account for metastasis recurrence after therapy. However, association between TAMs CSCs is not clarified gastric (GC). The aim of present study was to evaluate effects on GC find out risk factors predict prognosis. Material methods: This included consecutive...
Wip1 is a serine/threonine protein phosphatase which plays critical role in neutrophil development and maturation. In the present study, we used neutrophildependent model of intestinal ischemia/reperfusion (I/R) injury to identify function under condition oxidative stress inflammation. Wip1- deficient mice displayed more severe I/R with increased infiltration neutrophils higher expression chemokines like CXCL-1, CXCL-2 CCL-2, as well inflammatory cytokine TNF-α IL-17. Studies Wip1KOa→WT full...