A5100411324- Lung Cancer Research Studies
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Kawasaki Disease and Coronary Complications
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Immune cells in cancer
- Coronary Artery Anomalies
- CAR-T cell therapy research
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
AbbVie (United States)
2021-2025
Jiangsu Province Hospital
2011-2025
Nanjing Medical University
2011-2025
Zhejiang University
2025
Nanjing Drum Tower Hospital
2013-2024
Soochow University
2016-2024
Wuhan University
2022-2024
Renmin Hospital of Wuhan University
2022-2024
Nanjing University of Chinese Medicine
2024
Anhui University
2024
Abstract Background The extracellular matrix (ECM) is essential for malignant tumour progression, as it a physical barrier to various kinds of anticancer therapies. Matrix metalloproteinase (MMPs) can degrade almost all ECM components, and macrophages are an important source MMPs. Studies using treat tumours have shown that enter tissue play regulatory role. Methods We modified with designed chimeric antigen receptor (CAR), which could be activated after recognition the HER2 trigger internal...
To evaluate the incidence and risk factors of postoperative pneumonia (POP) in geriatric patients with a hip fracture after surgery, to design predictive nomogram, validate accuracy nomogram.Retrospective study.A tertiary hospital affiliated medical university.We retrospectively studied 1285 surgical-treated from April 2010 2018.Surgical treatment was performed on this study. The procedure methods were classified as: total arthroplasty, hemiarthroplasty, percutaneous fixation, intramedullary...
Ischemia-reperfusion injury (IRI) is a significant contributor to acute kidney (AKI) and associated with substantial morbidity mortality rates. In this study, we aimed investigate the role of NAT10 its ac4C RNA modification in IRI-induced renal injury. Our findings revealed that both expression level kidneys were elevated IRI group compared sham group. Functionally, observed inhibition activity Remodelin or specific knockout led attenuation Furthermore, vitro experiments demonstrated...
4-1BB agonists for cancer immunotherapy have shown good preliminary efficacy in clinical trials, but several of the first-generation agonistic antibodies entering clinic failed due to safety issues. Selenium nanoparticles (SeNPs) exhibit anti-inflammatory, anti-tumor, antioxidant, and immune-modulating properties. In addition, they been detoxifying effects prevent oxidative liver damage. this study, we used an anti-4-1BB antibody combination with SeNPs evaluate anti-lung vitro vivo...
Background High expression levels of programmed death receptor 1 (PD-1) and its ligand (PD-L1) have been observed in thymic epithelial tumors (TET), suggesting their potential as prognostic indicators for disease progression the effectiveness immunotherapy TET. The conventional method obtaining PD-L1 was challenging due to invasive sampling tumor heterogeneity Methods A total 124 patients with pathologically confirmed TET (57 positive, 67 negative) were retrospectively enrolled allocated...
We aimed to evaluate the efficacy and safety of oxaliplatin, 5-fluorouracil (5-FU), leucovorin (LV) (FOLFOX-4) as second-line treatment in patients with advanced biliary tract cancer (BTC) failing gemcitabine/cisplatin first-line chemotherapy.Thirty-seven BTC refractory chemotherapy were included study. FOLFOX-4 regimen consisted oxaliplatin (85 mg/m(2)) a 2-hour infusion on day 1 LV (200 mg/m(2)/day) followed by 5-FU bolus (400 22-hour (600 for two consecutive days every 2 weeks. The...
The expression of programmed cell death ligand 1(PD-L1) is related to the efficacy immune checkpoint inhibitors on patients with non-small lung cancer (NSCLC), but tumor tissue (TT) samples are difficult obtain, and initial TT reflect spatial-temporal heterogeneity. Therefore, we explored feasibility separating circulating cells (CTCs) detecting PD-L1 CTCs.Peripheral blood specimens were sampled from 66 NSCLC patients, CTCs separated by membrane filtration based size. For 59 paired...
Background: Because of the different genetic backgrounds, living environments and economic conditions, epidemiologic, clinical characteristics risk factors for coronary artery abnormalities (CAAs) in Chinese population may differ among parts China.
Background: Non-muscle invasive bladder cancer (NMIBC) is one of the most common malignant tumors urinary system. There an urgent need for further studies to elucidate underlying mechanisms (BC) progression. It has been observed that C-C chemokine ligand 5 (CCL5) and its receptor type (CCR5) are expressed abnormally activated in solid hematological malignancies, which gaining increasing attention. However, mechanism CCL5 BC remains unclear. Methods: The expression levels were analyzed by...
Abstract Objective Personalized chemotherapy based on molecular biomarkers can maximize anticancer efficiency. We aim to investigate predictive capable of predicting response irinotecan-based treatment in gastric cancer. Methods examined gene expression APTX, BRCA1, ERCC1, ISG15, Topo1 and methylation SULF2 formalin-fixed paraffin-embedded cancer tissues from 175 patients evaluated the association between levels or status vitro sensitivity irinotecan. used multiple linear regression analysis...
Epstein-Barr virus (EBV) infection is associated with a better response to anti-PD1 immunotherapy. We hypothesised that genetic alterations induced by EBV are responsible for the activation of key immune responses and hence predictive efficacy.With transcriptome data gastric cancer (GC), we explored differentially expressed genes (DEGs) specific performed coexpression network analysis using DEGs identify consistent (CCGs) between EBV-positive EBV-negative GC tissues. selected tag CCGs...
Predictive biomarkers based individualized chemotherapy can improve efficacy.However, for those advanced patients, it may be impossible to obtain the tissues from operation.Tissues biopsy not always enough gene detection.Thus, biomarker blood could a non-invasive and useful tool provide real-time information in procedure of treatment.To further understand role plasma mRNA chemo-efficiency prediction, several expression levels were assessed paired tumor 133 locally gastric cancer patients...
To explore patients' knowledge, attitude, and practice (KAP) toward varicocele in China the relationship between treatment selection KAP.
To build a prognostic and immunotherapeutic response prediction model for liver cancer based on marker genes of tumor-associated endothelial cell (TEC).Single sequencing data from Gene Expression Omnibus (GEO) patients were utilized to identify TEC subpopulations. Models built transcriptomic clinical TCGA patients. The GSE76427 ICGC databases used as independent validation sets. Time-dependent receiver operating characteristic (ROC) curves Kaplan-Meier verify the ability predict survival....