A5072636288- Polyamine Metabolism and Applications
- Plant tissue culture and regeneration
- Transgenic Plants and Applications
- Trace Elements in Health
- Iron Metabolism and Disorders
- Peptidase Inhibition and Analysis
- Folate and B Vitamins Research
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Helicobacter pylori-related gastroenterology studies
- PI3K/AKT/mTOR signaling in cancer
- Cell Adhesion Molecules Research
- Patient Dignity and Privacy
- Ferroptosis and cancer prognosis
- Grief, Bereavement, and Mental Health
- Cancer-related gene regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- FOXO transcription factor regulation
- Atherosclerosis and Cardiovascular Diseases
- Adenosine and Purinergic Signaling
- Cancer Cells and Metastasis
- Hemoglobinopathies and Related Disorders
- Estrogen and related hormone effects
- Cancer Mechanisms and Therapy
Nanjing Drum Tower Hospital
2019-2024
Nanjing University
2018-2021
Second Affiliated Hospital of Guangzhou Medical University
2021
Guangzhou Medical University
2021
Nanjing Medical University
2018-2021
Peritoneal metastasis (PM) occurs frequently in patients with gastric cancer (GC) and confers poor survival. Lipid metabolism acts as a non-negligible regulator epithelial-mesenchymal transition (EMT), which is crucial for the of GC. As apolipoprotein C2 (APOC2) key activator lipoprotein lipase triglyceride metabolism, exact mechanism APOC2 remains largely unknown
Abstract Background In many countries, nurses are ill-prepared to provide care patients with terminal illnesses. Limited education and training affect their ability deliver proper palliative care. Only a few studies have explored appropriate effective methods of in China. Therefore, we aimed evidence for system by appraising the effects mixed-method intervention on participants’ knowledge attitudes towards dying death. Methods An e-learning approach was adopted 97 from oncology departments...
Abstract Anoikis is a type of programmed cell death induced by detachment from the extracellular matrix. In cancer cells, anoikis resistance essential for survival in blood circulation and distant metastasis. However, mechanisms behind gastric remain largely unknown. Herein, we demonstrate that NADPH oxidase 4 (NOX4) expression reactive oxygen species (ROS) generation are upregulated suspension cultures compared with adherent cultures. Silencing NOX4 decreases ROS downregulates EGFR,...
The accumulation of adenosine in the tumor microenvironment is associated with progression many cancers. However, whether involved gastric cancer (GC) metastasis and progression, underlying molecular mechanism, largely unclear. In this study, we find that GC tissues cell lines had higher A2aR levels than nontumor lines. expression correlated positively TNMstage, poor outcomes. Adenosine enhanced stemness epithelial-mesenchymal transition-associated genes by binding to A2aR. on cells promoted...
Abstract Gastric cancer is one of the most common malignancies worldwide and vasculogenic mimicry (VM) considered to be leading cause for failure anti-angiogenesis therapy in advanced gastric patients. In present study, we investigate role tenascin-c (TNC) formation VM found that TNC was upregulated tissue than corresponding adjacent tissues correlated with poor prognosis cancer. Furthermore, knockdown significantly inhibited proliferation cells vitro vivo, a reduction cell migration...
G protein coupled estrogen receptor (GPER1) is a membrane receptor, belonging to the seven-transmembrane protein-coupled receptors family, and has important biological functions in cancer. However, functional role of GPER1 gastric cancer (GC) remain incompletely understood. In present study, we employed gene set enrichment analysis discovered that expression was concomitant with EMT process positively correlated activation PI3K/AKT pathway GC. Knockdown siRNA suppressed proliferation,...
The extracellular matrix (ECM) plays a central role in the formation of tumor microenvironment. deposition ECM is associated with poor prognosis variety tumors. Aberrant could undermine effect chemotherapy and immunotherapy. However, there no systematic analysis on relationship between or effect. In present study, we applied gene set variation (GSVA) algorithm to score 2199 canonical pathways 2125 cases probe sequencing data identified core matrisome as driving factor gastric cancer...
Abstract In gastric cancer (GC), the liver is a common organ for distant metastasis, and patients with metastasis (GCLM) generally have poor prognosis. The mechanism of GCLM unclear. Invadopodia are special membrane protrusions formed by tumor cells that can degrade basement ECM. Herein, we investigated role invadopodia in GCLM. We found levels invadopodia‐associated proteins were significantly higher than primary tumors Furthermore, GC could activate hepatic stellate (HSCs) within...
Little is known about the iron efflux from pancreas, but it likely that multicopper ferroxidases (MCFs) are involved in this process. We thus used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout mice Heph/Cp double-knockout to investigate roles of MCFs pancreatic homeostasis. found both HEPH CP were expressed mouse ablation either MCF had limited effect on levels. However, together led extensive deposition severe oxidative damage. Perls’ Prussian blue staining revealed was...
Abstract Photothermal therapy (PTT) is an emerging noninvasive and precise localized therapeutic modality; however, it deeply limited by its poor tumor accumulation, inadequate photothermal conversion efficiency, the thermoresistance of cancer cells. Aimed at these shortcomings, tumor‐targeting nanoparticles (iRGD‐W 18 O 49 ‐17AAG) comprising carboxyl‐group‐functionalized W nanoparticles, integrin‐targeting peptide iRGD, HSP90‐inhibitor 17AAG are developed. The act as excellent PTT carriers...
Brain iron deposition is a feature of Alzheimer disease and may contribute to its development. However, the relative contribution dietary remains unclear. We investigated impact high on brain pathological changes cognitive function in adult wild-type (WT) mice amyloid precursor protein/presenilin 1 (APP/PS1) double transgenic mice. Male WT APP/PS1 aged 10 wk were fed either control diet (66 mg Fe/kg) (WT-Ctrl APP/PS1-Ctrl) or (14 g (WT-High Fe APP/PS1-High Fe) for 20 wk. Iron concentrations...
Signet ring cell gastric carcinoma (SRCGC) is a poorly differentiated malignancy, and can be highly dangerous in the progression stage. There higher male to female ratio among patients with signet as compared non-SRCGC. ERβ has been found express stomach adenocarcinoma, but how it affects tumor remains unclear. Here, we studied estrogen receptor beta (ERβ) explore role of sex-associated factors SRCGC. We analyzed clinicopathological statistics SRCGC, conducted series vitro experiments....
Abstract Background WD40 repeat (WDR)43 is an RNA-binding protein that belongs to the WDR domain family. Its biological function largely unclear, particularly in colorectal cancer (CRC). Methods In present study, we searched TCGA database and found correlation between WDR43 CRC. Subsequently, high expression of human clinical samples CRC was validated further examined functions it cells. Finally, explored potential downstream proteins or pathways established subcutaneous xenograft model...
Gastric cancer is one of the most common malignancies worldwide and third leading cause cancer-related death. In present study, we investigated potential activity OSI-027, a potent selective mammalian target rapamycin complex 1/2 (mTOR1/2) dual inhibitor, alone or in combination with oxaliplatin against gastric cells vitro. Cell counting kit-8 assays EdU staining were performed to examine proliferation cells. cycle apoptosis detected by flow cytometry. Western blot was used detect elements...
Abstract Background: Peritoneal metastasis (PM) occurs frequently in patients with gastric cancer (GC) and confers poor survival. Lipid metabolism epithelial-mesenchymal transition (EMT) play an important role GC metastasis. As Apolipoprotein C-II (APOC2) is a key protein lipid metabolism, few studies have investigated the of APOC2 PM. This study aims to elucidate potential molecular mechanism PM GC. Methods: The Tandem Mass Tagging (TMT) method followed by liquid chromatography-tandem mass...
Histidine-rich calcium binding protein (HRC) is a new type of Ca 2+ homeostasis regulator, which acts as nonnegligible role in regulating intracellular homeostasis.Here, we demonstrated that HRC expression was upregulated human gastric cancer (GC) samples, and its level closely correlated with the overall survival (OS) rate GC patients malignant potential cell lines.Knockdown inhibited migration, invasion, proliferation lines vitro, while overexpression promoted well growth subcutaneous...
Abstract Background In many countries, nurses are ill-prepared to provide care patients with terminal illnesses. Limited education and training affect their ability deliver proper palliative care. Only a few studies have explored appropriate effective methods of in China. Therefore, we aimed evidence for system by appraising the effects mixed-method intervention on participants’ knowledge attitudes towards dying death.Methods An e-learning approach was adopted 97 from oncology departments...