A5054346345- Immune cells in cancer
- Selenium in Biological Systems
- Glioma Diagnosis and Treatment
- Iron Metabolism and Disorders
- Trace Elements in Health
- Environmental Toxicology and Ecotoxicology
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Functional Brain Connectivity Studies
- Cancer Immunotherapy and Biomarkers
- Membrane Separation Technologies
- Advanced Neuroimaging Techniques and Applications
- Mercury impact and mitigation studies
- Aquaculture Nutrition and Growth
- Cancer Cells and Metastasis
- Anaerobic Digestion and Biogas Production
- MicroRNA in disease regulation
- Microbial Fuel Cells and Bioremediation
- Additive Manufacturing Materials and Processes
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Injection Molding Process and Properties
- High Entropy Alloys Studies
- Biomarkers in Disease Mechanisms
Shandong University
2024-2025
Hunan University of Science and Technology
2025
Northwest A&F University
2019-2025
Qilu Hospital of Shandong University
2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Huazhong University of Science and Technology
2022-2024
Tongji Hospital
2022-2024
Aero Engine Corporation of China (China)
2024
Binzhou University
2024
In recent years, high-fat diet (HFD) has been widely applied in aquaculture, which reduces the intestinal health of cultured fish. The current study evaluated protective effects nano-selenium (nano-Se) on juvenile grass carp (Ctenopharyngodon idella) fed with HFD. A total 135 experimental fish were a regular (Con), HFD and containing nano-Se at 0.6 mg/kg (HSe) for 10 weeks. results showed that dietary significantly improved survival rate feed efficiency reduced by (P < 0.05). Also, (0.6...
Rationale: In the glioblastoma (GBM) microenvironment, tumor-associated macrophages (TAMs) are prominent components and facilitate tumor growth. The exact molecular mechanisms underlying TAMs' function in promoting glioma stem cells (GSCs) maintenance growth remain largely unknown. We found a candidate molecule, transforming factor beta-induced (TGFBI), that was specifically expressed by TAMs extremely low GBM GSC cells, meanwhile closely related to WHO grades patient prognosis. mechanism of...
Abstract Multicopper ferroxidases (MCFs) play an important role in cellular iron homeostasis. However, the of MCFs renal metabolism remains unclear. We used Hephaestin ( Heph ) and Ceruloplasmin Cp single or double / knockout (KO) mice to study roles kidney. Renal levels expression genes were examined. The non-heme content both cortex medulla KO was significantly increased. Perls’ Prussian blue staining showed accumulation on apical side tubular cells mice. A significant increase ferritin...
To evaluate the effects of dietary nano-selenium (Nano-Se) on antioxidant capacity and hypoxia tolerance grass carp fed with high-fat diet, experimental fishes were Nano-Se supplemented diets at doses 0 (Control), 0.3, 0.6, 0.9 1.2 mg/kg for 10 weeks. After feeding trial, a part exposed to stress. Results showed that survival ratio significantly increased in 0.6 group, content serum alanine aminotransferase (ALT) aspartate (AST) decreased 0.6–1.2 groups compared control group. In addition,...
Curcumin (CCM) has many potential uses in anticancer chemotherapy, but its low water solubility poses a major problem, preventing translation into clinical use. TPGS is water-soluble derivative of vitamin E that acts as surfactant with the ability to form micellar nanoparticles water. More importantly, potent antioxidant can neutralize intracellular reactive oxygen species (ROS). In this study, we solubilized CCM using thin-film rehydration prepare aqueous formulations containing at...
Glioma stem cells (GSCs) in the hypoxic niches contribute to tumor initiation, progression, and recurrence glioblastoma (GBM). Hypoxia induces release of high-mobility group box 1 (HMGB1) from cells, promoting development tumor. Here, we report that HMGB1 is overexpressed human GBM specimens. promotes expression secretion GSCs. Furthermore, silencing results loss cell markers a reduction self-renewal ability Additionally, knockdown inhibits activation RAGE-dependent ERK1/2 signaling pathway...
ASICs (acid-sensing ion channels) are proton-evoked sodium channels, highly distributed in the peripheral and central nervous system. involved pain perception ASIC3 channel is presumed as target of promising analgesics. Peptide drugs have attracted attention pharmaceutical developers due to their advantages such low toxic side effects targeted specificity. Although numbers chemicals acting on emerging, there limited reports peptide inhibitor channel. Here, we found that spider-derived...
Abstract Accumulation of iron has been associated with the pathobiology various disorders central nervous system. Our previous work shown that hephaestin ( Heph ) and ceruloplasmin Cp double knockout (KO) mice induced accumulation in multiple brain regions this was paralleled by increased oxidative damage deficits cognition memory. In study, we enriched astrocytes oligodendrocytes from cerebral cortex neonatal wild-type (WT), KO mice. We demonstrated is highly expressed oligodendrocytes,...
Abstract Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because their short circulation lives, lack specific targeting the hemorrhagic site, poor control drug release. To exploit fact that metal ions such as Fe 2+ more abundant in peri-hematomal tissue healthy red blood cell lysis, we developed ion-responsive nanocarrier based on phosphonated calix[4]arene derivative order...
Little is known about the iron efflux from pancreas, but it likely that multicopper ferroxidases (MCFs) are involved in this process. We thus used hephaestin (Heph) and ceruloplasmin (Cp) single-knockout mice Heph/Cp double-knockout to investigate roles of MCFs pancreatic homeostasis. found both HEPH CP were expressed mouse ablation either MCF had limited effect on levels. However, together led extensive deposition severe oxidative damage. Perls’ Prussian blue staining revealed was...
Brain iron deposition is a feature of Alzheimer disease and may contribute to its development. However, the relative contribution dietary remains unclear. We investigated impact high on brain pathological changes cognitive function in adult wild-type (WT) mice amyloid precursor protein/presenilin 1 (APP/PS1) double transgenic mice. Male WT APP/PS1 aged 10 wk were fed either control diet (66 mg Fe/kg) (WT-Ctrl APP/PS1-Ctrl) or (14 g (WT-High Fe APP/PS1-High Fe) for 20 wk. Iron concentrations...
The development and progression of glioma are associated with the tumor immune microenvironment. Diffuse low-grade gliomas (LGGs) higher immunosuppressive microenvironment tend to have a poorer prognosis. study aimed find biological marker that can reflect status predict prognosis LGGs. target gene tenascin-C (TNC) was obtained by screening Chinese Glioma Genome Atlas (CGGA) Cancer (TCGA) databases. Then samples LGGs were collected for experimental verification immunohistochemistry,...