A5101456087- Cancer Research and Treatments
- Pharmacological Effects of Natural Compounds
- Probiotics and Fermented Foods
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Traditional Chinese Medicine Analysis
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Ferroptosis and cancer prognosis
- Neuropeptides and Animal Physiology
- Prostate Cancer Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Phytochemicals and Antioxidant Activities
- Ion channel regulation and function
- Healthcare and Venom Research
- Helicobacter pylori-related gastroenterology studies
- Skin and Cellular Biology Research
- Acute Kidney Injury Research
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Osteoarthritis Treatment and Mechanisms
China Pharmaceutical University
2014-2024
Jinan Central Hospital
2014-2024
Shandong First Medical University
2024
China Medical University
1997-2023
First Hospital of China Medical University
2017-2023
National Health and Family Planning Commission
2023
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2021
Qilu Hospital of Shandong University
2021
State Key Laboratory of Natural Medicine
2018-2020
Drexel University
2013-2016
Ferroptosis is an iron-dependent regulated necrosis and has been proven to contribute the progress of acute kidney injury (AKI). Quercetin (QCT), a natural flavonoid which commonly found in numerous fruits vegetables, extensive pharmacological effects, such as anti-oxidant, anti-inflammatory anti-senescence effects. This study aims explain whether ferroptosis therapeutic strategy AKI, explore effect QCT on AKI ferroptosis. NRK-52E cells HK-2 were used for vitro studies. Morphology was...
Significance Stress cannot be avoided in the present competitive world, and chronic stress is associated with detrimental effects on physical health, including progression of inflammatory bowel disease (IBD). However, mechanisms behind it are less clearly understood. This study showed that disturbed gut microbiota, thereby triggering immune system response facilitating dextran sulfate sodium-induced colitis. Results also stress-deficient expression mucin-2 lysozyme, which may contribute to...
The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway mechanism AKI is poorly understood. In this study, we conducted an RNA-sequence analysis of kidneys and normal mice to explore the ferroptosis. Consequently, differentially expressed genes highlighted Acyl-CoA synthetase long-chain family (ACSL4), a known promotor for Besides, RT-PCR, Western blot, immunohistochemical analyses confirmed upregulation. HIF-1α was downregulated I/R-AKI mice, vitro studies...
Abstract Colorectal cancer development and outcome are impacted by modifiable risk factors, including psychologic stress. The gut microbiota has also been shown to be linked factors. Here, we found a marked deteriorative effect of chronic stress in multiple colorectal models, chemically induced (AOM/DSS), genetically engineered (APCmin/+), xenograft tumor mouse models. RNA sequencing data from colon tissues revealed that expression stemness-related genes was upregulated the stressed group...
Background Atopic dermatitis (AD) is the most prevalent chronic inflammatory skin disease in children characterized by and pruritus. MicroRNAs (miRNAs) have been shown as great potential biomarkers for fingerprints to predict prognostics. We aimed identify miRNA signature from serum urine prognosis of AD patient genome-wide profiling analysis. Methods Serum 30 with 28 healthy were collected their expression profiles measured TaqMan-based array confirmed quantitative real-time PCR....
The objective of this study was to evaluate the topical effects sea buckthorn (SBT) oil on atopic dermatitis (AD)-like lesions in a mouse model generated by repeated administration DNCB BALB/c mice.DNCB applied repeatedly dorsal skin mice induce AD-like lesions. Following AD induction, SBT daily for 4 weeks. severity examined macroscopically and histologically. We further measured production MDC/CCL22 TARC/CCL17 IFN-γ/TNF-α activated HaCaT cells.Topically DNCB-treated ameliorated score...
Abstract Background Defect in the SPINK5 gene is known to be implicated Netherton syndrome (NS), and has been suggested a locus predisposing atopy general. Coding polymorphisms exons 13, 14 26 have reported associated with atopic dermatitis (AD), asthma high level of IgE. Objectives To examine whether are AD Northeast China, assess how variants influence selected phenotypic traits. Methods A case–control study was conducted on four non‐synonymous coding region controls. The were analyzed...
Our previous study demonstrated that a store-operated calcium channel (SOCC) inhibitor (YM-58483) has central analgesic effects. However, the cellular and molecular mechanisms of such effects remain to be determined. It is well-known glial cells play important roles in sensitization. SOC entry (SOCE) been implicated many cell types including cortical astrocytes. role SOCC family function astrocytes not Here, we thoroughly investigated expression functional significance SOCCs spinal Primary...
Background: Ulcerative colitis (UC) is a chronic inflammatory gastrointestinal disease, notoriously challenging to treat.Previous studies have found positive correlation between thymic atrophy and severity.It was, therefore, worthwhile investigate the effect of thymopentin (TP5), synthetic pentapeptide corresponding active domain thymopoietin, on colitis.Methods: Dextran sulfate sodium (DSS)-induced mice were treated with TP5 by subcutaneous injection.Body weight, colon length, immune organ...
Radix Pseudostellariae is used as a tonic drug in traditional Chinese medicine with immunomodulating and anti-fatigue activities, the polysaccharide considered main active component. The purpose of this study to examine effect isolated from (PRP) on mouse chronic fatigue syndrome (CFS) induced by intraperitoneal injection polyriboinosinic:polyribocytidylic acid (poly I:C), double-stranded synthetic RNA. It has shown that symptom mice lasted at least 1 week evaluated forced swimming time. PRP...
Chronic pain often accompanies immune responses and cells are known to be involved in chronic pain. Store-operated calcium (SOC) channels calcium-selective cation play an important role the system. YM-58483, a potent SOC channel inhibitor, has been shown inhibit cytokine production from attenuate antigen-induced hypersensitivity reactions. Here, we report that YM-58483 analgesic actions produces antinociceptive effects acute prevents development of mice. Oral administration 10mg/kg or 30...
Store-operated calcium channels (SOCs) are calcium-selective cation that mediate entry in many different cell types. (SOCE) is involved various cellular functions. Increasing evidence suggests impairment of SOCE responsible for numerous disorders. A previous study demonstrated YM-58483, a potent SOC inhibitor, strongly attenuates chronic pain by systemic or intrathecal injection and completely blocks the second phase formalin-induced spontaneous nocifensive behaviour, suggesting potential...
Pathological pain is a common and debilitating condition that often poorly managed. Central sensitization an important mechanism underlying pathological pain. However, candidate molecules involved in central remain unclear. Store-operated calcium channels (SOCs) mediate signals nonexcitable excitable cells. SOCs have been implicated wide variety of human pathophysiological conditions, including immunodeficiency, occlusive vascular diseases, cancer. the role CNS disorders has relatively...
Store-operated calcium (SOC) channels are thought to play a critical role in immune responses, inflammatory diseases and chronic pain. The aim of this study was explore the potential mechanisms SOC collagen-induced arthritis (CIA).The CIA mouse model used examine effects channel inhibitor YM-58483 on arthritic Hargreaves' von Frey hair tests were conducted measure thermal mechanical sensitivities hind paws. elisa performed cytokine production, haematoxylin eosin staining assess knee...
Bullous pemphigoid (BP) has been reported to be associated with significant morbidities and a considerable mortality rate. We retrospectively studied 94 patients BP in Chinese tertiary medical center between 2005 2010 evaluate the treatment of prognostic factors for BP. Cerebrovascular diseases (42.55%) hypertension (39.36%) were most common pre-existing conditions. Cardiopathy, diabetes psoriasis pre-existed 24.47%, 22.34% 5.32%, respectively. Eighty all treated by systemic corticosteroid...