A5014415003- Pharmacological Effects of Natural Compounds
- Cancer Research and Treatments
- Probiotics and Fermented Foods
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Food Allergy and Anaphylaxis Research
- Hepatitis B Virus Studies
- Microbial Metabolism and Applications
- Epigenetics and DNA Methylation
- Blood Pressure and Hypertension Studies
- Immune cells in cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Ureteral procedures and complications
- Adipokines, Inflammation, and Metabolic Diseases
- Ion Channels and Receptors
- Helicobacter pylori-related gastroenterology studies
- Immune Cell Function and Interaction
- Cardiac Health and Mental Health
- interferon and immune responses
- Minimally Invasive Surgical Techniques
- Phagocytosis and Immune Regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiovascular Syncope and Autonomic Disorders
- Peripheral Artery Disease Management
China Pharmaceutical University
2020-2025
Xuzhou Medical College
2024-2025
Affiliated Hospital of Jining Medical University
2021-2023
Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function IRG1/ITA has been established in multiple pathogen models, but very little is known cancer. Here, we show IRG1 expressed tumor-associated macrophages (TAMs) both human and mouse tumors. Mechanistically, tumor cells induce Irg1 expression by activating NF-κB pathway, ITA produced ACOD1 inhibits TET DNA dioxygenases to dampen...
Abstract Here we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. In two different HBV carrier mouse models generated by viral vector-mediated transfection (pAAV-HBV1.2 rAAV8-HBV1.3), this demonstrates sufficient persistent virological suppression, robust immunogenicity in terms induction strong innate immune activation, high-level virus-specific antibodies, memory cells T cells. platform therefore holds prospects therapeutic...
Abstract Colorectal cancer development and outcome are impacted by modifiable risk factors, including psychologic stress. The gut microbiota has also been shown to be linked factors. Here, we found a marked deteriorative effect of chronic stress in multiple colorectal models, chemically induced (AOM/DSS), genetically engineered (APCmin/+), xenograft tumor mouse models. RNA sequencing data from colon tissues revealed that expression stemness-related genes was upregulated the stressed group...
Food allergy has posed a major global health burden due to the rising prevalence and lack of effective prophylactic strategies. During past decades, allergen-specific immunotherapy (AIT) been used as disease-modifying therapy for food allergic conditions, but long-term treatment duration, poor patient compliance unexpected adverse reactions, only minority patients benefit from AIT therapy. In this proof-of-concept study, using well-established mRNA platform, we developed vaccine candidates...
Background and Purpose Inflammatory bowel diseases (IBDs) constitute chronic inflammatory disease of the gastrointestinal tract, with escalating global prevalence. There is a pressing demand for safe effective treatments IBDs. Fibroblast growth factor 1 (FGF1) variant FGF1 ΔHBS , characterised by reduced mitogenic capacity, has shown promising therapeutic potential in various conditions, including obesity diabetic nephropathy. Hence, exploring impact on colitis warranted. Experimental...
Highlights•Macrophage L2HGDH deficiency restricts tumor progression•S-2HG accumulation caused by blockage guides macrophage antitumoral polarization•S-2HG promotes polarization dependent on α-KG inhibition•S-2HG increases antigen presentation and enhances antitumor T cell immunitySummaryThe high infiltration of tumor-associated macrophages (TAMs) in the immunosuppressive microenvironment prominently attenuates efficacy immune checkpoint blockade (ICB) therapies, yet underlying mechanisms are...
BRIEF ABSTRACT Here we report on the development and comprehensive evaluations of an mRNA vaccine for chronic hepatitis B (CHB) treatment. In two different HBV carrier mouse models generated by viral vector-mediated transfection (pAAV-HBV1.2 rAAV8-HBV1.3), this demonstrates sufficient persistent virological suppression, robust immunogenicity in terms induction strong innate immune activation, high-level virus-specific antibodies, memory cells T cells. platform therefore holds prospects...
There is no clear evidence for the target value of blood pressure control after Percutaneous coronary intervention (PCI). Therefore, our study was designed to explore relationship between PCI and major adverse cardiac events (MACE) during 3-year follow-up.This a prospective study. We included patients who were diagnosed with acute syndrome underwent stent implantation operation. The initially collected information 552 patients. start end times are from January 1, 2017 December 31, 2020....
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<p>Supplementary Materials and Methods.</p>
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<div>Abstract<p>Colorectal cancer development and outcome are impacted by modifiable risk factors, including psychologic stress. The gut microbiota has also been shown to be linked factors. Here, we found a marked deteriorative effect of chronic stress in multiple colorectal models, chemically induced (AOM/DSS), genetically engineered (APC<sup>min/+</sup>), xenograft tumor mouse models. RNA sequencing data from colon tissues revealed that expression stemness-related...
<p>Supplementary Table.</p>
<p>Figure S7</p>
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