A5102935465- Spine and Intervertebral Disc Pathology
- PI3K/AKT/mTOR signaling in cancer
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
- Cervical and Thoracic Myelopathy
- Genetics and Neurodevelopmental Disorders
- Monoclonal and Polyclonal Antibodies Research
- Receptor Mechanisms and Signaling
- Ocular Surface and Contact Lens
- Retinal and Macular Surgery
- Endometriosis Research and Treatment
- Toxin Mechanisms and Immunotoxins
- Glaucoma and retinal disorders
- Nuclear Receptors and Signaling
- Cancer and Skin Lesions
- Ginseng Biological Effects and Applications
- Medicinal Plants and Bioactive Compounds
- MRI in cancer diagnosis
- Appendicitis Diagnosis and Management
- Bone Tumor Diagnosis and Treatments
- Ophthalmology and Visual Impairment Studies
- Synthesis and biological activity
- Medical Research and Treatments
Ningbo University
2024
First Affiliated Hospital of Xiamen University
2022
Xiamen University
2017-2022
China Pharmaceutical University
1993-2021
Brown University
2018-2021
Rhode Island Hospital
2018-2021
University of Massachusetts Chan Medical School
2021
Cleveland Clinic
2010-2020
Xi'an Jiaotong University
2016-2020
Xi'an Honghui Hospital
2016-2020
An efficient and facile process was developed for the remote C-H bond amidation of 8-aminoquinoline scaffolds on C5 position which is geometric. The method only made use PhI(OAc)2 as a mediator showed good tolerance toward numerous dibenzenesulfonimides amides, giving corresponding products in moderate to excellent yield.
Indoleamine 2,3-dioxygenase-1 (IDO1) plays an important role in tumor immune escape. However, unsatisfactory clinical efficacies of selective IDO1 inhibitors have impeded their further development, suggesting that they do not exert sufficient antitumor effects by selectively inhibiting IDO1. IDO2, isoenzyme IDO1, is overexpressed some human tumors, and emerging evidence suggests concomitant inhibition IDO1/2 may synergistic cancer treatment, revealing a promising immunotherapeutic strategy....
Radix Pseudostellariae is used as a tonic drug in traditional Chinese medicine with immunomodulating and anti-fatigue activities, the polysaccharide considered main active component. The purpose of this study to examine effect isolated from (PRP) on mouse chronic fatigue syndrome (CFS) induced by intraperitoneal injection polyriboinosinic:polyribocytidylic acid (poly I:C), double-stranded synthetic RNA. It has shown that symptom mice lasted at least 1 week evaluated forced swimming time. PRP...
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by impairment in social communication/interaction and inflexible/repetitive behavior. Several lines evidence support genetic factors as predominant cause ASD. Among those autism susceptibility genes that have been identified, the PTEN tumor suppressor gene, initially identified predisposing to Cowden heritable cancer syndrome, was found be mutated subset ASD patients with extreme macrocephaly. However,...
NVP-BEZ235 is a newly developed dual PI3K/mTOR inhibitor, being tested in multiple clinical trials, including breast cancer. selectively induces cell growth inhibition subset, but not all, cancer lines. However, it remains challenge to distinguish between sensitive and resistant tumors, particularly the pretreatment setting. Here, we used ten lines compare sensitivity context of androgen receptor (AR) activation during treatment. We also female SCID mice bearing tumor xenografts investigate...
Germline mutations in PTEN have been described a spectrum of syndromes that are collectively known as hamartoma tumor syndrome (PHTS). In addition to being mutated the germline PHTS, somatic loss-of-function seen wide range sporadic human tumors. Here, we show evidence upregulated proteasome activity PHTS-derived lymphoblasts, Pten knock-in mice and cell lines expressing missense nonsense mutations. Notably, elevated nuclear occurred cells mislocalized PTEN-K62R mutant, whereas cytosolic was...
Background Pulmonary tumor embolism (PTE) is difficult to detect before death, and it unclear whether the discrepancy between antemortem clinical postmortem diagnosis improves with advance of diagnostic technologies. In this study we determined incidence PTE analyzed diagnosis. Methods We performed a retrospective autopsy on patients history malignant solid tumors from 1990 2020 reviewed all slides PTE. also discrepancies in 1999, 2009 2019 by using Goldman criteria. category major 1 refers...
Objective To investigate the surgery outcomes between patients with different recovery states measured by visual analog scores (VAS), explore relationships among outcomes, bone cement, and degrees of pain relief, to find out best combination cement volume distribution for Percutaneous kyphoplasty (PKP). Methods There were 220 vertebra, from January 2012 2014, who received PKP in our hospital. Patients divided into two groups, on basis VAS. The epidemiological data, operative effect,...
Thyroid cancer is a major component of Cowden syndrome (CS). CS patients with an underlying PTEN mutation (PTEN(mut+)) have 70-fold increased risk developing epithelial thyroid cancer. In contrast, less than 1% sporadic carry germline mutation. Cost-efficient markers capable shortlisting cancers for genetic testing would be clinically useful.Our objective was to analyze the utility patient blood phosphate and tensin homolog deleted on chromosome 10 (PTEN) protein levels in predicting...
Germline mutations in PTEN are associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) hamartoma tumor syndrome including Cowden (CS) Cowden-like (CSL) that predisposes to high risks of benign malignant tumors thyroid breast.The objective the study was analyze subcellular pattern phosphorylated (P)-AKT expression nonmedullary cancers from patients investigate whether lack nucleus and/or proper function affect(s) nuclear AKT activity CS patients.In all, 664 CS/CSL were...
Objective To provide useful insights of multidisciplinary surgical treatment for vertebral hemangioma with spinal cord compression. Methods From 2009 to 2014, data on six patients who were diagnosed compression reviewed and analyzed retrospectively. There five women one man a mean age 48.6 years (range, 26‐68 years). All the treated by approach, including use gelfoam, pedicle screw instrumentation, vertebroplasty, decompression laminectomy. Neurological status Frankel grades documented, CT...
Under the effective chemotherapy protocol, physeal distraction could be used as an limb salvage in growing children with lower‐limb malignant metaphyseal bone tumours and actively prevent leg length discrepancy or malalignment that profoundly affects function. In this paper, we report a 7‐year‐old boy right distal tibial osteosarcoma but not yet invaded epiphysis, which underwent surgical treatment after chemotherapy. The procedure included two phases: epiphysiolysis (physeal distraction)...
The aim of the present study was to examine curative effect dynamic fixation Coflex treatment for patients with degenerative lumbar spinal stenosis. In study, 78 stenosis were recruited and divided equally into control observation groups. group treated traditional decompression fusion received system. Surgery hospitalization shorter in than group. Intraoperative blood loss drainage volume after surgery significantly lower compared effective rate higher. Visual analogue scale, Oswestry...
Purpose: To investigate microenvironment changes of the lacrimal gland after obstruction ducts. Methods: The ducts rat exorbital were ligated by sutures for different durations. After that, in some animals released, and they observed 21 days to evaluate recovery gland. Slit lamp tear secretion test was performed ocular surface function. cornea harvested processed hematoxylin eosin staining, oil red O LipidTOX Masson quantitative real time polymerase chain reaction, immunofluorescence...
This study is to assess an innovative technique - a vertebral osteotome (VO) combined with side-opening injection cannula for percutaneous vertebroplasty (PVP).A retrospective by propensity score matching. From January 2016 April 2016, 63 patients who were diagnosed monosegmental osteoporotic compression fracture received the technique. The epidemiologic data, surgical indexes, and recovery outcomes collected in follow-up period. Propensity matching identified pairs form historical controls...
Three new zinc(II) complexes, [ZnCl2L]·CH3OH (1), [ZnClL(NCS)]·2CH3OH·0.5H2O (2), and [ZnL(NCS)2]·CH3OH·H2O (3), where L is the zwitterionic form of 5-bromo-2-(((2-piperazin-1-yl)ethyl)imino)methyl)phenol, NCS thiocyanate anion, were facile prepared by reaction different molar ratio L, zinc chloride ammonium in methanol. The complexes characterized IR UV-Vis spectroscopy. Detailed structures three confirmed single crystal X-ray determination. Zn atoms are tetrahedral coordination. Schiff...
Fine needle aspiration cytology (FNA) is a simple, safe, cost effective, and accurate method for diagnosis of cystic lesions the breast. Our study aims to correlate FNA breast with histologic diagnosis.During period 10 years (2007-2017), 314 cases were retrieved from total 1073 FNAs. Of these, 78 77 patients (mean age = 54.6, female: male 76:1) simultaneous core biopsy (CNB) and/or excision specimen reviewed. The reports correlated histology results CNB (n 72) 20).Overall, 73 (93.6%)...