A5009365745- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Prostate Cancer Treatment and Research
- Molecular Biology Techniques and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Smoking Behavior and Cessation
- Genomic variations and chromosomal abnormalities
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Genetic Associations and Epidemiology
- Infectious Diseases and Mycology
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- Esophageal Cancer Research and Treatment
- Noise Effects and Management
- MicroRNA in disease regulation
- Cancer Treatment and Pharmacology
- Sirtuins and Resveratrol in Medicine
- Polyamine Metabolism and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Lipids, and Metabolism
University of Arkansas for Medical Sciences
2015-2024
Winthrop Rockefeller Foundation
2018-2024
University of Arkansas Medical Center
2024
Cornell University
2024
Cleveland Clinic
2008-2015
Cleveland Clinic Lerner College of Medicine
2009-2015
The Ohio State University
2012
Case Western Reserve University
2005-2012
Eastern Hepatobiliary Surgery Hospital
2011
Second Military Medical University
2011
Abstract Purpose: Age-adjusted cancer incidence and age-related penetrance studies have helped guide risk assessment management. PTEN hamartoma tumor syndrome (PHTS) is a term encompassing subsets of several clinical syndromes with germline mutations in the suppressor gene. We conducted first prospective study to clarify corresponding risks shed biologic insights on human mutations, better inform current surveillance recommendations basis expert opinion. Experimental Design: A series 3,399...
Germline phosphatase and tensin homolog (PTEN) mutations cause Cowden syndrome (CS), associated with breast thyroid cancers. Case reports found 35%-85% of CS patients had gastrointestinal (GI) hamartomas. The association benign malignant GI neoplasias remains debatable. Our goal is to describe the phenotype in a prospective series PTEN mutation carriers.Patients who met relaxed International Consortium criteria (N = 2548) or 5 more polyps, 1 which was hyperplastic hamartomatous 397), were...
Barrett esophagus (BE) occurs in 1% to 10% of the general population and is believed be precursor esophageal adenocarcinoma (EAC). The incidence EAC has increased 350% last 3 decades without clear etiology. Finding predisposition genes may improve premorbid risk assessment, genetic counseling, management. Genome-wide multiplatform approaches lead identification important BE/EAC development.To identify alleles or mutated associated with BE/EAC.Model-free linkage analyses 21...
Non-small cell lung cancer (NSCLC) is the major form of cancer, with adenocarcinoma (LUAD) and squamous carcinoma (LUSC) being its subtypes. Smoking alone cannot completely explain etiology. We hypothesize that altered microbiome chronic inflammatory insults in tissues contribute to carcinogenesis. Here we explore composition LUAD samples, compared LUSC normal samples. Extraction DNA formalin-fixed, paraffin-embedded (FFPE) tumor adjacent was meticulously performed. The 16S rRNA product from...
Cowden syndrome (CS), a Mendelian autosomal-dominant disorder, predisposes to breast, thyroid and other cancers. Germline mutations in phosphatase tensin homolog (PTEN) have been recently reported 23% of large series classic CS. Here, we validated our small (n = 10) pilot study patient that germline variations succinate dehydrogenase genes (SDHx) occur 8% (49/608) PTEN mutation-negative CS CS-like (CSL) individuals (SDHvar+). None these SDHx variants was found 700 population controls (P <...
The tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) the androgen receptor (AR) play important roles in development progression prostate carcinogenesis. Among many functions, negatively regulates cytoplasmic phosphatidylinositol-3-kinase/AKT anti-apoptotic pathway; nuclear affects cell cycle by also regulating MAPK pathway via cyclin D. Decreased expression is correlated with cancer progression. Over-expression of AR upregulation transcriptional activity...
Background: Differentiated thyroid cancer (DTC) is seen in 3%–10% of individuals carrying a germline PTEN mutation. Patients with mutations are at risk for additional neoplasms as their affected offspring. However, the frequency among DTC cases has not been systematically analyzed. The objective this study was to determine an unselected group patients and identify whether clinical features might indicate need referral genetic counseling possible testing. Methods: We collected personal...
It was traditionally believed that the tumor seed lay in passive soil of microenvironment, with latter providing "permissive elements" for to grow and invade. Subsequently, it recognized both neoplasia its microenvironment interacted as equal partners. Recent advances addressing genomic alterations relevant clinical outcome treatment choices, are summarized. These include microenvironmental not only different solid tumors, but also, rather surprisingly, inflammatory bowel disease....
Although smoking is a strong risk factor for lung diseases including asthma, COPD, and asthma-COPD overlap syndrome (ACOS), studies are needed to examine the association between e-cigarettes ACOS. This study evaluated e-cigarette use self-reported diagnosis of ACOS using large nationally representative sample adults aged ≥18 years in United States.Cross-sectional data from Behavioral Risk Factor Surveillance System (BRFSS) 2016 2018 were used information on current use, demographic...
Correction: Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) asthma-COPD overlap syndrome among never smokers
Recent studies suggest that tumor microenvironment (stroma) is important in carcinogenesis and progression. We sought to integrate global genomic structural expressional alterations prostate cancer epithelium stroma their association with clinicopathologic features.We conducted a genome-wide LOH/allelic imbalance (AI) scan of DNA from 116 cancers. LOH/AI hot or cold spots were defined as the markers significantly higher lower frequencies compared average frequency for along same chromosome....
Wilms' tumor gene (WT1) is important for nephrogenesis and gonadal growth. WT1 mutations cause Denys-Drash Frasier syndromes, which are characterized by glomerular scarring. To test whether genetic variations in WIT1 (gene immediately 5' to WT1) associate with focal segmental glomerulosclerosis (FSGS), patients biopsy-proven idiopathic HIV-1-associated FSGS were enrolled a multicenter study. We genotyped SNP rs6508 located exon 1, three SNPs (rs2301250, rs2301252, rs2301254) the promoter...
Gastric cancer is the third leading cause of mortality worldwide. Studies investigating effect salt on gastric have mainly used self-reported measures, which are not as accurate sodium/creatinine ratios because individuals may know amount in their food. Using data from a prospective cohort study, we investigated intake progression to precancerous lesions. Salt was estimated by urinary ratios, frequencies adding food, and total added table salt. We repeated analyses among groups with without...
Identification of disease variants via homozygosity mapping and investigation the effects genome-wide regions on traits biomedical importance have been widely applied recently. Nonetheless, existing methods algorithms to identify long tracts (TOH) are not able provide efficient rigorous for further downstream association investigation. We expanded current TOHs by defining "surrogate-TOH", a region covering cluster with specific characteristics. Our defined surrogate-TOH includes cTOH, viz...