A5025629807- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Central Venous Catheters and Hemodialysis
- Iron Metabolism and Disorders
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Hemoglobinopathies and Related Disorders
- Organ Donation and Transplantation
- Healthcare Policy and Management
- Renal Diseases and Glomerulopathies
- Pharmacological Effects and Toxicity Studies
- Innovations in Medical Education
- Muscle and Compartmental Disorders
- Parathyroid Disorders and Treatments
- Diversity and Career in Medicine
- Methemoglobinemia and Tumor Lysis Syndrome
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Blood transfusion and management
- Blood Pressure and Hypertension Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neonatal Health and Biochemistry
- Global Health Workforce Issues
- Parvovirus B19 Infection Studies
- Vascular Procedures and Complications
University of Pennsylvania
2015-2024
University of Pennsylvania Health System
2017-2024
Hospital of the University of Pennsylvania
2014-2023
St. Luke's Hospital
2021
Massachusetts General Hospital
2020
Pennsylvania Hospital
2011-2019
Philadelphia University
2002-2018
RELX Group (United States)
2016
World Economic Forum
2016
Palo Alto Institute
2016
Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease African Americans, but whether APOL1-associated glomerular has a distinct clinical phenotype is unknown. Here we determined APOL1 genotypes for 271 American cases, 168 European and 939 control subjects. In recessive model, conferred seventeenfold higher odds (95% CI 11 to 26) focal segmental glomerulosclerosis (FSGS) twenty-nine-fold 13 68) HIV-associated nephropathy (HIVAN). FSGS associated two...
There have been no recent analyses of the adequacy training in U.S. nephrology programs or importance specific aspects fellowship careers and practices nephrologists who recently completed training.An internet-based survey was sent to members American Society Nephrology 2004 2008. Respondents were asked rate their (little training, some but not enough feel competent, well trained competent) areas each area current practices.Among 133 adult trainees, most felt competent many patient care core...
Use of small changes in serum creatinine to diagnose AKI allows for earlier detection but may increase diagnostic false-positive rates because inherent laboratory and biologic variabilities creatinine.We examined measurement characteristics a prospective observational clinical reference cohort 2267 adult patients with by Kidney Disease Improving Global Outcomes criteria used these data create simulation model rates. We simulated up seven successive blood draws on an equal population...
The efficacy and safety of molidustat, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, have been evaluated in three 16-week, phase 2b studies patients with CKD anemia who are not on dialysis (DaIly orAL treatment increasing endOGenoUs Erythropoietin [DIALOGUE] 1 2) those (DIALOGUE 4).DIALOGUE was placebo-controlled, fixed-dose trial (25, 50, 75 mg once daily; 25 50 twice daily). DIALOGUE 2 4 were open-label, variable-dose trials, which switched from darbepoetin (DIAGLOGUE or epoetin...
<h3>Importance</h3> Many health systems are considering increasing price transparency at the time of order entry. However, evidence its impact on clinician ordering behavior is inconsistent and limited to single-site evaluations shorter duration. <h3>Objective</h3> To test effect displaying Medicare allowable fees for inpatient laboratory tests over 1 year. <h3>Design, Setting, Participants</h3> The Pragmatic Randomized Introduction Cost data through electronic record (PRICE) trial was a...
Hemoglobin variability is common among dialysis patients, and has been associated with increased mortality. The causal nature of this association difficult to ascertain because potential time-dependent confounding, for which traditional statistical methods do not control.
Some procedures (e.g., placement of temporary hemodialysis catheters and kidney biopsies) are required in nephrology fellowship training. Others tunneled catheters, ultrasonography, access interventions) not but performed at some centers. To assess the by nephrologists fellows U.S. adult training programs number for fellow competency, a survey was conducted all such programs.An on-line e-mailed to directors October November 2007.Responses were received from 93 136 programs. Nephrologists...
Background: Molidustat, a novel hypoxia-inducible factor-prolyl hydroxylase inhibitor, is being investigated for the treatment of anemia associated with chronic kidney disease (CKD). The efficacy and safety molidustat were recently evaluated in three 16-week phase 2b studies. Here, we report results two long-term extension studies molidustat. Methods: Both parallel-group, open-label, multicenter ≤36 months’ duration, patients due to CKD, included an erythropoiesis-stimulating agent as active...